Assessment of hepatic steatosis of potential living donor before liver transplantation using liver/spleen CT attenuation ratio compared to liver biopsy
Abstract Background Hepatic steatosis has become a major worldwide health problem, so assessment of hepatic steatosis in potential living donors is crucial prior to liver transplantation. Until now liver biopsy (LB) is considered the gold standard for diagnosing steatosis before transplantation, how...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-12-01
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| Series: | The Egyptian Journal of Radiology and Nuclear Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43055-023-01165-z |
| _version_ | 1797398108182675456 |
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| author | Hesham Mohamed Atef Enas Mohamed Korayem Naglaa Allam Ahmed Mohamed Mohamed Houseni Ahmed Mohamed El-Refaie Manal Ibrahim Gomaa |
| author_facet | Hesham Mohamed Atef Enas Mohamed Korayem Naglaa Allam Ahmed Mohamed Mohamed Houseni Ahmed Mohamed El-Refaie Manal Ibrahim Gomaa |
| author_sort | Hesham Mohamed Atef |
| collection | DOAJ |
| description | Abstract Background Hepatic steatosis has become a major worldwide health problem, so assessment of hepatic steatosis in potential living donors is crucial prior to liver transplantation. Until now liver biopsy (LB) is considered the gold standard for diagnosing steatosis before transplantation, however steatosis assessment using imaging modalities, such as computerized tomography (CT), would be better for the donor, due its non-invasiveness. This study aimed to assess the efficacy of CT as a semiquantitaive tool for liver steatosis assessment in liver donors in comparison to liver biopsy results. Methods This cross-sectional study was carried out on 53 potential liver graft donors. All patients were subjected to non-contrast CT of the abdomen, tru-cut liver biopsy, and histopathological evaluation. The CT liver attenuation (CTL), the hepatic/splenic CT attenuation ratio (CTL/S) and difference between hepatic attenuation value and splenic attenuation values (CTL–S) were determined as well as the correlations of these indices and the findings of Liver biopsy (LB) were compared. Results According to the hepatosteatosis grades in the pathology results, the patients were divided into two groups: group A: 38 patients with grade 0 hepatosteatosis and group B: 15 patients with grade 1 and 2 hepatosteatosis. CTL, CTL–S, CTL/S, ratio of mean right hepatic lobe and splenic attenuation (RT/S) and ratio of mean left hepatic lobe and splenic attenuation (LT/S) were found to be effective in the diagnosis of hepatosteatosis grades at cutoff values ≤ 55.4, ≤ 8.7, ≤ 1.17, ≤ 1.1548 and ≤ 1.2971 with 80%, 80%, 73.3%, 86.7% and 86.7% sensitivity and 71.1%, 56.8%, 73.7% 71.1% and 50.0% specificity respectively. Also, CTL/S was found to be very effective in the diagnosis of grade II hepatosteatosis at cutoff values ≤ 0.9 with 100% sensitivity and 100% specificity. There was significant negative correlations between the CT indexes and degree of hepatosteatosis. Conclusions Compared to biopsy results, CT noninvasive indices strongly predicted the presence of hepatosteatosis, which can help in avoiding the necessity for this invasive technique. |
| first_indexed | 2024-03-09T01:20:55Z |
| format | Article |
| id | doaj.art-e13ca4d8610c46c0981f2c6fde54a184 |
| institution | Directory Open Access Journal |
| issn | 2090-4762 |
| language | English |
| last_indexed | 2024-03-09T01:20:55Z |
| publishDate | 2023-12-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Radiology and Nuclear Medicine |
