Neurobehavioral Impairment in Pediatric Brain Tumor Survivors: A Meta-Analysis
Purpose: The neurocognitive outcomes of pediatric brain tumor survivors have been extensively studied but the risk and predictors for neurobehavioral impairment are less clearly defined. We systematically analyzed the rates of emotional, psychosocial, and attention problems in pediatric brain tumor...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/13/3269 |
| _version_ | 1797480643499655168 |
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| author | Yuliang Wang Anthony Pak Yin Liu Tatia Mei-Chun Lee Wilfred Hing Sang Wong Daniel Yee Tak Fong Lok Kan Leung Matthew Ming Kong Shing Dennis Tak-Loi Ku Godfrey Chi-Fung Chan Winnie Wan-Yee Tso |
| author_facet | Yuliang Wang Anthony Pak Yin Liu Tatia Mei-Chun Lee Wilfred Hing Sang Wong Daniel Yee Tak Fong Lok Kan Leung Matthew Ming Kong Shing Dennis Tak-Loi Ku Godfrey Chi-Fung Chan Winnie Wan-Yee Tso |
| author_sort | Yuliang Wang |
| collection | DOAJ |
| description | Purpose: The neurocognitive outcomes of pediatric brain tumor survivors have been extensively studied but the risk and predictors for neurobehavioral impairment are less clearly defined. We systematically analyzed the rates of emotional, psychosocial, and attention problems in pediatric brain tumor survivors. Methods: PubMed, Web of Science, Embase, Scopus, and Cochrane were searched for articles published between January 2012 to April 2022. Eligible studies reported neurobehavioral outcomes for PBTS aged 2 to <23 years with a brain tumor diagnosis before 18 years of age. A random-effect meta-analysis was performed in R. Results: The search yielded 1187 unique publications, of which 50 were included in the quantitative analysis. The estimated risk of having emotional, psychosocial, and attention problems were 15% (95%CI 10–20%), 12% (95%CI 9–16%), and 12% (95%CI 9–16%), respectively. PBTS were more likely to have emotional difficulties (Hedge’s g = 0.43 [95%CI 0.34–0.52]), psychosocial problems (Hedge’s g = 0.46 [95%CI 0.33–0.58]), and attention problems (Hedge’s g = 0.48 [95%CI 0.34–0.63]) compared to normal/healthy control subjects. There was no significant difference in the rates of neurobehavioral impairment between children with and without history of cranial radiotherapy. Conclusions: PBTS are at elevated risk of neurobehavioral impairment. Neurobehavioral monitoring should be considered as the standard of care for PBTS. |
| first_indexed | 2024-03-09T22:03:01Z |
| format | Article |
| id | doaj.art-e1296516708c49a98e2aeefc4e6407cb |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T22:03:01Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-e1296516708c49a98e2aeefc4e6407cb2023-11-23T19:47:11ZengMDPI AGCancers2072-66942022-07-011413326910.3390/cancers14133269Neurobehavioral Impairment in Pediatric Brain Tumor Survivors: A Meta-AnalysisYuliang Wang0Anthony Pak Yin Liu1Tatia Mei-Chun Lee2Wilfred Hing Sang Wong3Daniel Yee Tak Fong4Lok Kan Leung5Matthew Ming Kong Shing6Dennis Tak-Loi Ku7Godfrey Chi-Fung Chan8Winnie Wan-Yee Tso9Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, ChinaDepartment of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, ChinaState Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong, ChinaDepartment of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, ChinaSchool of Nursing, The University of Hong Kong, Hong Kong, ChinaDepartment of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, ChinaDepartment of Paediatrics and Adolescent Medicine, Hong Kong Children’s Hospital, Hong Kong, ChinaState Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong, ChinaDepartment of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, ChinaDepartment of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, ChinaPurpose: The neurocognitive outcomes of pediatric brain tumor survivors have been extensively studied but the risk and predictors for neurobehavioral impairment are less clearly defined. We systematically analyzed the rates of emotional, psychosocial, and attention problems in pediatric brain tumor survivors. Methods: PubMed, Web of Science, Embase, Scopus, and Cochrane were searched for articles published between January 2012 to April 2022. Eligible studies reported neurobehavioral outcomes for PBTS aged 2 to <23 years with a brain tumor diagnosis before 18 years of age. A random-effect meta-analysis was performed in R. Results: The search yielded 1187 unique publications, of which 50 were included in the quantitative analysis. The estimated risk of having emotional, psychosocial, and attention problems were 15% (95%CI 10–20%), 12% (95%CI 9–16%), and 12% (95%CI 9–16%), respectively. PBTS were more likely to have emotional difficulties (Hedge’s g = 0.43 [95%CI 0.34–0.52]), psychosocial problems (Hedge’s g = 0.46 [95%CI 0.33–0.58]), and attention problems (Hedge’s g = 0.48 [95%CI 0.34–0.63]) compared to normal/healthy control subjects. There was no significant difference in the rates of neurobehavioral impairment between children with and without history of cranial radiotherapy. Conclusions: PBTS are at elevated risk of neurobehavioral impairment. Neurobehavioral monitoring should be considered as the standard of care for PBTS.https://www.mdpi.com/2072-6694/14/13/3269pediatric brain tumor survivorsneurobehavioral impairmentmeta-analysis |
| spellingShingle | Yuliang Wang Anthony Pak Yin Liu Tatia Mei-Chun Lee Wilfred Hing Sang Wong Daniel Yee Tak Fong Lok Kan Leung Matthew Ming Kong Shing Dennis Tak-Loi Ku Godfrey Chi-Fung Chan Winnie Wan-Yee Tso Neurobehavioral Impairment in Pediatric Brain Tumor Survivors: A Meta-Analysis Cancers pediatric brain tumor survivors neurobehavioral impairment meta-analysis |
| title | Neurobehavioral Impairment in Pediatric Brain Tumor Survivors: A Meta-Analysis |
| title_full | Neurobehavioral Impairment in Pediatric Brain Tumor Survivors: A Meta-Analysis |
| title_fullStr | Neurobehavioral Impairment in Pediatric Brain Tumor Survivors: A Meta-Analysis |
| title_full_unstemmed | Neurobehavioral Impairment in Pediatric Brain Tumor Survivors: A Meta-Analysis |
| title_short | Neurobehavioral Impairment in Pediatric Brain Tumor Survivors: A Meta-Analysis |
| title_sort | neurobehavioral impairment in pediatric brain tumor survivors a meta analysis |
| topic | pediatric brain tumor survivors neurobehavioral impairment meta-analysis |
| url | https://www.mdpi.com/2072-6694/14/13/3269 |
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