Molecular Toxicology of Substances Released from Resin–Based Dental Restorative Materials
Resin-based dental restorative materials are extensively used today in dentistry. However, significant concerns still remain regarding their biocompatibility. For this reason, significant scientific effort has been focused on the determination of the molecular toxicology of substances released by th...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2009-09-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1422-0067/10/9/3861/ |
| _version_ | 1811312268097355776 |
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| author | Athina Bakopoulou Triantafillos Papadopoulos Pavlos Garefis |
| author_facet | Athina Bakopoulou Triantafillos Papadopoulos Pavlos Garefis |
| author_sort | Athina Bakopoulou |
| collection | DOAJ |
| description | Resin-based dental restorative materials are extensively used today in dentistry. However, significant concerns still remain regarding their biocompatibility. For this reason, significant scientific effort has been focused on the determination of the molecular toxicology of substances released by these biomaterials, using several tools for risk assessment, including exposure assessment, hazard identification and dose-response analysis. These studies have shown that substances released by these materials can cause significant cytotoxic and genotoxic effects, leading to irreversible disturbance of basic cellular functions. The aim of this article is to review current knowledge related to dental composites’ molecular toxicology and to give implications for possible improvements concerning their biocompatibility. |
| first_indexed | 2024-04-13T10:33:11Z |
| format | Article |
| id | doaj.art-e125bd57c2b7464b9c55e85f42f7ba71 |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-13T10:33:11Z |
| publishDate | 2009-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-e125bd57c2b7464b9c55e85f42f7ba712022-12-22T02:50:07ZengMDPI AGInternational Journal of Molecular Sciences1422-00672009-09-011093861389910.3390/ijms10093861Molecular Toxicology of Substances Released from Resin–Based Dental Restorative MaterialsAthina BakopoulouTriantafillos PapadopoulosPavlos GarefisResin-based dental restorative materials are extensively used today in dentistry. However, significant concerns still remain regarding their biocompatibility. For this reason, significant scientific effort has been focused on the determination of the molecular toxicology of substances released by these biomaterials, using several tools for risk assessment, including exposure assessment, hazard identification and dose-response analysis. These studies have shown that substances released by these materials can cause significant cytotoxic and genotoxic effects, leading to irreversible disturbance of basic cellular functions. The aim of this article is to review current knowledge related to dental composites’ molecular toxicology and to give implications for possible improvements concerning their biocompatibility.http://www.mdpi.com/1422-0067/10/9/3861/dental composite resinsmolecular toxicologybiocompatibilitybiodegradationcytotoxicitygenotoxicity |
| spellingShingle | Athina Bakopoulou Triantafillos Papadopoulos Pavlos Garefis Molecular Toxicology of Substances Released from Resin–Based Dental Restorative Materials International Journal of Molecular Sciences dental composite resins molecular toxicology biocompatibility biodegradation cytotoxicity genotoxicity |
| title | Molecular Toxicology of Substances Released from Resin–Based Dental Restorative Materials |
| title_full | Molecular Toxicology of Substances Released from Resin–Based Dental Restorative Materials |
| title_fullStr | Molecular Toxicology of Substances Released from Resin–Based Dental Restorative Materials |
| title_full_unstemmed | Molecular Toxicology of Substances Released from Resin–Based Dental Restorative Materials |
| title_short | Molecular Toxicology of Substances Released from Resin–Based Dental Restorative Materials |
| title_sort | molecular toxicology of substances released from resin based dental restorative materials |
| topic | dental composite resins molecular toxicology biocompatibility biodegradation cytotoxicity genotoxicity |
| url | http://www.mdpi.com/1422-0067/10/9/3861/ |
| work_keys_str_mv | AT athinabakopoulou moleculartoxicologyofsubstancesreleasedfromresinbaseddentalrestorativematerials AT triantafillospapadopoulos moleculartoxicologyofsubstancesreleasedfromresinbaseddentalrestorativematerials AT pavlosgarefis moleculartoxicologyofsubstancesreleasedfromresinbaseddentalrestorativematerials |