Tumor and Nodal Disease Growth Rates in Patients with Oropharyngeal Squamous Cell Carcinoma
Though specific growth rate (SGR) has potential prognostic value for oropharyngeal squamous cell carcinoma (OPSCC), there is sparse literature defining these rates. Our aims were to establish the SGRs of primary tumors (PTs) and lymph nodes (LNs) in OPSCC and to correlate SGR with oncologic outcome....
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/15/3865 |
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| author | Nicole I. Farber Yimin Li Roberto N. Solis Joy Chen Zahrah Masheeb Machelle Wilson Arnaud F. Bewley Marianne Abouyared Shyam Rao Yi Rong Andrew C. Birkeland |
| author_facet | Nicole I. Farber Yimin Li Roberto N. Solis Joy Chen Zahrah Masheeb Machelle Wilson Arnaud F. Bewley Marianne Abouyared Shyam Rao Yi Rong Andrew C. Birkeland |
| author_sort | Nicole I. Farber |
| collection | DOAJ |
| description | Though specific growth rate (SGR) has potential prognostic value for oropharyngeal squamous cell carcinoma (OPSCC), there is sparse literature defining these rates. Our aims were to establish the SGRs of primary tumors (PTs) and lymph nodes (LNs) in OPSCC and to correlate SGR with oncologic outcome. A pilot study was designed with a retrospective analysis examining 54 patients from the University of California, Davis with OPSCC (diagnosed 2012–2019). Radiation oncology software and pretreatment serial CT scans were used to measure PT and LN volumes to calculate SGR and doubling time (DT). The mean PT-SGR was 1.2 ± 2.2%/day and the mean LN-SGR was 1.6 ± 1.9%/day. There was no statistically significant difference between slow-growing and fast-growing cohorts in terms of age, gender, smoking status, tumor subsite, HPV status (as determined with p16 staining), initial volume, or overall stage. SGR had no impact on 2-year overall survival, disease-free survival, or disease-specific survival. We found the average daily growth rates for OPSCC to be 1.2%/day and 1.6%/day. Our findings suggest PT- and LN-SGR are independent factors, not heavily influenced by known biomarkers and patient characteristics, without a statistical impact on prognosis. This information has value in patient counseling regarding tumor growth and in providing patients worried about fast-growing tumors the appropriate reassurance. |
| first_indexed | 2024-03-11T00:30:49Z |
| format | Article |
| id | doaj.art-e1327c7731e544cb93223c5fc7251b6a |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T00:30:49Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-e1327c7731e544cb93223c5fc7251b6a2023-11-18T22:42:27ZengMDPI AGCancers2072-66942023-07-011515386510.3390/cancers15153865Tumor and Nodal Disease Growth Rates in Patients with Oropharyngeal Squamous Cell CarcinomaNicole I. Farber0Yimin Li1Roberto N. Solis2Joy Chen3Zahrah Masheeb4Machelle Wilson5Arnaud F. Bewley6Marianne Abouyared7Shyam Rao8Yi Rong9Andrew C. Birkeland10Department of Otolaryngology-Head and Neck Surgery, University of California Davis, Sacramento, CA 95817, USADepartment of Radiation Oncology, University of California Davis, Sacramento, CA 94720, USADepartment of Otolaryngology-Head and Neck Surgery, University of California Davis, Sacramento, CA 95817, USADepartment of Otolaryngology-Head and Neck Surgery, University of California Davis, Sacramento, CA 95817, USADepartment of Otolaryngology-Head and Neck Surgery, University of California Davis, Sacramento, CA 95817, USADavis-School of Medicine, University of California, Sacramento, CA 94720, USADepartment of Otolaryngology-Head and Neck Surgery, University of California Davis, Sacramento, CA 95817, USADepartment of Otolaryngology-Head and Neck Surgery, University of California Davis, Sacramento, CA 95817, USADepartment of Radiation Oncology, University of California Davis, Sacramento, CA 94720, USADepartment of Radiation Oncology, University of California Davis, Sacramento, CA 94720, USADepartment of Otolaryngology-Head and Neck Surgery, University of California Davis, Sacramento, CA 95817, USAThough specific growth rate (SGR) has potential prognostic value for oropharyngeal squamous cell carcinoma (OPSCC), there is sparse literature defining these rates. Our aims were to establish the SGRs of primary tumors (PTs) and lymph nodes (LNs) in OPSCC and to correlate SGR with oncologic outcome. A pilot study was designed with a retrospective analysis examining 54 patients from the University of California, Davis with OPSCC (diagnosed 2012–2019). Radiation oncology software and pretreatment serial CT scans were used to measure PT and LN volumes to calculate SGR and doubling time (DT). The mean PT-SGR was 1.2 ± 2.2%/day and the mean LN-SGR was 1.6 ± 1.9%/day. There was no statistically significant difference between slow-growing and fast-growing cohorts in terms of age, gender, smoking status, tumor subsite, HPV status (as determined with p16 staining), initial volume, or overall stage. SGR had no impact on 2-year overall survival, disease-free survival, or disease-specific survival. We found the average daily growth rates for OPSCC to be 1.2%/day and 1.6%/day. Our findings suggest PT- and LN-SGR are independent factors, not heavily influenced by known biomarkers and patient characteristics, without a statistical impact on prognosis. This information has value in patient counseling regarding tumor growth and in providing patients worried about fast-growing tumors the appropriate reassurance.https://www.mdpi.com/2072-6694/15/15/3865oropharyngealtumor growthsquamous cell carcinoma |
| spellingShingle | Nicole I. Farber Yimin Li Roberto N. Solis Joy Chen Zahrah Masheeb Machelle Wilson Arnaud F. Bewley Marianne Abouyared Shyam Rao Yi Rong Andrew C. Birkeland Tumor and Nodal Disease Growth Rates in Patients with Oropharyngeal Squamous Cell Carcinoma Cancers oropharyngeal tumor growth squamous cell carcinoma |
| title | Tumor and Nodal Disease Growth Rates in Patients with Oropharyngeal Squamous Cell Carcinoma |
| title_full | Tumor and Nodal Disease Growth Rates in Patients with Oropharyngeal Squamous Cell Carcinoma |
| title_fullStr | Tumor and Nodal Disease Growth Rates in Patients with Oropharyngeal Squamous Cell Carcinoma |
| title_full_unstemmed | Tumor and Nodal Disease Growth Rates in Patients with Oropharyngeal Squamous Cell Carcinoma |
| title_short | Tumor and Nodal Disease Growth Rates in Patients with Oropharyngeal Squamous Cell Carcinoma |
| title_sort | tumor and nodal disease growth rates in patients with oropharyngeal squamous cell carcinoma |
| topic | oropharyngeal tumor growth squamous cell carcinoma |
| url | https://www.mdpi.com/2072-6694/15/15/3865 |
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