Impact of early antibiotic exposure on the risk of colonization with potential pathogens in very preterm infants: a retrospective cohort analysis
Abstract Background Sepsis is one of the most important complications in preterm infants. For this reason, most preterm infants receive antibiotics during their first postnatal week. Since 2013, a weekly colonization screening has been installed in German neonatal intensive care units (NICUs), inclu...
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| Format: | Article |
| Language: | English |
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BMC
2022-05-01
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| Series: | Antimicrobial Resistance and Infection Control |
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| Online Access: | https://doi.org/10.1186/s13756-022-01110-1 |
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| author | Caren Bubser Jan Liese Lina Maria Serna-Higuita Andreas Müller Matthias Vochem Jörg Arand Ulrich Karck Maximilian Gross Christian F. Poets Christoph Härtel Michael Zemlin Christian Gille Natascha Köstlin-Gille |
| author_facet | Caren Bubser Jan Liese Lina Maria Serna-Higuita Andreas Müller Matthias Vochem Jörg Arand Ulrich Karck Maximilian Gross Christian F. Poets Christoph Härtel Michael Zemlin Christian Gille Natascha Köstlin-Gille |
| author_sort | Caren Bubser |
| collection | DOAJ |
| description | Abstract Background Sepsis is one of the most important complications in preterm infants. For this reason, most preterm infants receive antibiotics during their first postnatal week. Since 2013, a weekly colonization screening has been installed in German neonatal intensive care units (NICUs), including multi-drug resistant organisms (MDRO) and pathogens with increased epidemic potential. We here investigated the impact of early antibiotic exposure on the colonization with these pathogens. Methods Data from 1407 preterm infants with gestational age < 32 + 0 weeks and born in three NICUs in Germany between January 2014 and December 2019 were analysed. Results Antibiotics were administered to 911/1407 (64.7%) participating infants during their first postnatal week. Screening-targeted pathogens were detected in 547/1407 (38.9%). Early antibiotic exposure did not increase the risk of colonization with screening-targeted pathogens. The only independent risk factor for colonisation with potential pathogens was the admitting hospital. Interestingly, longer antibiotic therapy (> 7 days) decreased the risk for acquiring pathogens with increased epidemic potential. Conclusion Early antibiotic exposure did not impact the risk for colonization with MDRO or highly epidemic pathogens in preterm infants. Further studies are needed to identify risk factors for the acquisition of MDRO and highly epidemic pathogens and potential associations with long-term outcome. |
| first_indexed | 2024-04-13T18:52:12Z |
| format | Article |
| id | doaj.art-e129359fb5d14a57807b16e35b2efa49 |
| institution | Directory Open Access Journal |
| issn | 2047-2994 |
| language | English |
| last_indexed | 2024-04-13T18:52:12Z |
| publishDate | 2022-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Antimicrobial Resistance and Infection Control |
| spelling | doaj.art-e129359fb5d14a57807b16e35b2efa492022-12-22T02:34:23ZengBMCAntimicrobial Resistance and Infection Control2047-29942022-05-011111910.1186/s13756-022-01110-1Impact of early antibiotic exposure on the risk of colonization with potential pathogens in very preterm infants: a retrospective cohort analysisCaren Bubser0Jan Liese1Lina Maria Serna-Higuita2Andreas Müller3Matthias Vochem4Jörg Arand5Ulrich Karck6Maximilian Gross7Christian F. Poets8Christoph Härtel9Michael Zemlin10Christian Gille11Natascha Köstlin-Gille12Department of Neonatology, Tübingen University Children’s HospitalInstitute of Medical Microbiology and Hygiene, Tübingen University HospitalDepartment of Clinical Epidemiology and Applied Biostatistics, Eberhard Karls UniversityDepartment of Paediatrics, University of BonnDepartment of Neonatology, Klinikum Stuttgart Olgahospital/FrauenklinikDepartment of Neonatology, Tübingen University Children’s HospitalClinic of Obstetrics and Gynecology, Klinikum Stuttgart Olgahospital/FrauenklinikDepartment of Neonatology, Tübingen University Children’s HospitalDepartment of Neonatology, Tübingen University Children’s HospitalDepartment of Paediatrics, University of WürzburgDepartment of Paediatrics, Saar University HomburgDepartment of Neonatology, Heidelberg University Children’s HospitalDepartment of Neonatology, Tübingen University Children’s HospitalAbstract Background Sepsis is one of the most important complications in preterm infants. For this reason, most preterm infants receive antibiotics during their first postnatal week. Since 2013, a weekly colonization screening has been installed in German neonatal intensive care units (NICUs), including multi-drug resistant organisms (MDRO) and pathogens with increased epidemic potential. We here investigated the impact of early antibiotic exposure on the colonization with these pathogens. Methods Data from 1407 preterm infants with gestational age < 32 + 0 weeks and born in three NICUs in Germany between January 2014 and December 2019 were analysed. Results Antibiotics were administered to 911/1407 (64.7%) participating infants during their first postnatal week. Screening-targeted pathogens were detected in 547/1407 (38.9%). Early antibiotic exposure did not increase the risk of colonization with screening-targeted pathogens. The only independent risk factor for colonisation with potential pathogens was the admitting hospital. Interestingly, longer antibiotic therapy (> 7 days) decreased the risk for acquiring pathogens with increased epidemic potential. Conclusion Early antibiotic exposure did not impact the risk for colonization with MDRO or highly epidemic pathogens in preterm infants. Further studies are needed to identify risk factors for the acquisition of MDRO and highly epidemic pathogens and potential associations with long-term outcome.https://doi.org/10.1186/s13756-022-01110-1MDROEarly antibiotic exposurePreterm infantsDysbiosis |
| spellingShingle | Caren Bubser Jan Liese Lina Maria Serna-Higuita Andreas Müller Matthias Vochem Jörg Arand Ulrich Karck Maximilian Gross Christian F. Poets Christoph Härtel Michael Zemlin Christian Gille Natascha Köstlin-Gille Impact of early antibiotic exposure on the risk of colonization with potential pathogens in very preterm infants: a retrospective cohort analysis Antimicrobial Resistance and Infection Control MDRO Early antibiotic exposure Preterm infants Dysbiosis |
| title | Impact of early antibiotic exposure on the risk of colonization with potential pathogens in very preterm infants: a retrospective cohort analysis |
| title_full | Impact of early antibiotic exposure on the risk of colonization with potential pathogens in very preterm infants: a retrospective cohort analysis |
| title_fullStr | Impact of early antibiotic exposure on the risk of colonization with potential pathogens in very preterm infants: a retrospective cohort analysis |
| title_full_unstemmed | Impact of early antibiotic exposure on the risk of colonization with potential pathogens in very preterm infants: a retrospective cohort analysis |
| title_short | Impact of early antibiotic exposure on the risk of colonization with potential pathogens in very preterm infants: a retrospective cohort analysis |
| title_sort | impact of early antibiotic exposure on the risk of colonization with potential pathogens in very preterm infants a retrospective cohort analysis |
| topic | MDRO Early antibiotic exposure Preterm infants Dysbiosis |
| url | https://doi.org/10.1186/s13756-022-01110-1 |
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