Does coronavirus disease 2019 kill more elderly men than women due to different hormonal milieu
Preliminary data depicts a much greater prevalence and high case-fatality rate in advanced age males as compared to age-matched women with severe acute respiratory syndrome-coronavirus-2 infections with high morbidity, mortality, high referral, and admission to intensive care unit with severe sequel...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Journal of Mid-Life Health |
| Subjects: | |
| Online Access: | http://www.jmidlifehealth.org/article.asp?issn=0976-7800;year=2022;volume=13;issue=2;spage=96;epage=99;aulast=Tandon |
| _version_ | 1797995549335486464 |
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| author | Apurva Tandon Vishal R Tandon Sudhaa Sharma Annil Mahajan |
| author_facet | Apurva Tandon Vishal R Tandon Sudhaa Sharma Annil Mahajan |
| author_sort | Apurva Tandon |
| collection | DOAJ |
| description | Preliminary data depicts a much greater prevalence and high case-fatality rate in advanced age males as compared to age-matched women with severe acute respiratory syndrome-coronavirus-2 infections with high morbidity, mortality, high referral, and admission to intensive care unit with severe sequelae. However, the literature search revealed both for and against studies in this context. Thus, at present, in light of the mixed studies, it cannot be established whether low testosterone levels in aging hypogonadal males create a permissive environment for severe response to coronavirus disease 2019 (COVID-19) infection and can it increase the morbidity or mortality, or on the contrary if the virus inhibits androgen formation. Hence, it is highly warranted to establish the said hypothesis by conducting large statistically powered clinical studies in future. Further, it is highly indicated that impact of sex hormones and gender on the incidence and case fatality of the disease and hormones as a treatment according to sex and gender for COVID requires further scientific research by the research community before it is actually recommended to mitigate the COVID-19 disease course among elderly men and women at large. |
| first_indexed | 2024-04-11T10:03:25Z |
| format | Article |
| id | doaj.art-e1252b89fb7346f887b80d81c0d295d9 |
| institution | Directory Open Access Journal |
| issn | 0976-7800 0976-7819 |
| language | English |
| last_indexed | 2024-04-11T10:03:25Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Mid-Life Health |
| spelling | doaj.art-e1252b89fb7346f887b80d81c0d295d92022-12-22T04:30:19ZengWolters Kluwer Medknow PublicationsJournal of Mid-Life Health0976-78000976-78192022-01-01132969910.4103/jmh.jmh_37_22Does coronavirus disease 2019 kill more elderly men than women due to different hormonal milieuApurva TandonVishal R TandonSudhaa SharmaAnnil MahajanPreliminary data depicts a much greater prevalence and high case-fatality rate in advanced age males as compared to age-matched women with severe acute respiratory syndrome-coronavirus-2 infections with high morbidity, mortality, high referral, and admission to intensive care unit with severe sequelae. However, the literature search revealed both for and against studies in this context. Thus, at present, in light of the mixed studies, it cannot be established whether low testosterone levels in aging hypogonadal males create a permissive environment for severe response to coronavirus disease 2019 (COVID-19) infection and can it increase the morbidity or mortality, or on the contrary if the virus inhibits androgen formation. Hence, it is highly warranted to establish the said hypothesis by conducting large statistically powered clinical studies in future. Further, it is highly indicated that impact of sex hormones and gender on the incidence and case fatality of the disease and hormones as a treatment according to sex and gender for COVID requires further scientific research by the research community before it is actually recommended to mitigate the COVID-19 disease course among elderly men and women at large.http://www.jmidlifehealth.org/article.asp?issn=0976-7800;year=2022;volume=13;issue=2;spage=96;epage=99;aulast=Tandonandropausecoronavirus disease 2019menopausesevere acute respiratory syndrome-coronavirus-2testosterone |
| spellingShingle | Apurva Tandon Vishal R Tandon Sudhaa Sharma Annil Mahajan Does coronavirus disease 2019 kill more elderly men than women due to different hormonal milieu Journal of Mid-Life Health andropause coronavirus disease 2019 menopause severe acute respiratory syndrome-coronavirus-2 testosterone |
| title | Does coronavirus disease 2019 kill more elderly men than women due to different hormonal milieu |
| title_full | Does coronavirus disease 2019 kill more elderly men than women due to different hormonal milieu |
| title_fullStr | Does coronavirus disease 2019 kill more elderly men than women due to different hormonal milieu |
| title_full_unstemmed | Does coronavirus disease 2019 kill more elderly men than women due to different hormonal milieu |
| title_short | Does coronavirus disease 2019 kill more elderly men than women due to different hormonal milieu |
| title_sort | does coronavirus disease 2019 kill more elderly men than women due to different hormonal milieu |
| topic | andropause coronavirus disease 2019 menopause severe acute respiratory syndrome-coronavirus-2 testosterone |
| url | http://www.jmidlifehealth.org/article.asp?issn=0976-7800;year=2022;volume=13;issue=2;spage=96;epage=99;aulast=Tandon |
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