COVID-19 Biomarkers Comparison: Children, Adults and Elders
<i>Background and Objectives:</i> this study aimed to research links between C-reactive protein (CRP), lactate dehydrogenase (LDH), creatinekinase (CK), 25-OH vitamin D (25-OHD), ferritin (FER), high-density lipoprotein cholesterol (HDL)cholesterol and clinical severity in patients from...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/59/5/877 |
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| author | Ionut Dragos Capraru Dan Dumitru Vulcanescu Iulia Cristina Bagiu Florin George Horhat Irina Maria Popescu Luminita Mirela Baditoiu Delia Muntean Monica Licker Matilda Radulescu Ion Cristian Mot Mircea Mihai Diaconu Catalin Marian |
| author_facet | Ionut Dragos Capraru Dan Dumitru Vulcanescu Iulia Cristina Bagiu Florin George Horhat Irina Maria Popescu Luminita Mirela Baditoiu Delia Muntean Monica Licker Matilda Radulescu Ion Cristian Mot Mircea Mihai Diaconu Catalin Marian |
| author_sort | Ionut Dragos Capraru |
| collection | DOAJ |
| description | <i>Background and Objectives:</i> this study aimed to research links between C-reactive protein (CRP), lactate dehydrogenase (LDH), creatinekinase (CK), 25-OH vitamin D (25-OHD), ferritin (FER), high-density lipoprotein cholesterol (HDL)cholesterol and clinical severity in patients from the western part of Romania, and compare their potential use as biomarkers for intensive care units (ICU) admission and death in children, adults and elders. <i>Materials and Methods:</i> this study is a retrospective cohort study, performed on patients positively diagnosed with COVID-19. Available CRP, LDH, CK 25-OH vitamin D, ferritin, HDL cholesterol and clinical severity were recorded. The following were assessed: median group differences, association, correlation and receiver operating characteristic. <i>Results:</i> 381 children, 614 adults and 381 elders were studied between 1 March 2021 and 1 March 2022. Most children and adults presented mild symptomatology (53.28%, 35.02%, respectively), while most elders presented severe symptomatology (30.04%). ICU admission was 3.67% for children, 13.19% for adults and 46.09% for elders, while mortality was 0.79% for children, 8.63% for adults and 25.1% for elders. With the exception of CK, all other biomarkers showed some significant associations with clinical severity, ICU admission and death. <i>Conclusions:</i> CRP, LDH, 25-OH vitamin D, ferritin and HDL are important biomarkers for COVID-19 positive patients, especially in the pediatric population, while CK was mostly within normal ranges. |
| first_indexed | 2024-03-11T03:31:45Z |
| format | Article |
| id | doaj.art-e1274e43bb9b43bf8ea755f396e35ae8 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-11T03:31:45Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-e1274e43bb9b43bf8ea755f396e35ae82023-11-18T02:21:34ZengMDPI AGMedicina1010-660X1648-91442023-05-0159587710.3390/medicina59050877COVID-19 Biomarkers Comparison: Children, Adults and EldersIonut Dragos Capraru0Dan Dumitru Vulcanescu1Iulia Cristina Bagiu2Florin George Horhat3Irina Maria Popescu4Luminita Mirela Baditoiu5Delia Muntean6Monica Licker7Matilda Radulescu8Ion Cristian Mot9Mircea Mihai Diaconu10Catalin Marian11Department of Epidemiology, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Sq. Nr.2, 300041 Timisoara, RomaniaDepartment of Microbiology, Multidisciplinary Research Center on Antimicrobial Resistance, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Sq. Nr.2, 300041 Timisoara, RomaniaDepartment of Microbiology, Multidisciplinary Research Center on Antimicrobial Resistance, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Sq. Nr.2, 300041 Timisoara, RomaniaDepartment of Microbiology, Multidisciplinary Research Center on Antimicrobial Resistance, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Sq. Nr.2, 300041 Timisoara, RomaniaDepartment of Epidemiology, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Sq. Nr.2, 300041 Timisoara, RomaniaDepartment of Epidemiology, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Sq. Nr.2, 300041 Timisoara, RomaniaDepartment of Microbiology, Multidisciplinary Research Center on Antimicrobial Resistance, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Sq. Nr.2, 300041 Timisoara, RomaniaDepartment of Microbiology, Multidisciplinary Research Center on Antimicrobial Resistance, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Sq. Nr.2, 300041 Timisoara, RomaniaDepartment of Microbiology, Multidisciplinary Research Center on Antimicrobial Resistance, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Sq. Nr.2, 300041 Timisoara, RomaniaENT Department, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timisoara, RomaniaDepartment of Obstetrics and Gynecology, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, RomaniaDepartment of Biochemistry, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Sq. Nr.2, 300041 Timisoara, Romania<i>Background and Objectives:</i> this study aimed to research links between C-reactive protein (CRP), lactate dehydrogenase (LDH), creatinekinase (CK), 25-OH vitamin D (25-OHD), ferritin (FER), high-density lipoprotein cholesterol (HDL)cholesterol and clinical severity in patients from the western part of Romania, and compare their potential use as biomarkers for intensive care units (ICU) admission and death in children, adults and elders. <i>Materials and Methods:</i> this study is a retrospective cohort study, performed on patients positively diagnosed with COVID-19. Available CRP, LDH, CK 25-OH vitamin D, ferritin, HDL cholesterol and clinical severity were recorded. The following were assessed: median group differences, association, correlation and receiver operating characteristic. <i>Results:</i> 381 children, 614 adults and 381 elders were studied between 1 March 2021 and 1 March 2022. Most children and adults presented mild symptomatology (53.28%, 35.02%, respectively), while most elders presented severe symptomatology (30.04%). ICU admission was 3.67% for children, 13.19% for adults and 46.09% for elders, while mortality was 0.79% for children, 8.63% for adults and 25.1% for elders. With the exception of CK, all other biomarkers showed some significant associations with clinical severity, ICU admission and death. <i>Conclusions:</i> CRP, LDH, 25-OH vitamin D, ferritin and HDL are important biomarkers for COVID-19 positive patients, especially in the pediatric population, while CK was mostly within normal ranges.https://www.mdpi.com/1648-9144/59/5/877COVID-19SARS-CoV-2biomarkerschildrenadultselders |
| spellingShingle | Ionut Dragos Capraru Dan Dumitru Vulcanescu Iulia Cristina Bagiu Florin George Horhat Irina Maria Popescu Luminita Mirela Baditoiu Delia Muntean Monica Licker Matilda Radulescu Ion Cristian Mot Mircea Mihai Diaconu Catalin Marian COVID-19 Biomarkers Comparison: Children, Adults and Elders Medicina COVID-19 SARS-CoV-2 biomarkers children adults elders |
| title | COVID-19 Biomarkers Comparison: Children, Adults and Elders |
| title_full | COVID-19 Biomarkers Comparison: Children, Adults and Elders |
| title_fullStr | COVID-19 Biomarkers Comparison: Children, Adults and Elders |
| title_full_unstemmed | COVID-19 Biomarkers Comparison: Children, Adults and Elders |
| title_short | COVID-19 Biomarkers Comparison: Children, Adults and Elders |
| title_sort | covid 19 biomarkers comparison children adults and elders |
| topic | COVID-19 SARS-CoV-2 biomarkers children adults elders |
| url | https://www.mdpi.com/1648-9144/59/5/877 |
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