Stiffness of HIV‐1 Mimicking Polymer Nanoparticles Modulates Ganglioside‐Mediated Cellular Uptake and Trafficking

Stiffness of HIV‐1 Mimicking Polymer Nanoparticles Modulates Ganglioside‐Mediated Cellular Uptake and Trafficking

Abstract The monosialodihexosylganglioside, GM3, and its binding to CD169 (Siglec‐1) have been indicated as key factors in the glycoprotein‐independent sequestration of the human immunodeficiency virus‐1 (HIV‐1) in virus‐containing compartments (VCCs) in myeloid cells. Here, lipid‐wrapped polymer na...

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Bibliographic Details
Main Authors: Behnaz Eshaghi, Nourin Alsharif, Xingda An, Hisashi Akiyama, Keith A. Brown, Suryaram Gummuluru, Björn M. Reinhard
Format: Article
Language:English
Published: Wiley 2020-09-01
Series:Advanced Science
Subjects:
biomimetic nanoparticles
endocytosis
lectins
lipid‐wrapped nanoparticles
siglec‐1
Online Access:https://doi.org/10.1002/advs.202000649

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