Management of anticoagulation with vitamin K antagonists in a tertiary hospital outpatient clinic
Introduction: atrial fibrillation (AF) is one of the main risk factors for stroke. Vitamin K antagonists (VKA) reduce this risk, and the effectiveness of this treatment is directly related to time in therapeutic range (TTR). This study aimed to report the TTR in patients with non-valvular AF at an a...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Hospital de Clinicas de Porto Alegre ; Universidade Federal do Rio Grande do Sul (UFRGS)
2014-06-01
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| Series: | Clinical and Biomedical Research |
| Subjects: | |
| Online Access: | http://seer.ufrgs.br/hcpa/article/view/44802 |
| _version_ | 1818130770342969344 |
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| author | Fernando Pivatto Júnior André Luis Ferreira da Silva Bárbara Bárbara Marina Simionato Fernanda Fuzinatto Jerônimo De Conto Oliveira Leonardo Martins Pires Roberta Cristina Petry Rafael Selbach Scheffel Luís Carlos Amon |
| author_facet | Fernando Pivatto Júnior André Luis Ferreira da Silva Bárbara Bárbara Marina Simionato Fernanda Fuzinatto Jerônimo De Conto Oliveira Leonardo Martins Pires Roberta Cristina Petry Rafael Selbach Scheffel Luís Carlos Amon |
| author_sort | Fernando Pivatto Júnior |
| collection | DOAJ |
| description | Introduction: atrial fibrillation (AF) is one of the main risk factors for stroke. Vitamin K antagonists (VKA) reduce this risk, and the effectiveness of this treatment is directly related to time in therapeutic range (TTR). This study aimed to report the TTR in patients with non-valvular AF at an anticoagulation outpatient clinic; and to describe the profile of this population of patients in terms of risk of stroke, as well as the occurrence of adverse events during the follow-up.
Methods: Retrospective cohort study involving patients of the anticoagulation outpatient clinic of the Department of Internal Medicine at Hospital de Clínicas de Porto Alegre. We evaluated outpatient visits, hospital admissions, and emergency visits from January to December 2011. TTR was calculated using the Rosendaal method.
Results: Sixty-three patients were investigated. Their mean age was 74.3±10.9 years. The CHADS2 score was ≥ 4 in 44.5% of the patients; 63.5% of them had a CHA2DS2-VASc score ≥ 5. The TTR was 64.8%. During follow-up, the incidence of overall bleeding was 31.7%, with major and minor bleeding rates of 4.8% and 34.9%, respectively. There were no other complications related to AF or anticoagulation.
Conclusion: The patients achieved a TTR of 64.8% during follow-up, which is deemed appropriate and in agreement with the literature. Patients had high risk for stroke, and the incidence of minor bleeding was higher than the rate found in the literature, whereas the incidence of major bleeding was similar to the one found in previous studies. |
| first_indexed | 2024-12-11T08:10:19Z |
| format | Article |
| id | doaj.art-e134a062b00945b2acedd8a2fac54c4d |
| institution | Directory Open Access Journal |
| issn | 0101-5575 2357-9730 |
| language | English |
| last_indexed | 2024-12-11T08:10:19Z |
| publishDate | 2014-06-01 |
| publisher | Hospital de Clinicas de Porto Alegre ; Universidade Federal do Rio Grande do Sul (UFRGS) |
| record_format | Article |
| series | Clinical and Biomedical Research |
| spelling | doaj.art-e134a062b00945b2acedd8a2fac54c4d2022-12-22T01:14:55ZengHospital de Clinicas de Porto Alegre ; Universidade Federal do Rio Grande do Sul (UFRGS)Clinical and Biomedical Research0101-55752357-97302014-06-0134224385Management of anticoagulation with vitamin K antagonists in a tertiary hospital outpatient clinicFernando Pivatto JúniorAndré Luis Ferreira da SilvaBárbara Bárbara Marina SimionatoFernanda FuzinattoJerônimo De Conto OliveiraLeonardo Martins PiresRoberta Cristina PetryRafael Selbach ScheffelLuís Carlos AmonIntroduction: atrial fibrillation (AF) is one of the main risk factors for stroke. Vitamin K antagonists (VKA) reduce this risk, and the effectiveness of this treatment is directly related to time in therapeutic range (TTR). This study aimed to report the TTR in patients with non-valvular AF at an anticoagulation outpatient clinic; and to describe the profile of this population of patients in terms of risk of stroke, as well as the occurrence of adverse events during the follow-up. Methods: Retrospective cohort study involving patients of the anticoagulation outpatient clinic of the Department of Internal Medicine at Hospital de Clínicas de Porto Alegre. We evaluated outpatient visits, hospital admissions, and emergency visits from January to December 2011. TTR was calculated using the Rosendaal method. Results: Sixty-three patients were investigated. Their mean age was 74.3±10.9 years. The CHADS2 score was ≥ 4 in 44.5% of the patients; 63.5% of them had a CHA2DS2-VASc score ≥ 5. The TTR was 64.8%. During follow-up, the incidence of overall bleeding was 31.7%, with major and minor bleeding rates of 4.8% and 34.9%, respectively. There were no other complications related to AF or anticoagulation. Conclusion: The patients achieved a TTR of 64.8% during follow-up, which is deemed appropriate and in agreement with the literature. Patients had high risk for stroke, and the incidence of minor bleeding was higher than the rate found in the literature, whereas the incidence of major bleeding was similar to the one found in previous studies.http://seer.ufrgs.br/hcpa/article/view/44802Anticoagulantswarfarinphenprocoumonatrial fibrillationinternship and residency |
| spellingShingle | Fernando Pivatto Júnior André Luis Ferreira da Silva Bárbara Bárbara Marina Simionato Fernanda Fuzinatto Jerônimo De Conto Oliveira Leonardo Martins Pires Roberta Cristina Petry Rafael Selbach Scheffel Luís Carlos Amon Management of anticoagulation with vitamin K antagonists in a tertiary hospital outpatient clinic Clinical and Biomedical Research Anticoagulants warfarin phenprocoumon atrial fibrillation internship and residency |
| title | Management of anticoagulation with vitamin K antagonists in a tertiary hospital outpatient clinic |
| title_full | Management of anticoagulation with vitamin K antagonists in a tertiary hospital outpatient clinic |
| title_fullStr | Management of anticoagulation with vitamin K antagonists in a tertiary hospital outpatient clinic |
| title_full_unstemmed | Management of anticoagulation with vitamin K antagonists in a tertiary hospital outpatient clinic |
| title_short | Management of anticoagulation with vitamin K antagonists in a tertiary hospital outpatient clinic |
| title_sort | management of anticoagulation with vitamin k antagonists in a tertiary hospital outpatient clinic |
| topic | Anticoagulants warfarin phenprocoumon atrial fibrillation internship and residency |
| url | http://seer.ufrgs.br/hcpa/article/view/44802 |
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