Relationship of Peripapillary Retinal Perfusion with Peripapillary Retinal Nerve Fiber Layer Thickness in Diabetes Mellitus Patients without Diabetic Retinopathy
Introduction: Impaired blood flow is an early sign of retinal dysfunction in diabetes. Impaired blood flow of the radial peripapillary capillaries can affect the Retinal Nerve Fiber Layer (RNFL) or ganglion cell function. Methods: This was an analytic cross-sectional study in February-April 20...
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| Format: | Article |
| Language: | English |
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International Journal of Retina
2021-09-01
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| Series: | IJRETINA (International Journal of Retina) |
| Online Access: | https://www.ijretina.com/index.php/ijretina/article/view/161 |
| _version_ | 1811174358743252992 |
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| author | Sindi Dwijayanti Irawati Irfani Susanti Natalya Sirait Elsa Gustianty Erwin Iskandar R. Angga Kartiwa |
| author_facet | Sindi Dwijayanti Irawati Irfani Susanti Natalya Sirait Elsa Gustianty Erwin Iskandar R. Angga Kartiwa |
| author_sort | Sindi Dwijayanti |
| collection | DOAJ |
| description |
Introduction: Impaired blood flow is an early sign of retinal dysfunction in diabetes. Impaired blood flow of the radial peripapillary capillaries can affect the Retinal Nerve Fiber Layer (RNFL) or ganglion cell function.
Methods: This was an analytic cross-sectional study in February-April 2019 at Bandung. The subjects of this study were 41 people (79 eyes) divided into two groups, group A (healthy subjects) 19 people (37 eyes) and group B (DM type 2 without diabetic retinopathy) 22 people (42 eyes). Peripapillary retinal perfusion was assesed using OCT Angiography and RNFL thickness was assesed using OCT. Pearson or Spearman correlation statistics test was used to analyze the result. P value ≤0.05 was consiedered significant.
Results: There was a decrease in peripapillary retinal perfusion density in the inferior quadrant (P = 0.003) and flux index throughout the peripapillary retinal quadrant (P = 0.0001) but an increase in RNFL thickness in the peripapillary temporal quadrant (P = 0.012) compared to control grup. Positive correlation was found between peripapillary retinal perfusion density and RNFL thickness globally (r = 0.480, P = 0.001), superior quadrant (r = 0.436, P = 0.004), and inferior quadrant (r = 0.608, P = 0.000). A positive correlation was also found between the peripapillary flux and RNFL thickness globally (r = 0.517, P = 0.000), superior quadrant (r = 0.630, P = 0.000), and inferior quadrant (r = 0.519, P = 0.000).
Conclusions: There was a relationship between peripapillary retinal perfusion and RNFL thickness in DM patients without diabetic retinopathy.
Keywords: Peripapillary perfusion, RNFL thickness, Diabetes.
