SMAD4 Expression in Renal Cell Carcinomas Correlates With a Stem-Cell Phenotype and Poor Clinical Outcomes

SMAD4 Expression in Renal Cell Carcinomas Correlates With a Stem-Cell Phenotype and Poor Clinical Outcomes

Renal cell carcinoma (RCC) is the most lethal neoplasm of common urologic cancers with poor prognoses. SMAD4 has a principal role in TGF-β (Transformis growth factorβ)-induced epithelial to mesenchymal transition (EMT) as a key factor in gaining cancer stem cell (CSC) features and tumor aggressivene...

Full description

Bibliographic Details
Main Authors:	Arezoo Rasti, Zahra Madjd, Leili Saeednejad Zanjani, Sadegh Babashah, Maryam Abolhasani, Mojgan Asgari, Mitra Mehrazma
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-05-01
Series:	Frontiers in Oncology
Subjects:	renal cancer cancer stem cells targeting TGFβ signaling pathway epithelial to mesenchymal transition
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2021.581172/full

Similar Items

Significant co-expression of putative cancer stem cell markers, EpCAM and CD166, correlates with tumor stage and invasive behavior in colorectal cancer
by: Elham Kalantari, et al.
Published: (2022-01-01)

Circulating cancer stem cell markers in breast carcinomas: a systematic review protocol
by: Maryam Mansoori, et al.
Published: (2017-12-01)

Exosomal microRNAs as potential circulating biomarkers in gastrointestinal tract cancers: a systematic review protocol
by: Elmira Gheytanchi, et al.
Published: (2017-11-01)

The platinum coordination complex inhibits cell invasion-migration and epithelial-to-mesenchymal transition by altering the TGF-β-SMAD pathway in colorectal cancer
by: Maha-Hamadien Abdulla, et al.
Published: (2023-11-01)

Publisher Correction: Co-expression of cancer-testis antigens of MAGE-A6 and MAGE-A11 is associated with tumor aggressiveness in patients with bladder cancer
by: Monireh Mohsenzadegan, et al.
Published: (2022-02-01)

<i>Cinnamomum bejolghota</i> Extract Inhibits Colorectal Cancer Cell Metastasis and TGF-β1-Induced Epithelial-Mesenchymal Transition via Smad and Non-Smad Signaling Pathway
by: Athicha Kittiwattanokhun, et al.
Published: (2022-05-01)

Tumor matrix stiffness provides fertile soil for cancer stem cells
by: Sadegh Safaei, et al.
Published: (2023-07-01)

CTHRC1 overexpression predicts poor survival and enhances epithelial‐mesenchymal transition in colorectal cancer
by: Shujuan Ni, et al.
Published: (2018-11-01)

Cytoplasmic SALL4-A isoform expression as a diagnostic marker of less aggressive tumor behavior in gastric cancer
by: Saeed Rahmani, et al.
Published: (2025-02-01)

Nuclear Expression of Dynamin 2 Is Associated With Tumor Aggressiveness in Bladder Cancer Patients: A Bioinformatics and Experimental Approach
by: Mahdieh Razmi, et al.
Published: (2024-12-01)

SNORA38B promotes proliferation, migration, invasion and epithelial-mesenchymal transition of gallbladder cancer cells <em>via</em> activating TGF-β/Smad2/3 signaling
by: Yiyu Qin, et al.
Published: (2023-12-01)

SOX4 contributes to TGF-β-induced epithelial–mesenchymal transition and stem cell characteristics of gastric cancer cells
by: Xudong Peng, et al.
Published: (2018-03-01)

Exosomes derived from mesenchymal stem cells reverse EMT via TGF-β1/Smad pathway and promote repair of damaged endometrium
by: Yuan Yao, et al.
Published: (2019-07-01)

Isoliensinine suppressed gastric cancer cell proliferation and migration by targeting TGFBR1 to regulate TGF-β-smad signaling pathways
by: Jinda Hu, et al.
Published: (2024-09-01)

Botox-A induced apoptosis and suppressed cell proliferation in fibroblasts pre-treated with breast cancer exosomes
by: Hossein Sayaf, et al.
Published: (2025-02-01)

Regulatory T Cells Induce Metastasis by Activating Tgf-Β and Enhancing the Epithelial–Mesenchymal Transition
by: Eonju Oh, et al.
Published: (2019-11-01)

Smad4 regulates TGF-β1-mediated hedgehog activation to promote epithelial-to-mesenchymal transition in pancreatic cancer cells by suppressing Gli1 activity
by: Hangcheng Guo, et al.
Published: (2024-12-01)

