Association Abnormal Levels of Serum Interleukin-33, Interleukin-23 with Oxidant-Antioxidants Status in patients with Acute Liver Failure
Acute liver failure (ALF) is not itself a disease, but a condition that develops rapidly in response to some forms of liver injury. There is no evidence to prove an association between serum IL-33 with oxidant- antioxidant status in patients of liver failure. The present study aimed to evaluate the...
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| Format: | Article |
| Language: | English |
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University of Thi-Qar
2022-12-01
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| Series: | مجلة علوم ذي قار |
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| Online Access: | https://jsci.utq.edu.iq/index.php/main/article/view/911 |
| _version_ | 1827766095142977536 |
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| author | Auhood k. zaid Sarah A Sayer |
| author_facet | Auhood k. zaid Sarah A Sayer |
| author_sort | Auhood k. zaid |
| collection | DOAJ |
| description |
Acute liver failure (ALF) is not itself a disease, but a condition that develops rapidly in response to some forms of liver injury. There is no evidence to prove an association between serum IL-33 with oxidant- antioxidant status in patients of liver failure. The present study aimed to evaluate the possible association between these parameters and to investigation the prognostic role of interleukin-33 in liver failure disease by using the ROC curve. This study includes (30 patients and 30 controls ((were 17 men and 13 female)). During the period of 2021- 2022, patients and controls aged 30- 55 years. The results showed that there is a significant increase in the serum levels of ( MDA, NO, CP , IL-33 and IL-23) in patients group in comparison with controls group Furthermore, it was found that there is a positive correlation between IL-33 and ( IL-23, MDA, NO and Cp ).The ROC curve demonstrated that the levels of (IL-33, IL-23, MDA, NO and CP) have exhibited an good method for discriminating’ between healthy individuals and patients with acute liver failure .In Conclusion, our findings indicated that there is an association between abnormal serum IL-33 levels and Oxidant-Antioxidants Status. Moreover, the level of IL-33 can consider an early prediction biomarker for gestational diabetes. The use of ROC curve analysis confirmed thatIL-33 is effective for the diagnosis of liver failure.
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| first_indexed | 2024-03-11T11:38:03Z |
| format | Article |
| id | doaj.art-e13cab941a1b445b9811a71a04925f22 |
| institution | Directory Open Access Journal |
| issn | 1991-8690 2709-0256 |
| language | English |
| last_indexed | 2024-03-11T11:38:03Z |
| publishDate | 2022-12-01 |
| publisher | University of Thi-Qar |
| record_format | Article |
| series | مجلة علوم ذي قار |
| spelling | doaj.art-e13cab941a1b445b9811a71a04925f222023-11-10T13:13:39ZengUniversity of Thi-Qarمجلة علوم ذي قار1991-86902709-02562022-12-019210.32792/utq/utjsci/v9i2.911Association Abnormal Levels of Serum Interleukin-33, Interleukin-23 with Oxidant-Antioxidants Status in patients with Acute Liver FailureAuhood k. zaidSarah A Sayer Acute liver failure (ALF) is not itself a disease, but a condition that develops rapidly in response to some forms of liver injury. There is no evidence to prove an association between serum IL-33 with oxidant- antioxidant status in patients of liver failure. The present study aimed to evaluate the possible association between these parameters and to investigation the prognostic role of interleukin-33 in liver failure disease by using the ROC curve. This study includes (30 patients and 30 controls ((were 17 men and 13 female)). During the period of 2021- 2022, patients and controls aged 30- 55 years. The results showed that there is a significant increase in the serum levels of ( MDA, NO, CP , IL-33 and IL-23) in patients group in comparison with controls group Furthermore, it was found that there is a positive correlation between IL-33 and ( IL-23, MDA, NO and Cp ).The ROC curve demonstrated that the levels of (IL-33, IL-23, MDA, NO and CP) have exhibited an good method for discriminating’ between healthy individuals and patients with acute liver failure .In Conclusion, our findings indicated that there is an association between abnormal serum IL-33 levels and Oxidant-Antioxidants Status. Moreover, the level of IL-33 can consider an early prediction biomarker for gestational diabetes. The use of ROC curve analysis confirmed thatIL-33 is effective for the diagnosis of liver failure. https://jsci.utq.edu.iq/index.php/main/article/view/911Acute Liver Failure, IL-33, IL-23, Oxidant-Antioxidants Status. |
| spellingShingle | Auhood k. zaid Sarah A Sayer Association Abnormal Levels of Serum Interleukin-33, Interleukin-23 with Oxidant-Antioxidants Status in patients with Acute Liver Failure مجلة علوم ذي قار Acute Liver Failure, IL-33, IL-23, Oxidant-Antioxidants Status. |
| title | Association Abnormal Levels of Serum Interleukin-33, Interleukin-23 with Oxidant-Antioxidants Status in patients with Acute Liver Failure |
| title_full | Association Abnormal Levels of Serum Interleukin-33, Interleukin-23 with Oxidant-Antioxidants Status in patients with Acute Liver Failure |
| title_fullStr | Association Abnormal Levels of Serum Interleukin-33, Interleukin-23 with Oxidant-Antioxidants Status in patients with Acute Liver Failure |
| title_full_unstemmed | Association Abnormal Levels of Serum Interleukin-33, Interleukin-23 with Oxidant-Antioxidants Status in patients with Acute Liver Failure |
| title_short | Association Abnormal Levels of Serum Interleukin-33, Interleukin-23 with Oxidant-Antioxidants Status in patients with Acute Liver Failure |
| title_sort | association abnormal levels of serum interleukin 33 interleukin 23 with oxidant antioxidants status in patients with acute liver failure |
| topic | Acute Liver Failure, IL-33, IL-23, Oxidant-Antioxidants Status. |
| url | https://jsci.utq.edu.iq/index.php/main/article/view/911 |
| work_keys_str_mv | AT auhoodkzaid associationabnormallevelsofseruminterleukin33interleukin23withoxidantantioxidantsstatusinpatientswithacuteliverfailure AT sarahasayer associationabnormallevelsofseruminterleukin33interleukin23withoxidantantioxidantsstatusinpatientswithacuteliverfailure |