Timeline of changes in spike conformational dynamics in emergent SARS-CoV-2 variants reveal progressive stabilization of trimer stalk with altered NTD dynamics
SARS-CoV-2 emergent variants are characterized by increased viral fitness and each shows multiple mutations predominantly localized to the spike (S) protein. Here, amide hydrogen/deuterium exchange mass spectrometry has been applied to track changes in S dynamics from multiple SARS-CoV-2 variants. O...
Main Authors: | Sean M Braet, Theresa SC Buckley, Varun Venkatakrishnan, Kim-Marie A Dam, Pamela J Bjorkman, Ganesh S Anand |
---|---|
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2023-03-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/82584 |
Similar Items
-
Dynamic allostery in substrate binding by human thymidylate synthase
by: Jeffrey P Bonin, et al.
Published: (2022-10-01) -
Impaired cAMP processivity by phosphodiesterase-protein kinase A complexes in acrodysostosis
by: Varun Venkatakrishnan, et al.
Published: (2023-09-01) -
Interplay of disordered and ordered regions of a human small heat shock protein yields an ensemble of ‘quasi-ordered’ states
by: Amanda F Clouser, et al.
Published: (2019-10-01) -
A mutation uncouples the tubulin conformational and GTPase cycles, revealing allosteric control of microtubule dynamics
by: Elisabeth A Geyer, et al.
Published: (2015-10-01) -
Cyclic nucleotide binding and structural changes in the isolated GAF domain of Anabaena adenylyl cyclase, CyaB2
by: Kabir Hassan Biswas, et al.
Published: (2015-04-01)