| spelling | doaj.art-e13ca4d8610c46c0981f2c6fde54a1842023-12-10T12:11:51ZengSpringerOpenThe Egyptian Journal of Radiology and Nuclear Medicine2090-47622023-12-015411910.1186/s43055-023-01165-zAssessment of hepatic steatosis of potential living donor before liver transplantation using liver/spleen CT attenuation ratio compared to liver biopsyHesham Mohamed Atef0Enas Mohamed Korayem1Naglaa Allam Ahmed2Mohamed Mohamed Houseni3Ahmed Mohamed El-Refaie4Manal Ibrahim Gomaa5National Liver Institute, Menoufia UniversityNational Liver Institute, Menoufia UniversityNational Liver Institute, Menoufia UniversityNational Liver Institute, Menoufia UniversityNational Liver Institute, Menoufia UniversityNational Liver Institute, Menoufia UniversityAbstract Background Hepatic steatosis has become a major worldwide health problem, so assessment of hepatic steatosis in potential living donors is crucial prior to liver transplantation. Until now liver biopsy (LB) is considered the gold standard for diagnosing steatosis before transplantation, however steatosis assessment using imaging modalities, such as computerized tomography (CT), would be better for the donor, due its non-invasiveness. This study aimed to assess the efficacy of CT as a semiquantitaive tool for liver steatosis assessment in liver donors in comparison to liver biopsy results. Methods This cross-sectional study was carried out on 53 potential liver graft donors. All patients were subjected to non-contrast CT of the abdomen, tru-cut liver biopsy, and histopathological evaluation. The CT liver attenuation (CTL), the hepatic/splenic CT attenuation ratio (CTL/S) and difference between hepatic attenuation value and splenic attenuation values (CTL–S) were determined as well as the correlations of these indices and the findings of Liver biopsy (LB) were compared. Results According to the hepatosteatosis grades in the pathology results, the patients were divided into two groups: group A: 38 patients with grade 0 hepatosteatosis and group B: 15 patients with grade 1 and 2 hepatosteatosis. CTL, CTL–S, CTL/S, ratio of mean right hepatic lobe and splenic attenuation (RT/S) and ratio of mean left hepatic lobe and splenic attenuation (LT/S) were found to be effective in the diagnosis of hepatosteatosis grades at cutoff values ≤ 55.4, ≤ 8.7, ≤ 1.17, ≤ 1.1548 and ≤ 1.2971 with 80%, 80%, 73.3%, 86.7% and 86.7% sensitivity and 71.1%, 56.8%, 73.7% 71.1% and 50.0% specificity respectively. Also, CTL/S was found to be very effective in the diagnosis of grade II hepatosteatosis at cutoff values ≤ 0.9 with 100% sensitivity and 100% specificity. There was significant negative correlations between the CT indexes and degree of hepatosteatosis. Conclusions Compared to biopsy results, CT noninvasive indices strongly predicted the presence of hepatosteatosis, which can help in avoiding the necessity for this invasive technique.https://doi.org/10.1186/s43055-023-01165-zHepatic steatosisLiver transplantationCT IndicesLiver biopsy |
| spellingShingle | Hesham Mohamed Atef Enas Mohamed Korayem Naglaa Allam Ahmed Mohamed Mohamed Houseni Ahmed Mohamed El-Refaie Manal Ibrahim Gomaa Assessment of hepatic steatosis of potential living donor before liver transplantation using liver/spleen CT attenuation ratio compared to liver biopsy The Egyptian Journal of Radiology and Nuclear Medicine Hepatic steatosis Liver transplantation CT Indices Liver biopsy |
| title | Assessment of hepatic steatosis of potential living donor before liver transplantation using liver/spleen CT attenuation ratio compared to liver biopsy |
| title_full | Assessment of hepatic steatosis of potential living donor before liver transplantation using liver/spleen CT attenuation ratio compared to liver biopsy |
| title_fullStr | Assessment of hepatic steatosis of potential living donor before liver transplantation using liver/spleen CT attenuation ratio compared to liver biopsy |
| title_full_unstemmed | Assessment of hepatic steatosis of potential living donor before liver transplantation using liver/spleen CT attenuation ratio compared to liver biopsy |
| title_short | Assessment of hepatic steatosis of potential living donor before liver transplantation using liver/spleen CT attenuation ratio compared to liver biopsy |
| title_sort | assessment of hepatic steatosis of potential living donor before liver transplantation using liver spleen ct attenuation ratio compared to liver biopsy |
| topic | Hepatic steatosis Liver transplantation CT Indices Liver biopsy |
| url | https://doi.org/10.1186/s43055-023-01165-z |
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