Preservation of myocardial contractility during acute hypoxia with OMX-CV, a novel oxygen delivery biotherapeutic.

Preservation of myocardial contractility during acute hypoxia with OMX-CV, a novel oxygen delivery biotherapeutic.

The heart exhibits the highest basal oxygen (O2) consumption per tissue mass of any organ in the body and is uniquely dependent on aerobic metabolism to sustain contractile function. During acute hypoxic states, the body responds with a compensatory increase in cardiac output that further increases...

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Bibliographic Details
Main Authors: Jason Boehme, Natacha Le Moan, Rebecca J Kameny, Alexandra Loucks, Michael J Johengen, Amy L Lesneski, Wenhui Gong, Brian D. Goudy, Tina Davis, Kevin Tanaka, Andrew Davis, Youping He, Janel Long-Boyle, Vijay Ivaturi, Jogarao V S Gobburu, Jonathan A Winger, Stephen P Cary, Sanjeev A Datar, Jeffrey R Fineman, Ana Krtolica, Emin Maltepe
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-10-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC6193608?pdf=render

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