Inflammation and insulin resistance in adipose tissue
Background. Adipose tissue is today well established as a complex and active endocrine organ. The adipose tissue secretes a number of cytokines, adipokines, which act both locally and systemically. The adipose tissue in normal weight people has anti-inflammatory properties, but in overweight / obesi...
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| Format: | Article |
| Language: | Danish |
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NITO - Bioingeniørfaglig institutt
2021-05-01
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| Series: | Bioingeniøren |
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| Online Access: | https://bioingenioren.no/fag/fag-oversiktsartikkel/inflammasjon-og-insulinresistens-i-fettvev/ |
| _version_ | 1828748424459059200 |
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| author | Sissel Åkra |
| author_facet | Sissel Åkra |
| author_sort | Sissel Åkra |
| collection | DOAJ |
| description | Background. Adipose tissue is today well established as a complex and active endocrine organ. The adipose tissue secretes a number of cytokines, adipokines, which act both locally and systemically. The adipose tissue in normal weight people has anti-inflammatory properties, but in overweight / obesity the adipose tissue is exposed to various forms of cellular stress which results in increased production of pro-inflammatory cytokines. This causes a chronic low-grade inflammation that is associated with a number of metabolic diseases such as insulin resistance and type 2 diabetes and to atherosclerotic heart diseases.
Material and method. This review article is based on non-systematic searches in PubMed and mainly on the author's experience through her own and others' research at the Center for Clinical Heart Research, Department of Cardiology, Oslo University Hospital Ullevål.
Discussion. A lot of research has been performed to sort out and understand the mechanisms behind adipose tissue inflammation as related to obesity, insulin resistance and diabetes, and several strategies have been tried to inhibit pro-inflammatory signaling. Further research and methodological development provide opportunities for better and more targeted treatment strategies for the increasing burden of metabolic diseases linked to overweight and obesity.
Although dietary changes and increased physical activity still are the most important strategies to reduce weight, there is still a need for alternative forms of treatment. |
| first_indexed | 2024-04-14T05:01:08Z |
| format | Article |
| id | doaj.art-e12eaadcf4da47a89a6a1fe7b586ccb3 |
| institution | Directory Open Access Journal |
| issn | 0801-6828 1890-1875 |
| language | Danish |
| last_indexed | 2024-04-14T05:01:08Z |
| publishDate | 2021-05-01 |
| publisher | NITO - Bioingeniørfaglig institutt |
| record_format | Article |
| series | Bioingeniøren |
| spelling | doaj.art-e12eaadcf4da47a89a6a1fe7b586ccb32022-12-22T02:10:58ZdanNITO - Bioingeniørfaglig instituttBioingeniøren0801-68281890-18752021-05-015653236Inflammation and insulin resistance in adipose tissueSissel Åkra0Oslo universitetssykehus - Ullevål Background. Adipose tissue is today well established as a complex and active endocrine organ. The adipose tissue secretes a number of cytokines, adipokines, which act both locally and systemically. The adipose tissue in normal weight people has anti-inflammatory properties, but in overweight / obesity the adipose tissue is exposed to various forms of cellular stress which results in increased production of pro-inflammatory cytokines. This causes a chronic low-grade inflammation that is associated with a number of metabolic diseases such as insulin resistance and type 2 diabetes and to atherosclerotic heart diseases. Material and method. This review article is based on non-systematic searches in PubMed and mainly on the author's experience through her own and others' research at the Center for Clinical Heart Research, Department of Cardiology, Oslo University Hospital Ullevål. Discussion. A lot of research has been performed to sort out and understand the mechanisms behind adipose tissue inflammation as related to obesity, insulin resistance and diabetes, and several strategies have been tried to inhibit pro-inflammatory signaling. Further research and methodological development provide opportunities for better and more targeted treatment strategies for the increasing burden of metabolic diseases linked to overweight and obesity. Although dietary changes and increased physical activity still are the most important strategies to reduce weight, there is still a need for alternative forms of treatment.https://bioingenioren.no/fag/fag-oversiktsartikkel/inflammasjon-og-insulinresistens-i-fettvev/adipose tissueobesityinflammationinsulin resistance |
| spellingShingle | Sissel Åkra Inflammation and insulin resistance in adipose tissue Bioingeniøren adipose tissue obesity inflammation insulin resistance |
| title | Inflammation and insulin resistance in adipose tissue |
| title_full | Inflammation and insulin resistance in adipose tissue |
| title_fullStr | Inflammation and insulin resistance in adipose tissue |
| title_full_unstemmed | Inflammation and insulin resistance in adipose tissue |
| title_short | Inflammation and insulin resistance in adipose tissue |
| title_sort | inflammation and insulin resistance in adipose tissue |
| topic | adipose tissue obesity inflammation insulin resistance |
| url | https://bioingenioren.no/fag/fag-oversiktsartikkel/inflammasjon-og-insulinresistens-i-fettvev/ |
| work_keys_str_mv | AT sisselakra inflammationandinsulinresistanceinadiposetissue |