Serological evidence of Zika virus circulation with dengue and chikungunya infections in Sri Lanka from 2017
Introduction: Arbovirus diseases remain a public health threat in Sri Lanka. Dengue is endemic and two outbreaks of chikungunya infections have been reported. There is limited data on Zika virus (ZIKV) infections in Sri Lanka, and this could be due to a lack of comprehensive ZIKV surveillance. Our a...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Journal of Global Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.jgid.org/article.asp?issn=0974-777X;year=2023;volume=15;issue=3;spage=113;epage=120;aulast=Abeygoonawardena |
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| author | Harshi Abeygoonawardena Namal Wijesinghe Varuna Navaratne Aindrala Balasuriya Thi Thanh Ngan Nguyen Meng Ling Moi Aruna Dharshan De Silva |
| author_facet | Harshi Abeygoonawardena Namal Wijesinghe Varuna Navaratne Aindrala Balasuriya Thi Thanh Ngan Nguyen Meng Ling Moi Aruna Dharshan De Silva |
| author_sort | Harshi Abeygoonawardena |
| collection | DOAJ |
| description | Introduction: Arbovirus diseases remain a public health threat in Sri Lanka. Dengue is endemic and two outbreaks of chikungunya infections have been reported. There is limited data on Zika virus (ZIKV) infections in Sri Lanka, and this could be due to a lack of comprehensive ZIKV surveillance. Our aim was to determine the presence of antibodies to dengue, chikungunya, and Zika infections in adults from a suburban population in Sri Lanka. Methods: A total of 149 healthy adult volunteers over 18 years of age (mean age: 43±14 years, males – 43%), with no prior diagnosed arboviral infections and no history of overseas travel, participated in the study. ELISA and neutralization assays were carried out to detect past dengue, chikungunya, or Zika infections. Results: A total of 94.6% (141/149) of the participants demonstrated dengue IgG antibodies, 37.5% (56/149) were positive for chikungunya IgG, and 5.3% (8/149) were positive for anti-ZIKV IgG antibodies. Neutralization assays confirmed ZIKV-specific antibodies in 6.7% (10/149), when 40/149 of the participating population were tested. Conclusion: This clearly demonstrated past ZIKV infections in this population. In addition, this study indicates that >90% of individuals had asymptomatic dengue but no serious symptoms. These results provide a cross-sectional view on the DENV, ZIKV, and CHIKV epidemic status and demonstrate a need for the implementation of enhanced surveillance and more effective measures against the spread of these arbovirus diseases. |
| first_indexed | 2024-03-11T14:50:17Z |
| format | Article |
| id | doaj.art-e130e2ecd0f846cc8380ab49a64829ec |
| institution | Directory Open Access Journal |
| issn | 0974-777X |
| language | English |
| last_indexed | 2024-03-11T14:50:17Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Global Infectious Diseases |
| spelling | doaj.art-e130e2ecd0f846cc8380ab49a64829ec2023-10-30T09:49:20ZengWolters Kluwer Medknow PublicationsJournal of Global Infectious Diseases0974-777X2023-01-0115311312010.4103/jgid.jgid_195_22Serological evidence of Zika virus circulation with dengue and chikungunya infections in Sri Lanka from 2017Harshi AbeygoonawardenaNamal WijesingheVaruna NavaratneAindrala BalasuriyaThi Thanh Ngan NguyenMeng Ling MoiAruna Dharshan De SilvaIntroduction: Arbovirus diseases remain a public health threat in Sri Lanka. Dengue is endemic and two outbreaks of chikungunya infections have been reported. There is limited data on Zika virus (ZIKV) infections in Sri Lanka, and this could be due to a lack of comprehensive ZIKV surveillance. Our aim was to determine the presence of antibodies to dengue, chikungunya, and Zika infections in adults from a suburban population in Sri Lanka. Methods: A total of 149 healthy adult volunteers over 18 years of age (mean age: 43±14 years, males – 43%), with no prior diagnosed arboviral infections and no history of overseas travel, participated in the study. ELISA and neutralization assays were carried out to detect past dengue, chikungunya, or Zika infections. Results: A total of 94.6% (141/149) of the participants demonstrated dengue IgG antibodies, 37.5% (56/149) were positive for chikungunya IgG, and 5.3% (8/149) were positive for anti-ZIKV IgG antibodies. Neutralization assays confirmed ZIKV-specific antibodies in 6.7% (10/149), when 40/149 of the participating population were tested. Conclusion: This clearly demonstrated past ZIKV infections in this population. In addition, this study indicates that >90% of individuals had asymptomatic dengue but no serious symptoms. These results provide a cross-sectional view on the DENV, ZIKV, and CHIKV epidemic status and demonstrate a need for the implementation of enhanced surveillance and more effective measures against the spread of these arbovirus diseases.http://www.jgid.org/article.asp?issn=0974-777X;year=2023;volume=15;issue=3;spage=113;epage=120;aulast=Abeygoonawardenachikungunyadengueenzyme-linked immunosorbent assayiggneutralization assayszika |
| spellingShingle | Harshi Abeygoonawardena Namal Wijesinghe Varuna Navaratne Aindrala Balasuriya Thi Thanh Ngan Nguyen Meng Ling Moi Aruna Dharshan De Silva Serological evidence of Zika virus circulation with dengue and chikungunya infections in Sri Lanka from 2017 Journal of Global Infectious Diseases chikungunya dengue enzyme-linked immunosorbent assay igg neutralization assays zika |
| title | Serological evidence of Zika virus circulation with dengue and chikungunya infections in Sri Lanka from 2017 |
| title_full | Serological evidence of Zika virus circulation with dengue and chikungunya infections in Sri Lanka from 2017 |
| title_fullStr | Serological evidence of Zika virus circulation with dengue and chikungunya infections in Sri Lanka from 2017 |
| title_full_unstemmed | Serological evidence of Zika virus circulation with dengue and chikungunya infections in Sri Lanka from 2017 |
| title_short | Serological evidence of Zika virus circulation with dengue and chikungunya infections in Sri Lanka from 2017 |
| title_sort | serological evidence of zika virus circulation with dengue and chikungunya infections in sri lanka from 2017 |
| topic | chikungunya dengue enzyme-linked immunosorbent assay igg neutralization assays zika |
| url | http://www.jgid.org/article.asp?issn=0974-777X;year=2023;volume=15;issue=3;spage=113;epage=120;aulast=Abeygoonawardena |
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