Adjunct therapy with probiotics for depressive episodes of bipolar disorder type Ⅰ: A randomized placebo-controlled trial
Background: Probiotics adjuvant therapy might enhance the efficacy of the conventional medications of bipolar disorder type Ⅰ (BD-Ⅰ). Methods: A randomized double-blind placebo-controlled design was implemented in this study. We randomly assigned 98 patients with depressive BD-Ⅰ to receive the combi...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464623001536 |
| _version_ | 1797819916913475584 |
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| author | Jian-zhao Zhang Fang-yuan Zhu En-xu Feng Fei Wu Xin Fang Huai-jun Tu Jin Wei Ai-lan Wan Ting-tao Chen |
| author_facet | Jian-zhao Zhang Fang-yuan Zhu En-xu Feng Fei Wu Xin Fang Huai-jun Tu Jin Wei Ai-lan Wan Ting-tao Chen |
| author_sort | Jian-zhao Zhang |
| collection | DOAJ |
| description | Background: Probiotics adjuvant therapy might enhance the efficacy of the conventional medications of bipolar disorder type Ⅰ (BD-Ⅰ). Methods: A randomized double-blind placebo-controlled design was implemented in this study. We randomly assigned 98 patients with depressive BD-Ⅰ to receive the combined treatment of probiotics (Bifidobacterium animals subsp. lactis BAMA-B06/BAu-B0111, 2 g/day) (N = 49) and conventional medications, or conventional medications along with placebo (maltodextrin, 2 g/day) (N = 49). Primary endpoints were the change from baseline to 30 days in the scores of 17-item Hamilton Depression Rating Scale. Results: Compared with control group, HAMD-14 scores were further decreased significantly and the increase trend of fasting blood glucose were suppressed in treatment group. Subsequent correlation analysis revealed there were close associations between the relative abundance of Firmicutes, serum levels of fasting blood glucose and HAMD-14 scores. Conclusions: Probiotics adjuvant therapy can enhance the efficacy of the conventional medications of depressive BD-Ⅰ and reduce the metabolic side effects. |
| first_indexed | 2024-03-13T09:29:39Z |
| format | Article |
| id | doaj.art-e1329a47d07f4c569dc6e4bc12ef8c28 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-03-13T09:29:39Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-e1329a47d07f4c569dc6e4bc12ef8c282023-05-26T04:21:09ZengElsevierJournal of Functional Foods1756-46462023-06-01105105553Adjunct therapy with probiotics for depressive episodes of bipolar disorder type Ⅰ: A randomized placebo-controlled trialJian-zhao Zhang0Fang-yuan Zhu1En-xu Feng2Fei Wu3Xin Fang4Huai-jun Tu5Jin Wei6Ai-lan Wan7Ting-tao Chen8Department of Psychiatry, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, ChinaQueen Mary School, Nanchang University, Nanchang, Jiangxi 330006, ChinaCollege of Food Science and Engineering, Shandong Agricultural University, Taian, Shangdong 271018, ChinaDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, ChinaDepartment of Neurology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, ChinaDepartments of Geriatrics, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330031, ChinaInstitute of Translational Medicine, Nanchang University, Nanchang, Jiangxi 330006, ChinaDepartment of Psychiatry, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China; Corresponding authors at: Department of Psychiatry, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China.Department of Psychiatry, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China; Institute of Translational Medicine, Nanchang University, Nanchang, Jiangxi 330006, China; Corresponding authors at: Department of Psychiatry, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China.Background: Probiotics adjuvant therapy might enhance the efficacy of the conventional medications of bipolar disorder type Ⅰ (BD-Ⅰ). Methods: A randomized double-blind placebo-controlled design was implemented in this study. We randomly assigned 98 patients with depressive BD-Ⅰ to receive the combined treatment of probiotics (Bifidobacterium animals subsp. lactis BAMA-B06/BAu-B0111, 2 g/day) (N = 49) and conventional medications, or conventional medications along with placebo (maltodextrin, 2 g/day) (N = 49). Primary endpoints were the change from baseline to 30 days in the scores of 17-item Hamilton Depression Rating Scale. Results: Compared with control group, HAMD-14 scores were further decreased significantly and the increase trend of fasting blood glucose were suppressed in treatment group. Subsequent correlation analysis revealed there were close associations between the relative abundance of Firmicutes, serum levels of fasting blood glucose and HAMD-14 scores. Conclusions: Probiotics adjuvant therapy can enhance the efficacy of the conventional medications of depressive BD-Ⅰ and reduce the metabolic side effects.http://www.sciencedirect.com/science/article/pii/S1756464623001536Bipolar disorderProbioticsGut microbiotaAdjunct therapyMetabolic disorders |
| spellingShingle | Jian-zhao Zhang Fang-yuan Zhu En-xu Feng Fei Wu Xin Fang Huai-jun Tu Jin Wei Ai-lan Wan Ting-tao Chen Adjunct therapy with probiotics for depressive episodes of bipolar disorder type Ⅰ: A randomized placebo-controlled trial Journal of Functional Foods Bipolar disorder Probiotics Gut microbiota Adjunct therapy Metabolic disorders |
| title | Adjunct therapy with probiotics for depressive episodes of bipolar disorder type Ⅰ: A randomized placebo-controlled trial |
| title_full | Adjunct therapy with probiotics for depressive episodes of bipolar disorder type Ⅰ: A randomized placebo-controlled trial |
| title_fullStr | Adjunct therapy with probiotics for depressive episodes of bipolar disorder type Ⅰ: A randomized placebo-controlled trial |
| title_full_unstemmed | Adjunct therapy with probiotics for depressive episodes of bipolar disorder type Ⅰ: A randomized placebo-controlled trial |
| title_short | Adjunct therapy with probiotics for depressive episodes of bipolar disorder type Ⅰ: A randomized placebo-controlled trial |
| title_sort | adjunct therapy with probiotics for depressive episodes of bipolar disorder type i a randomized placebo controlled trial |
| topic | Bipolar disorder Probiotics Gut microbiota Adjunct therapy Metabolic disorders |
| url | http://www.sciencedirect.com/science/article/pii/S1756464623001536 |
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