Interrogating the haemodynamic effects of haemodialysis arteriovenous fistula on cardiac structure and function
Abstract Arteriovenous fistula (AVF) is the preferred type of vascular access for maintenance haemodialysis but it may contribute to maladaptive cardiovascular remodelling. We studied the effect of AVF creation on cardiac structure and function in patients with chronic kidney disease (CKD). In this...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-09-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-97625-5 |
| _version_ | 1831632724126859264 |
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| author | Sokratis Stoumpos Alastair Rankin Pauline Hall Barrientos Kenneth Mangion Ellon McGregor Peter C. Thomson Karen Stevenson Paul Welsh Ram Kasthuri David B. Kingsmore Giles Roditi Patrick B. Mark |
| author_facet | Sokratis Stoumpos Alastair Rankin Pauline Hall Barrientos Kenneth Mangion Ellon McGregor Peter C. Thomson Karen Stevenson Paul Welsh Ram Kasthuri David B. Kingsmore Giles Roditi Patrick B. Mark |
| author_sort | Sokratis Stoumpos |
| collection | DOAJ |
| description | Abstract Arteriovenous fistula (AVF) is the preferred type of vascular access for maintenance haemodialysis but it may contribute to maladaptive cardiovascular remodelling. We studied the effect of AVF creation on cardiac structure and function in patients with chronic kidney disease (CKD). In this prospective cohort study patients with CKD listed for first AVF creation underwent cardiac magnetic resonance (CMR) imaging at baseline and at 6 weeks. All participants had ultrasound measurements of fistula blood flow at 6 weeks. The primary outcome was the change in left ventricular (LV) mass. Secondary outcomes included changes in LV volumes, LV ejection fraction, cardiac output, LV global longitudinal strain and N-terminal-pro B-type natriuretic peptide (NT-proBNP). A total of 55 participants were enrolled, of whom 40 (mean age 59 years) had AVF creation and completed both scans. On the second CMR scan, a mean increase of 7.4 g (95% CI 1.1–13.7, p = 0.02) was observed in LV mass. Significant increases in LV end-diastolic volumes (p = 0.04) and cardiac output (p = 0.02) were also seen after AVF creation. No significant changes were observed in LV end-systolic volumes, LV ejection fraction, NT-proBNP and LV global longitudinal strain. In participants with fistula blood flows ≥ 600 mL/min (n = 22) the mean increase in LV mass was 15.5 g (95% CI 7.3–23.8) compared with a small decrease of 2.5 g (95% CI − 10.6 to 5.6) in participants with blood flows < 600 mL/min (n = 18). Creation of AVF for haemodialysis resulted in a significant increase of LV myocardial mass within weeks after surgery, which was proportional to the fistula flow. |
| first_indexed | 2024-12-19T05:24:55Z |
| format | Article |
| id | doaj.art-e12e84dfdb1a44aaa2cc44d11198b508 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-19T05:24:55Z |
| publishDate | 2021-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-e12e84dfdb1a44aaa2cc44d11198b5082022-12-21T20:34:25ZengNature PortfolioScientific Reports2045-23222021-09-011111910.1038/s41598-021-97625-5Interrogating the haemodynamic effects of haemodialysis arteriovenous fistula on cardiac structure and functionSokratis Stoumpos0Alastair Rankin1Pauline Hall Barrientos2Kenneth Mangion3Ellon McGregor4Peter C. Thomson5Karen Stevenson6Paul Welsh7Ram Kasthuri8David B. Kingsmore9Giles Roditi10Patrick B. Mark11Institute of Cardiovascular and Medical Sciences, University of GlasgowInstitute of Cardiovascular and Medical Sciences, University of GlasgowDepartment of Radiology, Queen Elizabeth University HospitalInstitute of Cardiovascular and Medical Sciences, University of GlasgowRenal & Transplant Unit, Queen Elizabeth University HospitalRenal & Transplant Unit, Queen Elizabeth University HospitalRenal & Transplant Unit, Queen Elizabeth University HospitalInstitute of Cardiovascular and Medical Sciences, University of GlasgowDepartment of Radiology, Queen Elizabeth University HospitalRenal & Transplant Unit, Queen Elizabeth University HospitalDepartment of Radiology, Queen Elizabeth University HospitalInstitute of Cardiovascular and Medical Sciences, University of GlasgowAbstract Arteriovenous fistula (AVF) is the preferred type of vascular access for maintenance haemodialysis but it may contribute to maladaptive cardiovascular remodelling. We studied the effect of AVF creation on cardiac structure and function in patients with chronic kidney disease (CKD). In this prospective cohort study patients with CKD listed for first AVF creation underwent cardiac magnetic resonance (CMR) imaging at baseline and at 6 weeks. All participants had ultrasound measurements of fistula blood flow at 6 weeks. The primary outcome was the change in left ventricular (LV) mass. Secondary outcomes included changes in LV volumes, LV ejection fraction, cardiac output, LV global longitudinal strain and N-terminal-pro B-type natriuretic peptide (NT-proBNP). A total of 55 participants were enrolled, of whom 40 (mean age 59 years) had AVF creation and completed both scans. On the second CMR scan, a mean increase of 7.4 g (95% CI 1.1–13.7, p = 0.02) was observed in LV mass. Significant increases in LV end-diastolic volumes (p = 0.04) and cardiac output (p = 0.02) were also seen after AVF creation. No significant changes were observed in LV end-systolic volumes, LV ejection fraction, NT-proBNP and LV global longitudinal strain. In participants with fistula blood flows ≥ 600 mL/min (n = 22) the mean increase in LV mass was 15.5 g (95% CI 7.3–23.8) compared with a small decrease of 2.5 g (95% CI − 10.6 to 5.6) in participants with blood flows < 600 mL/min (n = 18). Creation of AVF for haemodialysis resulted in a significant increase of LV myocardial mass within weeks after surgery, which was proportional to the fistula flow.https://doi.org/10.1038/s41598-021-97625-5 |
| spellingShingle | Sokratis Stoumpos Alastair Rankin Pauline Hall Barrientos Kenneth Mangion Ellon McGregor Peter C. Thomson Karen Stevenson Paul Welsh Ram Kasthuri David B. Kingsmore Giles Roditi Patrick B. Mark Interrogating the haemodynamic effects of haemodialysis arteriovenous fistula on cardiac structure and function Scientific Reports |
| title | Interrogating the haemodynamic effects of haemodialysis arteriovenous fistula on cardiac structure and function |
| title_full | Interrogating the haemodynamic effects of haemodialysis arteriovenous fistula on cardiac structure and function |
| title_fullStr | Interrogating the haemodynamic effects of haemodialysis arteriovenous fistula on cardiac structure and function |
| title_full_unstemmed | Interrogating the haemodynamic effects of haemodialysis arteriovenous fistula on cardiac structure and function |
| title_short | Interrogating the haemodynamic effects of haemodialysis arteriovenous fistula on cardiac structure and function |
| title_sort | interrogating the haemodynamic effects of haemodialysis arteriovenous fistula on cardiac structure and function |
| url | https://doi.org/10.1038/s41598-021-97625-5 |
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