SMAD4 Expression in Renal Cell Carcinomas Correlates With a Stem-Cell Phenotype and Poor Clinical Outcomes

SMAD4 Expression in Renal Cell Carcinomas Correlates With a Stem-Cell Phenotype and Poor Clinical Outcomes

Renal cell carcinoma (RCC) is the most lethal neoplasm of common urologic cancers with poor prognoses. SMAD4 has a principal role in TGF-β (Transformis growth factorβ)-induced epithelial to mesenchymal transition (EMT) as a key factor in gaining cancer stem cell (CSC) features and tumor aggressivene...

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Bibliographic Details
Main Authors: Arezoo Rasti, Zahra Madjd, Leili Saeednejad Zanjani, Sadegh Babashah, Maryam Abolhasani, Mojgan Asgari, Mitra Mehrazma
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Oncology
Subjects:
renal cancer
cancer stem cells
targeting
TGFβ signaling pathway
epithelial to mesenchymal transition
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.581172/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.581172/full

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