Structure and function of the membrane microdomains in osteoclasts
Abstract The cell membrane structure is closely related to the occurrence and progression of many metabolic bone diseases observed in the clinic and is an important target to the development of therapeutic strategies for these diseases. Strong experimental evidence supports the existence of membrane...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2023-11-01
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| Series: | Bone Research |
| Online Access: | https://doi.org/10.1038/s41413-023-00294-5 |
| _version_ | 1797453641764831232 |
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| author | Jialong Hou Jian Liu Zhixian Huang Yining Wang Hanbing Yao Zhenxin Hu Chengge Shi Jiake Xu Qingqing Wang |
| author_facet | Jialong Hou Jian Liu Zhixian Huang Yining Wang Hanbing Yao Zhenxin Hu Chengge Shi Jiake Xu Qingqing Wang |
| author_sort | Jialong Hou |
| collection | DOAJ |
| description | Abstract The cell membrane structure is closely related to the occurrence and progression of many metabolic bone diseases observed in the clinic and is an important target to the development of therapeutic strategies for these diseases. Strong experimental evidence supports the existence of membrane microdomains in osteoclasts (OCs). However, the potential membrane microdomains and the crucial mechanisms underlying their roles in OCs have not been fully characterized. Membrane microdomain components, such as scaffolding proteins and the actin cytoskeleton, as well as the roles of individual membrane proteins, need to be elucidated. In this review, we discuss the compositions and critical functions of membrane microdomains that determine the biological behavior of OCs through the three main stages of the OC life cycle. |
| first_indexed | 2024-03-09T15:25:46Z |
| format | Article |
| id | doaj.art-e130946ee48246f5a987b7524ff3b2a6 |
| institution | Directory Open Access Journal |
| issn | 2095-6231 |
| language | English |
| last_indexed | 2024-03-09T15:25:46Z |
| publishDate | 2023-11-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Bone Research |
| spelling | doaj.art-e130946ee48246f5a987b7524ff3b2a62023-11-26T12:35:40ZengNature Publishing GroupBone Research2095-62312023-11-0111111410.1038/s41413-023-00294-5Structure and function of the membrane microdomains in osteoclastsJialong Hou0Jian Liu1Zhixian Huang2Yining Wang3Hanbing Yao4Zhenxin Hu5Chengge Shi6Jiake Xu7Qingqing Wang8Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of MedicineDepartment of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of MedicineDepartment of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of MedicineDepartment of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of MedicineDepartment of Orthopaedics, The First Affiliated Hospital of Wenzhou Medical UniversityDepartment of Spine Surgery, Peking University Fourth School of Clinical MedicineDepartment of Orthopaedics, The First Affiliated Hospital of Wenzhou Medical UniversitySchool of Biomedical Sciences, The University of Western AustraliaDepartment of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of MedicineAbstract The cell membrane structure is closely related to the occurrence and progression of many metabolic bone diseases observed in the clinic and is an important target to the development of therapeutic strategies for these diseases. Strong experimental evidence supports the existence of membrane microdomains in osteoclasts (OCs). However, the potential membrane microdomains and the crucial mechanisms underlying their roles in OCs have not been fully characterized. Membrane microdomain components, such as scaffolding proteins and the actin cytoskeleton, as well as the roles of individual membrane proteins, need to be elucidated. In this review, we discuss the compositions and critical functions of membrane microdomains that determine the biological behavior of OCs through the three main stages of the OC life cycle.https://doi.org/10.1038/s41413-023-00294-5 |
| spellingShingle | Jialong Hou Jian Liu Zhixian Huang Yining Wang Hanbing Yao Zhenxin Hu Chengge Shi Jiake Xu Qingqing Wang Structure and function of the membrane microdomains in osteoclasts Bone Research |
| title | Structure and function of the membrane microdomains in osteoclasts |
| title_full | Structure and function of the membrane microdomains in osteoclasts |
| title_fullStr | Structure and function of the membrane microdomains in osteoclasts |
| title_full_unstemmed | Structure and function of the membrane microdomains in osteoclasts |
| title_short | Structure and function of the membrane microdomains in osteoclasts |
| title_sort | structure and function of the membrane microdomains in osteoclasts |
| url | https://doi.org/10.1038/s41413-023-00294-5 |
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