Progression to microalbuminuria in patients with type 1 diabetes: a seven-year prospective study
<p>Abstract</p> <p>Background</p> <p>The presence of microalbuminuria can be associated with overt nephropathy and cardiovascular disease in patients with type 1 diabetes (T1D). We aimed to determine the incidence and evaluate the baseline predictors for the development...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2011-08-01
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| Series: | Diabetology & Metabolic Syndrome |
| Subjects: | |
| Online Access: | http://www.dmsjournal.com/content/3/1/21 |
| _version_ | 1818212464411541504 |
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| author | Cobas Roberta A Santos Bráulio da Silva Pedro CB Neves Ricardo Gomes Marilia B |
| author_facet | Cobas Roberta A Santos Bráulio da Silva Pedro CB Neves Ricardo Gomes Marilia B |
| author_sort | Cobas Roberta A |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The presence of microalbuminuria can be associated with overt nephropathy and cardiovascular disease in patients with type 1 diabetes (T1D). We aimed to determine the incidence and evaluate the baseline predictors for the development of microalbuminuria in patients with T1D.</p> <p>Methods</p> <p>This study is a longitudinal cohort study of 122 normoalbuminuric patients with T1D who were receiving routine clinical care at baseline. A detailed medical history was taken, and a physical examination was performed at baseline. All of the patients were regularly examined for diabetes-associated complications. An analysis of predictors was performed using the Cox regression.</p> <p>Results</p> <p>Over 6.81 (3.59-9.75) years of follow-up, 50 (41%) of the patients developed microalbuminuria. The incidence density was 6.79/100 people per year (95% CI 5.04-8.95), and the microalbuminuria developed after 5.9 (2.44-7.76) and 11 (5-15) years of follow-up and diabetes duration, respectively. After an individual Cox regression, the baseline variables associated with the development of microalbuminuria were age, age at diagnosis, duration of diabetes, systolic and diastolic blood pressure, fasting glycemia, body mass index (BMI), total cholesterol and triglycerides levels, cholesterol/HDL ratio and a family history of type 2 diabetes.After a multivariate Cox regression, the only independent factors associated with the development of microalbuminuria were BMI [HR 1.12 (1.03-1.21)] and cholesterol/HDL ratio [HR 1.32 (1.05-1.67)].</p> <p>Conclusions</p> <p>A higher BMI and cholesterol/HDL ratio increased the risk of developing microalbuminuria in young patients with T1D after a short follow-up. Both risk factors are modifiable and should be identified early and followed closely.</p> |
| first_indexed | 2024-12-12T05:48:49Z |
| format | Article |
| id | doaj.art-e125b8e87be04c62b85c7a07f46398bf |
| institution | Directory Open Access Journal |
| issn | 1758-5996 |
| language | English |
| last_indexed | 2024-12-12T05:48:49Z |
| publishDate | 2011-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Diabetology & Metabolic Syndrome |
| spelling | doaj.art-e125b8e87be04c62b85c7a07f46398bf2022-12-22T00:35:44ZengBMCDiabetology & Metabolic Syndrome1758-59962011-08-01312110.1186/1758-5996-3-21Progression to microalbuminuria in patients with type 1 diabetes: a seven-year prospective studyCobas Roberta ASantos Bráulioda Silva Pedro CBNeves RicardoGomes Marilia B<p>Abstract</p> <p>Background</p> <p>The presence of microalbuminuria can be associated with overt nephropathy and cardiovascular disease in patients with type 1 diabetes (T1D). We aimed to determine the incidence and evaluate the baseline predictors for the development of microalbuminuria in patients with T1D.</p> <p>Methods</p> <p>This study is a longitudinal cohort study of 122 normoalbuminuric patients with T1D who were receiving routine clinical care at baseline. A detailed medical history was taken, and a physical examination was performed at baseline. All of the patients were regularly examined for diabetes-associated complications. An analysis of predictors was performed using the Cox regression.</p> <p>Results</p> <p>Over 6.81 (3.59-9.75) years of follow-up, 50 (41%) of the patients developed microalbuminuria. The incidence density was 6.79/100 people per year (95% CI 5.04-8.95), and the microalbuminuria developed after 5.9 (2.44-7.76) and 11 (5-15) years of follow-up and diabetes duration, respectively. After an individual Cox regression, the baseline variables associated with the development of microalbuminuria were age, age at diagnosis, duration of diabetes, systolic and diastolic blood pressure, fasting glycemia, body mass index (BMI), total cholesterol and triglycerides levels, cholesterol/HDL ratio and a family history of type 2 diabetes.After a multivariate Cox regression, the only independent factors associated with the development of microalbuminuria were BMI [HR 1.12 (1.03-1.21)] and cholesterol/HDL ratio [HR 1.32 (1.05-1.67)].</p> <p>Conclusions</p> <p>A higher BMI and cholesterol/HDL ratio increased the risk of developing microalbuminuria in young patients with T1D after a short follow-up. Both risk factors are modifiable and should be identified early and followed closely.</p>http://www.dmsjournal.com/content/3/1/21Diabetic NephropathyMicroalbuminuriaIncidenceRisk FactorsType 1 Diabetes |
| spellingShingle | Cobas Roberta A Santos Bráulio da Silva Pedro CB Neves Ricardo Gomes Marilia B Progression to microalbuminuria in patients with type 1 diabetes: a seven-year prospective study Diabetology & Metabolic Syndrome Diabetic Nephropathy Microalbuminuria Incidence Risk Factors Type 1 Diabetes |
| title | Progression to microalbuminuria in patients with type 1 diabetes: a seven-year prospective study |
| title_full | Progression to microalbuminuria in patients with type 1 diabetes: a seven-year prospective study |
| title_fullStr | Progression to microalbuminuria in patients with type 1 diabetes: a seven-year prospective study |
| title_full_unstemmed | Progression to microalbuminuria in patients with type 1 diabetes: a seven-year prospective study |
| title_short | Progression to microalbuminuria in patients with type 1 diabetes: a seven-year prospective study |
| title_sort | progression to microalbuminuria in patients with type 1 diabetes a seven year prospective study |
| topic | Diabetic Nephropathy Microalbuminuria Incidence Risk Factors Type 1 Diabetes |
| url | http://www.dmsjournal.com/content/3/1/21 |
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