Opportunistic infections among individuals with HIV-1/AIDS in the highly active antiretroviral therapy era at a Quaternary Level Care Teaching Hospital
INTRODUCTION : In this study, clinical-laboratory and epidemiological characteristics are described for a group of 700 individuals with HIV (human immunodeficiency virus)/AIDS (acquired immunodeficiency syndrome) in the ART (antiretroviral therapy) era at a teaching hospital that provides a quaterna...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Medicina Tropical (SBMT)
2015-04-01
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| Series: | Revista da Sociedade Brasileira de Medicina Tropical |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822015000200149&lng=en&tlng=en |
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| author | Katia Jaira Galisteu Luciana Ventura Cardoso Adriana Antônia da Cruz Furini Arlindo Schiesari Júnior Claudia Bernardi Cesarino Célia Franco Andrea Regina de Souza Baptista Ricardo Luiz Dantas Machado |
| author_facet | Katia Jaira Galisteu Luciana Ventura Cardoso Adriana Antônia da Cruz Furini Arlindo Schiesari Júnior Claudia Bernardi Cesarino Célia Franco Andrea Regina de Souza Baptista Ricardo Luiz Dantas Machado |
| author_sort | Katia Jaira Galisteu |
| collection | DOAJ |
| description | INTRODUCTION : In this study, clinical-laboratory and epidemiological characteristics are described for a group of 700 individuals with HIV (human immunodeficiency virus)/AIDS (acquired immunodeficiency syndrome) in the ART (antiretroviral therapy) era at a teaching hospital that provides a quaternary level of care, with an emphasis on opportunistic infections (OIs), co-infections and immune profile. METHODS : A retrospective cross-sectional study of AIDS cases was conducted from 1998 to 2008 by reviewing medical records from the Base Hospital/FUNFARME (Fundação Faculdade Regional de Medicina), São José do Rio Preto, São Paulo, Brazil. RESULTS: The individuals were 14 to 75 years of age, and 458 were males. Heterosexuals accounted for 31.1% of all patients. Eighty-three percent were on ART, and 33.8% of those presented difficulties with treatment adherence. OIs were analyzed from medical records, and Pneumocystis jiroveci pneumonia was the most prevalent, regardless of the LTCD4+ (TCD4+ Lymphocytes) levels. Individuals whose viral loads were ≥10,000 showed a 90% greater chance of neurotoxoplasmosis. For P. jiroveci pneumonia, neurotoxoplasmosis, esophageal candidiasis, pulmonary tuberculosis and neurocryptococcosis, the chances of infection were higher among patients with LTCD4+ levels below 200 cells/mm3. HIV/hepatitis C virus (HCV) and HIV/hepatitis B virus (HBV) co-infections were significantly associated with death. CONCLUSIONS : OIs remain frequent in the ART era even in populations where the access to medical care is considered satisfactory. |
| first_indexed | 2024-12-12T19:47:33Z |
| format | Article |
| id | doaj.art-e1280ba7b6a44753809bf57753bc1ba6 |
| institution | Directory Open Access Journal |
| issn | 1678-9849 |
| language | English |
| last_indexed | 2024-12-12T19:47:33Z |
| publishDate | 2015-04-01 |
| publisher | Sociedade Brasileira de Medicina Tropical (SBMT) |
| record_format | Article |
| series | Revista da Sociedade Brasileira de Medicina Tropical |
| spelling | doaj.art-e1280ba7b6a44753809bf57753bc1ba62022-12-22T00:14:03ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-98492015-04-0148214915610.1590/0037-8682-0299-2014S0037-86822015000200149Opportunistic infections among individuals with HIV-1/AIDS in the highly active antiretroviral therapy era at a Quaternary Level Care Teaching HospitalKatia Jaira GalisteuLuciana Ventura CardosoAdriana Antônia da Cruz FuriniArlindo Schiesari JúniorClaudia Bernardi CesarinoCélia FrancoAndrea Regina de Souza BaptistaRicardo Luiz Dantas MachadoINTRODUCTION : In this study, clinical-laboratory and epidemiological characteristics are described for a group of 700 individuals with HIV (human immunodeficiency virus)/AIDS (acquired immunodeficiency syndrome) in the ART (antiretroviral therapy) era at a teaching hospital that provides a quaternary level of care, with an emphasis on opportunistic infections (OIs), co-infections and immune profile. METHODS : A retrospective cross-sectional study of AIDS cases was conducted from 1998 to 2008 by reviewing medical records from the Base Hospital/FUNFARME (Fundação Faculdade Regional de Medicina), São José do Rio Preto, São Paulo, Brazil. RESULTS: The individuals were 14 to 75 years of age, and 458 were males. Heterosexuals accounted for 31.1% of all patients. Eighty-three percent were on ART, and 33.8% of those presented difficulties with treatment adherence. OIs were analyzed from medical records, and Pneumocystis jiroveci pneumonia was the most prevalent, regardless of the LTCD4+ (TCD4+ Lymphocytes) levels. Individuals whose viral loads were ≥10,000 showed a 90% greater chance of neurotoxoplasmosis. For P. jiroveci pneumonia, neurotoxoplasmosis, esophageal candidiasis, pulmonary tuberculosis and neurocryptococcosis, the chances of infection were higher among patients with LTCD4+ levels below 200 cells/mm3. HIV/hepatitis C virus (HCV) and HIV/hepatitis B virus (HBV) co-infections were significantly associated with death. CONCLUSIONS : OIs remain frequent in the ART era even in populations where the access to medical care is considered satisfactory.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822015000200149&lng=en&tlng=enHBVHCVHIVOpportunistic infections |
| spellingShingle | Katia Jaira Galisteu Luciana Ventura Cardoso Adriana Antônia da Cruz Furini Arlindo Schiesari Júnior Claudia Bernardi Cesarino Célia Franco Andrea Regina de Souza Baptista Ricardo Luiz Dantas Machado Opportunistic infections among individuals with HIV-1/AIDS in the highly active antiretroviral therapy era at a Quaternary Level Care Teaching Hospital Revista da Sociedade Brasileira de Medicina Tropical HBV HCV HIV Opportunistic infections |
| title | Opportunistic infections among individuals with HIV-1/AIDS in the highly active antiretroviral therapy era at a Quaternary Level Care Teaching Hospital |
| title_full | Opportunistic infections among individuals with HIV-1/AIDS in the highly active antiretroviral therapy era at a Quaternary Level Care Teaching Hospital |
| title_fullStr | Opportunistic infections among individuals with HIV-1/AIDS in the highly active antiretroviral therapy era at a Quaternary Level Care Teaching Hospital |
| title_full_unstemmed | Opportunistic infections among individuals with HIV-1/AIDS in the highly active antiretroviral therapy era at a Quaternary Level Care Teaching Hospital |
| title_short | Opportunistic infections among individuals with HIV-1/AIDS in the highly active antiretroviral therapy era at a Quaternary Level Care Teaching Hospital |
| title_sort | opportunistic infections among individuals with hiv 1 aids in the highly active antiretroviral therapy era at a quaternary level care teaching hospital |
| topic | HBV HCV HIV Opportunistic infections |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822015000200149&lng=en&tlng=en |
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