Altered transfer of momentary mental states (ATOMS) as the basic unit of psychosis liability in interaction with environment and emotions.
Psychotic disorders are thought to represent altered neural function. However, research has failed to map diagnostic categories to alterations in neural networks. It is proposed that the basic unit of psychotic psychopathology is the moment-to-moment expression of subtle anomalous experiences of sub...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23457452/?tool=EBI |
| _version_ | 1828976139467489280 |
|---|---|
| author | Johanna T W Wigman Dina Collip Marieke Wichers Philippe Delespaul Catherine Derom Evert Thiery Wilma A M Vollebergh Tineke Lataster Nele Jacobs Inez Myin-Germeys Jim van Os |
| author_facet | Johanna T W Wigman Dina Collip Marieke Wichers Philippe Delespaul Catherine Derom Evert Thiery Wilma A M Vollebergh Tineke Lataster Nele Jacobs Inez Myin-Germeys Jim van Os |
| author_sort | Johanna T W Wigman |
| collection | DOAJ |
| description | Psychotic disorders are thought to represent altered neural function. However, research has failed to map diagnostic categories to alterations in neural networks. It is proposed that the basic unit of psychotic psychopathology is the moment-to-moment expression of subtle anomalous experiences of subclinical psychosis, and particularly its tendency to persist from moment-to-moment in daily life, under the influence of familial, environmental, emotional and cognitive factors.In a general population twin sample (n = 579) and in a study of patients with psychotic disorder (n = 57), their non-psychotic siblings (n = 59) and unrelated controls (n = 75), the experience sampling paradigm (ESM; repetitive, random sampling of momentary mental states and context) was applied. We analysed, in a within-person prospective design, (i) transfer of momentary anomalous experience at time point (t-1) to time point (t) in daily life, and (ii) moderating effects of negative affect, positive affect, daily stressors, IQ and childhood trauma. Additionally, (iii) familial associations between persistence of momentary anomalous experience and psychotic symptomatology were investigated. Higher level of schizotypy in the twins (but not higher level of psychotic symptoms in patients) predicted more persistence of momentary anomalous experience in daily life, both within subjects and across relatives. Persistence of momentary anomalous experience was highest in patients, intermediate in their siblings and lowest in controls. In both studies, persistence of momentary anomalous experience was moderated by higher levels of negative affect, daily stressors and childhood trauma (only in twins), and by lower levels of positive affect. The study of alterations in the moment-to-moment transfer of subtle anomalous experience of psychosis, resulting in their persistence, helps to explain why psychotic and emotional dysregulation tend to cluster in a single phenotype such as schizophrenia, and how familial and environmental risks increase the risk of expression of psychosis from, first, subtle momentary anomalous experience to, second, observable clinical symptoms. |
| first_indexed | 2024-12-14T14:31:21Z |
| format | Article |
| id | doaj.art-e1334c6a019f4c658e772d9e445a4aef |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T14:31:21Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-e1334c6a019f4c658e772d9e445a4aef2022-12-21T22:57:47ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0182e5465310.1371/journal.pone.0054653Altered transfer of momentary mental states (ATOMS) as the basic unit of psychosis liability in interaction with environment and emotions.Johanna T W WigmanDina CollipMarieke WichersPhilippe DelespaulCatherine DeromEvert ThieryWilma A M VolleberghTineke LatasterNele JacobsInez Myin-GermeysJim van OsPsychotic disorders are thought to represent altered neural function. However, research has failed to map diagnostic categories to alterations in neural networks. It is proposed that the basic unit of psychotic psychopathology is the moment-to-moment expression of subtle anomalous experiences of subclinical psychosis, and particularly its tendency to persist from moment-to-moment in daily life, under the influence of familial, environmental, emotional and cognitive factors.In a general population twin sample (n = 579) and in a study of patients with psychotic disorder (n = 57), their non-psychotic siblings (n = 