Different patterns of white matter microstructural alterations between psychotic and non-psychotic bipolar disorder.
This study aimed to investigate alterations in white matter (WM) microstructure in patients with psychotic and non-psychotic bipolar disorder (PBD and NPBD, respectively). We used 3T-magnetic resonance imaging to examine 29 PBD, 23 NPBD, and 65 healthy control (HC) subjects. Using tract-based spatia...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0265671 |
| _version_ | 1828202022515507200 |
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| author | Dong-Kyun Lee Hyeongrae Lee Vin Ryu Sung-Wan Kim Seunghyong Ryu |
| author_facet | Dong-Kyun Lee Hyeongrae Lee Vin Ryu Sung-Wan Kim Seunghyong Ryu |
| author_sort | Dong-Kyun Lee |
| collection | DOAJ |
| description | This study aimed to investigate alterations in white matter (WM) microstructure in patients with psychotic and non-psychotic bipolar disorder (PBD and NPBD, respectively). We used 3T-magnetic resonance imaging to examine 29 PBD, 23 NPBD, and 65 healthy control (HC) subjects. Using tract-based spatial statistics for diffusion tensor imaging data, we compared fractional anisotropy (FA) and mean diffusion (MD) pairwise among the PBD, NPBD, and HC groups. We found several WM areas of decreased FA or increased MD in the PBD and NPBD groups compared to HC. PBD showed widespread FA decreases in the corpus callosum as well as the bilateral internal capsule and fornix. However, NPBD showed local FA decreases in a part of the corpus callosum body as well as in limited regions within the left cerebral hemisphere, including the anterior and posterior corona radiata and the cingulum. In addition, both PBD and NPBD shared widespread MD increases across the posterior corona radiata, cingulum, and sagittal stratum. These findings suggest that widespread WM microstructural alterations might be a common neuroanatomical characteristic of bipolar disorder, regardless of being psychotic or non-psychotic. Particularly, PBD might involve extensive inter-and intra-hemispheric WM connectivity disruptions. |
| first_indexed | 2024-04-12T11:41:20Z |
| format | Article |
| id | doaj.art-e125ad30ad904eddaf70f58c6559fefe |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T11:41:20Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-e125ad30ad904eddaf70f58c6559fefe2022-12-22T03:34:39ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01173e026567110.1371/journal.pone.0265671Different patterns of white matter microstructural alterations between psychotic and non-psychotic bipolar disorder.Dong-Kyun LeeHyeongrae LeeVin RyuSung-Wan KimSeunghyong RyuThis study aimed to investigate alterations in white matter (WM) microstructure in patients with psychotic and non-psychotic bipolar disorder (PBD and NPBD, respectively). We used 3T-magnetic resonance imaging to examine 29 PBD, 23 NPBD, and 65 healthy control (HC) subjects. Using tract-based spatial statistics for diffusion tensor imaging data, we compared fractional anisotropy (FA) and mean diffusion (MD) pairwise among the PBD, NPBD, and HC groups. We found several WM areas of decreased FA or increased MD in the PBD and NPBD groups compared to HC. PBD showed widespread FA decreases in the corpus callosum as well as the bilateral internal capsule and fornix. However, NPBD showed local FA decreases in a part of the corpus callosum body as well as in limited regions within the left cerebral hemisphere, including the anterior and posterior corona radiata and the cingulum. In addition, both PBD and NPBD shared widespread MD increases across the posterior corona radiata, cingulum, and sagittal stratum. These findings suggest that widespread WM microstructural alterations might be a common neuroanatomical characteristic of bipolar disorder, regardless of being psychotic or non-psychotic. Particularly, PBD might involve extensive inter-and intra-hemispheric WM connectivity disruptions.https://doi.org/10.1371/journal.pone.0265671 |
| spellingShingle | Dong-Kyun Lee Hyeongrae Lee Vin Ryu Sung-Wan Kim Seunghyong Ryu Different patterns of white matter microstructural alterations between psychotic and non-psychotic bipolar disorder. PLoS ONE |
| title | Different patterns of white matter microstructural alterations between psychotic and non-psychotic bipolar disorder. |
| title_full | Different patterns of white matter microstructural alterations between psychotic and non-psychotic bipolar disorder. |
| title_fullStr | Different patterns of white matter microstructural alterations between psychotic and non-psychotic bipolar disorder. |
| title_full_unstemmed | Different patterns of white matter microstructural alterations between psychotic and non-psychotic bipolar disorder. |
| title_short | Different patterns of white matter microstructural alterations between psychotic and non-psychotic bipolar disorder. |
| title_sort | different patterns of white matter microstructural alterations between psychotic and non psychotic bipolar disorder |
| url | https://doi.org/10.1371/journal.pone.0265671 |
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