An E2F1-mediated DNA damage response contributes to the replication of human cytomegalovirus.

An E2F1-mediated DNA damage response contributes to the replication of human cytomegalovirus.

DNA damage resulting from intrinsic or extrinsic sources activates DNA damage responses (DDRs) centered on protein kinase signaling cascades. The usual consequences of inducing DDRs include the activation of cell cycle checkpoints together with repair of the damaged DNA or induction of apoptosis. Ma...

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Bibliographic Details
Main Authors: Xiaofei E, Mary T Pickering, Michelle Debatis, Jonathan Castillo, Alexander Lagadinos, Shixia Wang, Shan Lu, Timothy F Kowalik
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-05-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3093362?pdf=render

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