Development of a Novel Electrochemical Sensor for Determination of Matrine in Sophora flavescens
A simple and sensitive electrochemical sensor fabricated with graphene nanosheets (GNs) and a hydroxyapatite (HA) nanocomposite–modified glassy carbon electrode (GCE) was developed for the determination of matrine (MT). The as-prepared electrode (GNs/HA/GCE) was verified to outperform bare a GCE and...
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| Format: | Article |
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MDPI AG
2017-04-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/22/4/575 |
| _version_ | 1818658428066725888 |
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| author | Junping Zhang Yanchun Wang Wei Zheng |
| author_facet | Junping Zhang Yanchun Wang Wei Zheng |
| author_sort | Junping Zhang |
| collection | DOAJ |
| description | A simple and sensitive electrochemical sensor fabricated with graphene nanosheets (GNs) and a hydroxyapatite (HA) nanocomposite–modified glassy carbon electrode (GCE) was developed for the determination of matrine (MT). The as-prepared electrode (GNs/HA/GCE) was verified to outperform bare a GCE and GNs-modified electrode with increased oxidation peak currents and the decreased over-potential in the redox process of MT, indicating the great enhancement of electrocatalytic activity toward the oxidation of MT by the composite of GNs and HA. Under the optimized conditions, the oxidation peak currents were related linearly with the concentration of MT, ranging from 2 μM to 3 mM, and the detection limit (S/N = 3) was 1.2 μM. In addition, the proposed electrochemical sensor can be successfully applied in the quantitative determination of MT in Sophora flavescens extract. |
| first_indexed | 2024-12-17T03:57:13Z |
| format | Article |
| id | doaj.art-e12fb0949f9345aea3d4da21739e5dc5 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-17T03:57:13Z |
| publishDate | 2017-04-01 |
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| series | Molecules |
| spelling | doaj.art-e12fb0949f9345aea3d4da21739e5dc52022-12-21T22:04:36ZengMDPI AGMolecules1420-30492017-04-0122457510.3390/molecules22040575molecules22040575Development of a Novel Electrochemical Sensor for Determination of Matrine in Sophora flavescensJunping Zhang0Yanchun Wang1Wei Zheng2Department of Oncology, Henan Academy institute of Traditional Chinese Medicine, Zhengzhou 450000, Henan, ChinaDepartment of Traditional Chinese Medicine, Henan Province People's Hospital, Zhengzhou 450002, Henan, ChinaDepartment of Oncology, Henan Academy institute of Traditional Chinese Medicine, Zhengzhou 450000, Henan, ChinaA simple and sensitive electrochemical sensor fabricated with graphene nanosheets (GNs) and a hydroxyapatite (HA) nanocomposite–modified glassy carbon electrode (GCE) was developed for the determination of matrine (MT). The as-prepared electrode (GNs/HA/GCE) was verified to outperform bare a GCE and GNs-modified electrode with increased oxidation peak currents and the decreased over-potential in the redox process of MT, indicating the great enhancement of electrocatalytic activity toward the oxidation of MT by the composite of GNs and HA. Under the optimized conditions, the oxidation peak currents were related linearly with the concentration of MT, ranging from 2 μM to 3 mM, and the detection limit (S/N = 3) was 1.2 μM. In addition, the proposed electrochemical sensor can be successfully applied in the quantitative determination of MT in Sophora flavescens extract.http://www.mdpi.com/1420-3049/22/4/575matrinevoltammetric sensorsSophora flavescenselectrochemistryhydroxyapatite |
| spellingShingle | Junping Zhang Yanchun Wang Wei Zheng Development of a Novel Electrochemical Sensor for Determination of Matrine in Sophora flavescens Molecules matrine voltammetric sensors Sophora flavescens electrochemistry hydroxyapatite |
| title | Development of a Novel Electrochemical Sensor for Determination of Matrine in Sophora flavescens |
| title_full | Development of a Novel Electrochemical Sensor for Determination of Matrine in Sophora flavescens |
| title_fullStr | Development of a Novel Electrochemical Sensor for Determination of Matrine in Sophora flavescens |
| title_full_unstemmed | Development of a Novel Electrochemical Sensor for Determination of Matrine in Sophora flavescens |
| title_short | Development of a Novel Electrochemical Sensor for Determination of Matrine in Sophora flavescens |
| title_sort | development of a novel electrochemical sensor for determination of matrine in sophora flavescens |
| topic | matrine voltammetric sensors Sophora flavescens electrochemistry hydroxyapatite |
| url | http://www.mdpi.com/1420-3049/22/4/575 |
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