CircRNAs: Pivotal modulators of TGF-β signalling in cancer pathogenesis
by: Asif Ahmad Bhat, et al.
Published: (2024-06-01)

Overexpression of mircoRNA-137 inhibits cervical cancer cell invasion, migration and epithelial–mesenchymal transition by suppressing the TGF-β/smad pathway via binding to GREM1
by: Hui Miao, et al.
Published: (2019-05-01)

High expression of Talin-1 is associated with tumor progression and recurrence in melanoma skin cancer patients
by: Yasaman Rezaie, et al.
Published: (2023-04-01)

Characterization of Epithelial–Mesenchymal and Neuroendocrine Differentiation States in Pancreatic and Small Cell Ovarian Tumor Cells and Their Modulation by TGF-β1 and BMP-7
by: Hendrik Ungefroren, et al.
Published: (2024-12-01)

Fruquintinib inhibits the migration and invasion of colorectal cancer cells by modulating epithelial-mesenchymal transition via TGF-β/Smad signaling pathway
by: Qinqin Song, et al.
Published: (2025-03-01)

Mechanism of FKBP10 promoting proliferation and migration of gastric cancer cells
by: GUO Dan, et al.
Published: (2023-06-01)

Epithelial Cell Adhesion Molecule: An Anchor to Isolate Clinically Relevant Circulating Tumor Cells
by: Zahra Eslami-S, et al.
Published: (2020-08-01)

Paeonol Inhibits Pancreatic Cancer Cell Migration and Invasion Through the Inhibition of TGF-β1/Smad Signaling and Epithelial-Mesenchymal-Transition
by: Cheng CS, et al.
Published: (2020-01-01)

On-Target Anti-TGF-β Therapies Are Not Succeeding in Clinical Cancer Treatments: What Are Remaining Challenges?
by: Adilson Fonseca Teixeira, et al.
Published: (2020-07-01)

Acacetin inhibits invasion, migration and TGF-β1-induced EMT of gastric cancer cells through the PI3K/Akt/Snail pathway
by: Guangtao Zhang, et al.
Published: (2022-01-01)

miR-21 and miR-155 in the regulation of TGF-β1/SMAD signaling pathway of the line breast cancer cells with different metastatic potential
by: Z. N. Nikiphorova, et al.
Published: (2015-09-01)

The role of cytidine 5′‐triphosphate synthetase 1 in metabolic rewiring during epithelial‐to‐mesenchymal transition in non‐small‐cell lung cancer
by: Fumie Nakasuka, et al.
Published: (2024-09-01)

UHRF1 promotes epithelial-mesenchymal transition mediating renal fibrosis by activating the TGF-β/SMAD signaling pathway
by: Lijie Yang, et al.
Published: (2025-01-01)

TGF-β uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition
by: Anassuya Ramachandran, et al.
Published: (2018-01-01)

Increased nuclear expression of DNA damage inducible transcript 4 can serve as a potential prognostic biomarker in patients with gliomas: a study based on data mining and experimental tools
by: Alireza Sadeghipour, et al.
Published: (2025-02-01)

Novel nanoliposomal encapsulated omega-3 fatty acids and their applications in food
by: Babak Rasti, et al.
Published: (2017)

Different Regulation of Glut1 Expression and Glucose Uptake during the Induction and Chronic Stages of TGFβ1-Induced EMT in Breast Cancer Cells
by: Azadeh Nilchian, et al.
Published: (2020-12-01)

Association of the TGFβ gene family with microenvironmental features of gastric cancer and prediction of response to immunotherapy
by: Bangling Han, et al.
Published: (2022-09-01)

Expression of vimentin, E-cadherin and TGF-β as markers of epithelial-mesenchymal transformation and criteria for the prognosis of the diseaseby epithelium in benign pathology and prostate gland cancer
by: P. V. Tkachenko, et al.
Published: (2017-07-01)

HOXD9 promote epithelial‐mesenchymal transition and metastasis in colorectal carcinoma
by: Mengwei Liu, et al.
Published: (2020-06-01)

Expression of vimentin, E-cadherin and TGF-β as markers of epithelial-mesenchymal transformation and criteria for the prognosis of the diseaseby epithelium in benign pathology and prostate gland cancer
by: P. V. Tkachenko, et al.
Published: (2017-07-01)

Glycyrrhizin suppresses epithelial-mesenchymal transition by inhibiting high-mobility group box1 via the TGF-β1/Smad2/3 pathway in lung epithelial cells
by: Yanni Gui, et al.
Published: (2020-02-01)

RSK3 switches cell fate: from stress-induced senescence to malignant progression
by: Anda Huna, et al.
Published: (2023-11-01)