Retinochoroidal microvascular changes in newly developed obese children: an optical coherence tomography angiography study
Abstract Background Childhood obesity was associated with retinochoroidal microvascular changes using optical coherence tomography angiography (OCTA), but obesity duration was neglected. Obesity is chronic and progressive and obesity duration is related to microvascular function. Thus, it is importa...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-11-01
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| Series: | BMC Ophthalmology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12886-022-02664-9 |
| _version_ | 1811319680658309120 |
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| author | Shu Han Zhenhua Leng Xiaoxiao Li Wen Yan Shiya Shen Lei Liu Hui Zhu Dan Huang Hu Liu |
| author_facet | Shu Han Zhenhua Leng Xiaoxiao Li Wen Yan Shiya Shen Lei Liu Hui Zhu Dan Huang Hu Liu |
| author_sort | Shu Han |
| collection | DOAJ |
| description | Abstract Background Childhood obesity was associated with retinochoroidal microvascular changes using optical coherence tomography angiography (OCTA), but obesity duration was neglected. Obesity is chronic and progressive and obesity duration is related to microvascular function. Thus, it is important to identify microvascular changes in obese children timely to allow possible interventions with the increase in the number of obese children. This pilot study aimed to characterize retinochoroidal microvascular changes in newly developed obese children compared to age- and sex-matched controls. Methods Forty newly developed obese children and 40 age- and sex-matched controls were recruited. All subjects completed comprehensive eye examinations, including axial length, cycloplegic refraction, optical coherence tomography angiography scans (AngioVue; Optovue Inc), etc. Results There were no statistically significant differences between groups in terms of month age (P = 0.927), spherical equivalent refraction (P = 0.753) and axial length (P = 0.196). Newly developed obese children had lower vessel density (VD) in the inferior parafovea (P = 0.026), nasal parafovea (P = 0.038) and temporal perifovea (P = 0.026) of deep vascular complex (DVC), higher VD in the fovea of superficial vascular complex (P = 0.021) and the fovea of DVC (P = 0.016), and smaller foveal avascular zone (P = 0.003) when compared to controls. Also, no apparent differences in any quadrant of total retinal thickness, subfoveal choroidal thickness (SFCT), and choriocapillaries fow voids were detected (all P > 0.05). Conclusion Retinochoroidal microvascular changes had already occurred in newly developed obese children, so early screening and close follow-up eye examinations were recommended; Retinal microvascular insult may precede its structural change and that retina may be a better candidate to predict the onset of retinochoroidal microvascular changes than choroid in obese children. |
| first_indexed | 2024-04-13T12:46:56Z |
| format | Article |
| id | doaj.art-e12d9a23b3f6464886caffb35b40ee5d |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-04-13T12:46:56Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-e12d9a23b3f6464886caffb35b40ee5d2022-12-22T02:46:21ZengBMCBMC Ophthalmology1471-24152022-11-012211610.1186/s12886-022-02664-9Retinochoroidal microvascular changes in newly developed obese children: an optical coherence tomography angiography studyShu Han0Zhenhua Leng1Xiaoxiao Li2Wen Yan3Shiya Shen4Lei Liu5Hui Zhu6Dan Huang7Hu Liu8Department of Ophthalmology, Children’s Hospital of Soochow UniversityDepartment of Ophthalmology, The First Affiliated Hospital With Nanjing Medical UniversityDepartment of Ophthalmology, Children’s Hospital of Soochow UniversityDepartment of Ophthalmology, The Fourth Affiliated Hospital of Nantong University (Yancheng Children’s Hospital)Department of Ophthalmology, The First Affiliated Hospital With Nanjing Medical UniversitySchool of Medical Technology, Jiangsu College of NursingDepartment of Ophthalmology, The First Affiliated Hospital With Nanjing Medical UniversityDepartment of Child Healthcare, The First Affiliated Hospital With Nanjing Medical UniversityDepartment of Ophthalmology, The First Affiliated Hospital With Nanjing Medical UniversityAbstract Background Childhood obesity was associated with retinochoroidal microvascular changes using optical coherence tomography angiography (OCTA), but obesity duration was neglected. Obesity is chronic and progressive and obesity duration is related to microvascular function. Thus, it is important to identify microvascular changes in obese children timely to allow possible interventions with the increase in the number of obese children. This pilot study aimed to characterize retinochoroidal microvascular changes in newly developed obese children compared to age- and sex-matched controls. Methods Forty newly developed obese children and 40 age- and sex-matched controls were recruited. All subjects completed comprehensive eye examinations, including axial length, cycloplegic refraction, optical coherence tomography angiography scans (AngioVue; Optovue Inc), etc. Results There were no statistically significant differences between groups in terms of month age (P = 0.927), spherical equivalent refraction (P = 0.753) and axial length (P = 0.196). Newly developed obese children had lower vessel density (VD) in the inferior parafovea (P = 0.026), nasal parafovea (P = 0.038) and temporal perifovea (P = 0.026) of deep vascular complex (DVC), higher VD in the fovea of superficial vascular complex (P = 0.021) and the fovea of DVC (P = 0.016), and smaller foveal avascular zone (P = 0.003) when compared to controls. Also, no apparent differences in any quadrant of total retinal thickness, subfoveal choroidal thickness (SFCT), and choriocapillaries fow voids were detected (all P > 0.05). Conclusion Retinochoroidal microvascular changes had already occurred in newly developed obese children, so early screening and close follow-up eye examinations were recommended; Retinal microvascular insult may precede its structural change and that retina may be a better candidate to predict the onset of retinochoroidal microvascular changes than choroid in obese children.https://doi.org/10.1186/s12886-022-02664-9Newly developed obese childrenChoriocapillarisOptical coherence tomography angiographyRetinal thicknessVessel density |
| spellingShingle | Shu Han Zhenhua Leng Xiaoxiao Li Wen Yan Shiya Shen Lei Liu Hui Zhu Dan Huang Hu Liu Retinochoroidal microvascular changes in newly developed obese children: an optical coherence tomography angiography study BMC Ophthalmology Newly developed obese children Choriocapillaris Optical coherence tomography angiography Retinal thickness Vessel density |
| title | Retinochoroidal microvascular changes in newly developed obese children: an optical coherence tomography angiography study |
| title_full | Retinochoroidal microvascular changes in newly developed obese children: an optical coherence tomography angiography study |
| title_fullStr | Retinochoroidal microvascular changes in newly developed obese children: an optical coherence tomography angiography study |
| title_full_unstemmed | Retinochoroidal microvascular changes in newly developed obese children: an optical coherence tomography angiography study |
| title_short | Retinochoroidal microvascular changes in newly developed obese children: an optical coherence tomography angiography study |
| title_sort | retinochoroidal microvascular changes in newly developed obese children an optical coherence tomography angiography study |
| topic | Newly developed obese children Choriocapillaris Optical coherence tomography angiography Retinal thickness Vessel density |
| url | https://doi.org/10.1186/s12886-022-02664-9 |
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