Differences in EEG Event-Related Potentials during Dual Task in Parkinson’s Disease Carriers and Non-Carriers of the G2019S-LRRK2 Mutation
Background: The G2019S-<i>LRRK2</i> gene mutation is a common cause of hereditary Parkinson’s disease (PD), associated with a higher frequency of the postural instability gait difficulty (PIGD) motor phenotype yet with preserved cognition. This study investigated neurophysiological chang...
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MDPI AG
2023-10-01
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| Series: | Sensors |
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| Online Access: | https://www.mdpi.com/1424-8220/23/19/8266 |
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| author | Eden Shkury Shani Danziger-Schragenheim Zoya Katzir Yael Ezra Nir Giladi Anat Mirelman Inbal Maidan |
| author_facet | Eden Shkury Shani Danziger-Schragenheim Zoya Katzir Yael Ezra Nir Giladi Anat Mirelman Inbal Maidan |
| author_sort | Eden Shkury |
| collection | DOAJ |
| description | Background: The G2019S-<i>LRRK2</i> gene mutation is a common cause of hereditary Parkinson’s disease (PD), associated with a higher frequency of the postural instability gait difficulty (PIGD) motor phenotype yet with preserved cognition. This study investigated neurophysiological changes during motor and cognitive tasks in PD patients with and without the <i>G2019S-LRRK2</i> mutation. Methods: 33 iPD patients and 22 <i>LRRK2-PD</i> patients performed the visual Go/NoGo task (VGNG) during sitting (single-task) and walking (dual-task) while wearing a 64-channel EEG cap. Event-related potentials (ERP) from Fz and Pz, specifically N200 and P300, were extracted and analyzed to quantify brain activity patterns. Results: The <i>LRRK2-PD</i> group performed better in the VGNG than the iPD group (group*task; <i>p</i> = 0.05). During Go, the iPD group showed reduced N2 amplitude and prolonged N2 latency during walking, whereas the <i>LRRK2-PD</i> group showed only shorter latency (group*task <i>p</i> = 0.027). During NoGo, opposite patterns emerged; the iPD group showed reduced N2 and increased P3 amplitudes during walking while the <i>LRRK2-PD</i> group demonstrated increased N2 and reduced P3 (N2: group*task, <i>p</i> = 0.010, P3: group*task, <i>p</i> = 0.012). Conclusions: The <i>LRRK2-PD</i> group showed efficient early cognitive processes, reflected by N2, resulting in greater neural synchronization and prominent ERPs. These processes are possibly the underlying mechanisms for the observed better cognitive performance as compared to the iPD group. As such, future applications of intelligent medical sensing should be capable of capturing these electrophysiological patterns in order to enhance motor–cognitive functions. |
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| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-03-10T21:35:06Z |
| publishDate | 2023-10-01 |
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| spelling | doaj.art-e1378bb62dae4f5abf8f82d2331e42b72023-11-19T15:05:07ZengMDPI AGSensors1424-82202023-10-012319826610.3390/s23198266Differences in EEG Event-Related Potentials during Dual Task in Parkinson’s Disease Carriers and Non-Carriers of the G2019S-LRRK2 MutationEden Shkury0Shani Danziger-Schragenheim1Zoya Katzir2Yael Ezra3Nir Giladi4Anat Mirelman5Inbal Maidan6Laboratory of Early Markers of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, IsraelLaboratory of Early Markers of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, IsraelLaboratory of Early Markers of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, IsraelLaboratory of Early Markers of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, IsraelLaboratory of Early Markers of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, IsraelLaboratory of Early Markers of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, IsraelLaboratory of Early Markers of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, IsraelBackground: The G2019S-<i>LRRK2</i> gene mutation is a common cause of hereditary Parkinson’s disease (PD), associated with a higher frequency of the postural instability gait difficulty (PIGD) motor phenotype yet with preserved cognition. This study investigated neurophysiological changes during motor and cognitive tasks in PD patients with and without the <i>G2019S-LRRK2</i> mutation. Methods: 33 iPD patients and 22 <i>LRRK2-PD</i> patients performed the visual Go/NoGo task (VGNG) during sitting (single-task) and walking (dual-task) while wearing a 64-channel EEG cap. Event-related potentials (ERP) from Fz and Pz, specifically N200 and P300, were extracted and analyzed to quantify brain activity patterns. Results: The <i>LRRK2-PD</i> group performed better in the VGNG than the iPD group (group*task; <i>p</i> = 0.05). During Go, the iPD group showed reduced N2 amplitude and prolonged N2 latency during walking, whereas the <i>LRRK2-PD</i> group showed only shorter latency (group*task <i>p</i> = 0.027). During NoGo, opposite patterns emerged; the iPD group showed reduced N2 and increased P3 amplitudes during walking while the <i>LRRK2-PD</i> group demonstrated increased N2 and reduced P3 (N2: group*task, <i>p</i> = 0.010, P3: group*task, <i>p</i> = 0.012). Conclusions: The <i>LRRK2-PD</i> group showed efficient early cognitive processes, reflected by N2, resulting in greater neural synchronization and prominent ERPs. These processes are possibly the underlying mechanisms for the observed better cognitive performance as compared to the iPD group. As such, future applications of intelligent medical sensing should be capable of capturing these electrophysiological patterns in order to enhance motor–cognitive functions.https://www.mdpi.com/1424-8220/23/19/8266Parkinson’s diseasecognitionLRRK2electroencephalography (EEG)event-related potential (ERP) |
| spellingShingle | Eden Shkury Shani Danziger-Schragenheim Zoya Katzir Yael Ezra Nir Giladi Anat Mirelman Inbal Maidan Differences in EEG Event-Related Potentials during Dual Task in Parkinson’s Disease Carriers and Non-Carriers of the G2019S-LRRK2 Mutation Sensors Parkinson’s disease cognition LRRK2 electroencephalography (EEG) event-related potential (ERP) |
| title | Differences in EEG Event-Related Potentials during Dual Task in Parkinson’s Disease Carriers and Non-Carriers of the G2019S-LRRK2 Mutation |
| title_full | Differences in EEG Event-Related Potentials during Dual Task in Parkinson’s Disease Carriers and Non-Carriers of the G2019S-LRRK2 Mutation |
| title_fullStr | Differences in EEG Event-Related Potentials during Dual Task in Parkinson’s Disease Carriers and Non-Carriers of the G2019S-LRRK2 Mutation |
| title_full_unstemmed | Differences in EEG Event-Related Potentials during Dual Task in Parkinson’s Disease Carriers and Non-Carriers of the G2019S-LRRK2 Mutation |
| title_short | Differences in EEG Event-Related Potentials during Dual Task in Parkinson’s Disease Carriers and Non-Carriers of the G2019S-LRRK2 Mutation |
| title_sort | differences in eeg event related potentials during dual task in parkinson s disease carriers and non carriers of the g2019s lrrk2 mutation |
| topic | Parkinson’s disease cognition LRRK2 electroencephalography (EEG) event-related potential (ERP) |
| url | https://www.mdpi.com/1424-8220/23/19/8266 |
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