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| first_indexed | 2024-04-10T19:18:57Z |
| format | Article |
| id | doaj.art-e12c1d0abcc8418391da9fabb5bbc66e |
| institution | Directory Open Access Journal |
| issn | 2614-8684 2614-8536 |
| language | English |
| last_indexed | 2024-04-10T19:18:57Z |
| publishDate | 2021-09-01 |
| publisher | International Journal of Retina |
| record_format | Article |
| series | IJRETINA (International Journal of Retina) |
| spelling | doaj.art-e12c1d0abcc8418391da9fabb5bbc66e2023-01-30T09:59:44ZengInternational Journal of RetinaIJRETINA (International Journal of Retina)2614-86842614-85362021-09-014210.35479/ijretina.2021.vol004.iss002.161 Relationship of Peripapillary Retinal Perfusion with Peripapillary Retinal Nerve Fiber Layer Thickness in Diabetes Mellitus Patients without Diabetic RetinopathySindi Dwijayanti0Irawati Irfani1Susanti Natalya Sirait2Elsa Gustianty3Erwin Iskandar4R. Angga Kartiwa5Cicendo National Eye Hospital, Bandung, IndonesiaPediatric Ophthalmology and Strabismus Division, Cicendo National Eye Hospital, Bandung, IndonesiaRefraction, contact lens, and low vision Division, Cicendo National Eye Hospital, Bandung, IndonesiaGlaucoma Division, Cicendo National Eye Hospital, Bandung, IndonesiaVitreoretina Division, Cicendo National Eye Hospital, Bandung, IndonesiaReconstruction, Oculoplasty, and Oncology Division, Cicendo National Eye Hospital, Bandung, Indonesia Introduction: Impaired blood flow is an early sign of retinal dysfunction in diabetes. Impaired blood flow of the radial peripapillary capillaries can affect the Retinal Nerve Fiber Layer (RNFL) or ganglion cell function. Methods: This was an analytic cross-sectional study in February-April 2019 at Bandung. The subjects of this study were 41 people (79 eyes) divided into two groups, group A (healthy subjects) 19 people (37 eyes) and group B (DM type 2 without diabetic retinopathy) 22 people (42 eyes). Peripapillary retinal perfusion was assesed using OCT Angiography and RNFL thickness was assesed using OCT. Pearson or Spearman correlation statistics test was used to analyze the result. P value ≤0.05 was consiedered significant. Results: There was a decrease in peripapillary retinal perfusion density in the inferior quadrant (P = 0.003) and flux index throughout the peripapillary retinal quadrant (P = 0.0001) but an increase in RNFL thickness in the peripapillary temporal quadrant (P = 0.012) compared to control grup. Positive correlation was found between peripapillary retinal perfusion density and RNFL thickness globally (r = 0.480, P = 0.001), superior quadrant (r = 0.436, P = 0.004), and inferior quadrant (r = 0.608, P = 0.000). A positive correlation was also found between the peripapillary flux and RNFL thickness globally (r = 0.517, P = 0.000), superior quadrant (r = 0.630, P = 0.000), and inferior quadrant (r = 0.519, P = 0.000). Conclusions: There was a relationship between peripapillary retinal perfusion and RNFL thickness in DM patients without diabetic retinopathy. Keywords: Peripapillary perfusion, RNFL thickness, Diabetes. https://www.ijretina.com/index.php/ijretina/article/view/161 |
| spellingShingle | Sindi Dwijayanti Irawati Irfani Susanti Natalya Sirait Elsa Gustianty Erwin Iskandar R. Angga Kartiwa Relationship of Peripapillary Retinal Perfusion with Peripapillary Retinal Nerve Fiber Layer Thickness in Diabetes Mellitus Patients without Diabetic Retinopathy IJRETINA (International Journal of Retina) |
| title | Relationship of Peripapillary Retinal Perfusion with Peripapillary Retinal Nerve Fiber Layer Thickness in Diabetes Mellitus Patients without Diabetic Retinopathy |
| title_full | Relationship of Peripapillary Retinal Perfusion with Peripapillary Retinal Nerve Fiber Layer Thickness in Diabetes Mellitus Patients without Diabetic Retinopathy |
| title_fullStr | Relationship of Peripapillary Retinal Perfusion with Peripapillary Retinal Nerve Fiber Layer Thickness in Diabetes Mellitus Patients without Diabetic Retinopathy |
| title_full_unstemmed | Relationship of Peripapillary Retinal Perfusion with Peripapillary Retinal Nerve Fiber Layer Thickness in Diabetes Mellitus Patients without Diabetic Retinopathy |
| title_short | Relationship of Peripapillary Retinal Perfusion with Peripapillary Retinal Nerve Fiber Layer Thickness in Diabetes Mellitus Patients without Diabetic Retinopathy |
| title_sort | relationship of peripapillary retinal perfusion with peripapillary retinal nerve fiber layer thickness in diabetes mellitus patients without diabetic retinopathy |
| url | https://www.ijretina.com/index.php/ijretina/article/view/161 |
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