Factors associated with increased levels of brain natriuretic peptide and cardiac troponin I during the peripartum period.
BACKGROUND:We aimed to investigate the values and the changes of brain natriuretic peptide (BNP) and cardiac troponin in pregnant women. METHODS AND RESULTS:We prospectively collected the data of 405 pregnant women who were treated at Japanese general hospital between 2012 and 2013. We analyzed thei...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2019-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0211982 |
| _version_ | 1819016563595935744 |
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| author | Yuki Kimura Takao Kato Hiromi Miyata Issei Sasaki Eri Minamino-Muta Yoshinori Nagasawa Shigeharu Numao Tadayoshi Nagano Toshihiro Higuchi Moriaki Inoko |
| author_facet | Yuki Kimura Takao Kato Hiromi Miyata Issei Sasaki Eri Minamino-Muta Yoshinori Nagasawa Shigeharu Numao Tadayoshi Nagano Toshihiro Higuchi Moriaki Inoko |
| author_sort | Yuki Kimura |
| collection | DOAJ |
| description | BACKGROUND:We aimed to investigate the values and the changes of brain natriuretic peptide (BNP) and cardiac troponin in pregnant women. METHODS AND RESULTS:We prospectively collected the data of 405 pregnant women who were treated at Japanese general hospital between 2012 and 2013. We analyzed their laboratory data and echocardiographic findings during the third trimester (28-30 weeks' gestation) and within 4 days of delivery. In addition, we evaluated the factors associated with elevation of BNP and cardiac troponin I (cTnI) levels. The pregnant women were 33.8 ± 5.0 years old and the prevalence of pregnancy induced hypertension (PIH) and placental abnormality was 4.2% and 2.5%, respectively. BNP levels increased after delivery (13.2 pg/mL vs. 23.5 pg/mL; P <0.001), correlated with increased left ventricular diastolic dimension (P = 0.035), left atrial dimension (P <0.001), and decreased hemoglobin (P <0.001). Moreover, cTnI levels increased to over 0.015 ng/mL after delivery in 4.0% of pregnant women. In multivariate analysis, PIH (OR: 18.71, P = 0.003), placental abnormality (OR: 26.78, P = 0.007), and decreased hemoglobin after delivery (OR: 2.59, P <0.001) were the factors associated with elevated cTnI. CONCLUSIONS:BNP levels increased in association with cardiac chamber enlargement and decreased hemoglobin after delivery. Additionally, the factors affecting elevated cTnI levels were related to labor and delivery. |
| first_indexed | 2024-12-21T02:49:37Z |
| format | Article |
| id | doaj.art-e127d4c56d1e4fd0bae8dc369fab3e9a |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T02:49:37Z |
| publishDate | 2019-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-e127d4c56d1e4fd0bae8dc369fab3e9a2022-12-21T19:18:28ZengPublic Library of Science (PLoS)PLoS ONE1932-62032019-01-01142e021198210.1371/journal.pone.0211982Factors associated with increased levels of brain natriuretic peptide and cardiac troponin I during the peripartum period.Yuki KimuraTakao KatoHiromi MiyataIssei SasakiEri Minamino-MutaYoshinori NagasawaShigeharu NumaoTadayoshi NaganoToshihiro HiguchiMoriaki InokoBACKGROUND:We aimed to investigate the values and the changes of brain natriuretic peptide (BNP) and cardiac troponin in pregnant women. METHODS AND RESULTS:We prospectively collected the data of 405 pregnant women who were treated at Japanese general hospital between 2012 and 2013. We analyzed their laboratory data and echocardiographic findings during the third trimester (28-30 weeks' gestation) and within 4 days of delivery. In addition, we evaluated the factors associated with elevation of BNP and cardiac troponin I (cTnI) levels. The pregnant women were 33.8 ± 5.0 years old and the prevalence of pregnancy induced hypertension (PIH) and placental abnormality was 4.2% and 2.5%, respectively. BNP levels increased after delivery (13.2 pg/mL vs. 23.5 pg/mL; P <0.001), correlated with increased left ventricular diastolic dimension (P = 0.035), left atrial dimension (P <0.001), and decreased hemoglobin (P <0.001). Moreover, cTnI levels increased to over 0.015 ng/mL after delivery in 4.0% of pregnant women. In multivariate analysis, PIH (OR: 18.71, P = 0.003), placental abnormality (OR: 26.78, P = 0.007), and decreased hemoglobin after delivery (OR: 2.59, P <0.001) were the factors associated with elevated cTnI. CONCLUSIONS:BNP levels increased in association with cardiac chamber enlargement and decreased hemoglobin after delivery. Additionally, the factors affecting elevated cTnI levels were related to labor and delivery.https://doi.org/10.1371/journal.pone.0211982 |
| spellingShingle | Yuki Kimura Takao Kato Hiromi Miyata Issei Sasaki Eri Minamino-Muta Yoshinori Nagasawa Shigeharu Numao Tadayoshi Nagano Toshihiro Higuchi Moriaki Inoko Factors associated with increased levels of brain natriuretic peptide and cardiac troponin I during the peripartum period. PLoS ONE |
| title | Factors associated with increased levels of brain natriuretic peptide and cardiac troponin I during the peripartum period. |
| title_full | Factors associated with increased levels of brain natriuretic peptide and cardiac troponin I during the peripartum period. |
| title_fullStr | Factors associated with increased levels of brain natriuretic peptide and cardiac troponin I during the peripartum period. |
| title_full_unstemmed | Factors associated with increased levels of brain natriuretic peptide and cardiac troponin I during the peripartum period. |
| title_short | Factors associated with increased levels of brain natriuretic peptide and cardiac troponin I during the peripartum period. |
| title_sort | factors associated with increased levels of brain natriuretic peptide and cardiac troponin i during the peripartum period |
| url | https://doi.org/10.1371/journal.pone.0211982 |
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