Three-Dimensional Analysis of Sex- and Gonadal Status- Dependent Microglial Activation in a Mouse Model of Parkinson’s Disease

Three-Dimensional Analysis of Sex- and Gonadal Status- Dependent Microglial Activation in a Mouse Model of Parkinson’s Disease

Parkinson’s disease (PD) is characterized by neurodegeneration and neuroinflammation. PD prevalence and incidence are higher in men than in women and modulation of gonadal hormones could have an impact on the disease course. This was investigated in male and female gonadectomized (GDX) and SHAM oper...

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Bibliographic Details
Main Authors: Amandine Isenbrandt, Katherine Coulombe, Marc Morissette, Mélanie Bourque, Jérôme Lamontagne-Proulx, Thérèse Di Paolo, Denis Soulet
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Pharmaceuticals
Subjects:
Parkinson’s disease
sex differences
microglial activation
microglial morphology
dutasteride
Online Access:https://www.mdpi.com/1424-8247/16/2/152

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