59) and unrelated controls (n = 75), the experience sampling paradigm (ESM; repetitive, random sampling of momentary mental states and context) was applied. We analysed, in a within-person prospective design, (i) transfer of momentary anomalous experience at time point (t-1) to time point (t) in daily life, and (ii) moderating effects of negative affect, positive affect, daily stressors, IQ and childhood trauma. Additionally, (iii) familial associations between persistence of momentary anomalous experience and psychotic symptomatology were investigated. Higher level of schizotypy in the twins (but not higher level of psychotic symptoms in patients) predicted more persistence of momentary anomalous experience in daily life, both within subjects and across relatives. Persistence of momentary anomalous experience was highest in patients, intermediate in their siblings and lowest in controls. In both studies, persistence of momentary anomalous experience was moderated by higher levels of negative affect, daily stressors and childhood trauma (only in twins), and by lower levels of positive affect. The study of alterations in the moment-to-moment transfer of subtle anomalous experience of psychosis, resulting in their persistence, helps to explain why psychotic and emotional dysregulation tend to cluster in a single phenotype such as schizophrenia, and how familial and environmental risks increase the risk of expression of psychosis from, first, subtle momentary anomalous experience to, second, observable clinical symptoms.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23457452/?tool=EBI |
| spellingShingle | Johanna T W Wigman Dina Collip Marieke Wichers Philippe Delespaul Catherine Derom Evert Thiery Wilma A M Vollebergh Tineke Lataster Nele Jacobs Inez Myin-Germeys Jim van Os Altered transfer of momentary mental states (ATOMS) as the basic unit of psychosis liability in interaction with environment and emotions. PLoS ONE |
| title | Altered transfer of momentary mental states (ATOMS) as the basic unit of psychosis liability in interaction with environment and emotions. |
| title_full | Altered transfer of momentary mental states (ATOMS) as the basic unit of psychosis liability in interaction with environment and emotions. |
| title_fullStr | Altered transfer of momentary mental states (ATOMS) as the basic unit of psychosis liability in interaction with environment and emotions. |
| title_full_unstemmed | Altered transfer of momentary mental states (ATOMS) as the basic unit of psychosis liability in interaction with environment and emotions. |
| title_short | Altered transfer of momentary mental states (ATOMS) as the basic unit of psychosis liability in interaction with environment and emotions. |
| title_sort | altered transfer of momentary mental states atoms as the basic unit of psychosis liability in interaction with environment and emotions |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23457452/?tool=EBI |
| work_keys_str_mv | AT johannatwwigman alteredtransferofmomentarymentalstatesatomsasthebasicunitofpsychosisliabilityininteractionwithenvironmentandemotions AT dinacollip alteredtransferofmomentarymentalstatesatomsasthebasicunitofpsychosisliabilityininteractionwithenvironmentandemotions AT mariekewichers alteredtransferofmomentarymentalstatesatomsasthebasicunitofpsychosisliabilityininteractionwithenvironmentandemotions AT philippedelespaul alteredtransferofmomentarymentalstatesatomsasthebasicunitofpsychosisliabilityininteractionwithenvironmentandemotions AT catherinederom alteredtransferofmomentarymentalstatesatomsasthebasicunitofpsychosisliabilityininteractionwithenvironmentandemotions AT evertthiery alteredtransferofmomentarymentalstatesatomsasthebasicunitofpsychosisliabilityininteractionwithenvironmentandemotions AT wilmaamvollebergh alteredtransferofmomentarymentalstatesatomsasthebasicunitofpsychosisliabilityininteractionwithenvironmentandemotions AT tinekelataster alteredtransferofmomentarymentalstatesatomsasthebasicunitofpsychosisliabilityininteractionwithenvironmentandemotions AT nelejacobs alteredtransferofmomentarymentalstatesatomsasthebasicunitofpsychosisliabilityininteractionwithenvironmentandemotions AT inezmyingermeys alteredtransferofmomentarymentalstatesatomsasthebasicunitofpsychosisliabilityininteractionwithenvironmentandemotions AT jimvanos alteredtransferofmomentarymentalstatesatomsasthebasicunitofpsychosisliabilityininteractionwithenvironmentandemotions |