Incidence and attributable costs of ventilator-associated pneumonia (VAP) in a tertiary-level intensive care unit (ICU) in northern India
Background: Ventilator-associated pneumonia (VAP) is the most common nosocomial infection acquired by patients in the intensive care unit (ICU). However, the economic effects of such infections remain unclear particularly in developing countries. Methods: Patients who were mechanically ventilated fo...
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| Format: | Article |
| Language: | English |
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Elsevier
2015-03-01
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| Series: | Journal of Infection and Public Health |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1876034114001051 |
| _version_ | 1819237946683817984 |
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| author | Ashu Sara Mathai Atul Phillips Paramdeep Kaur Rajesh Isaac |
| author_facet | Ashu Sara Mathai Atul Phillips Paramdeep Kaur Rajesh Isaac |
| author_sort | Ashu Sara Mathai |
| collection | DOAJ |
| description | Background: Ventilator-associated pneumonia (VAP) is the most common nosocomial infection acquired by patients in the intensive care unit (ICU). However, the economic effects of such infections remain unclear particularly in developing countries. Methods: Patients who were mechanically ventilated for more than 48 h in the ICU were studied for the occurrence of VAP. Total drug costs and hospital costs were noted, and attributable costs were calculated after adjusting for potential confounders. Results: Ninety-five (38%) patients who were ventilated for more than 48 h developed VAP, which resulted in an incidence of 40.1 VAP infections/1000 mechanical ventilation days. The patients with VAP experienced significantly longer hospital stay [21 (IQ = 14–33) days versus 11 (IQ = 6–18) days, P < 0.0001)] and incurred greater hospital costs [USD $6250.92 (IQ = 3525.39–9667.57) versus $2598.84 (IQ = 1644.33–4477.65), P < 0.0001]. Multiple regression analysis revealed that the cost-driving factors in our study population were the occurrence of VAP infections (P < 0.0001) and the duration of hospital stay (P < 0.0001). The attributable cost of VAP infection was calculated to be USD $5200 (95% CI = 3245–7152). Conclusion: We conclude that VAP significantly increases the costs of treatment in low-income developing countries. This study highlights the need to implement urgent measures to reduce the incidence of this disease in ICUs. Keywords: Ventilator-associated pneumonia, Attributable costs, Intensive care unit |
| first_indexed | 2024-12-23T13:28:25Z |
| format | Article |
| id | doaj.art-e1419801dcb94e2387d0d497fbfcc3ee |
| institution | Directory Open Access Journal |
| issn | 1876-0341 |
| language | English |
| last_indexed | 2024-12-23T13:28:25Z |
| publishDate | 2015-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Infection and Public Health |
| spelling | doaj.art-e1419801dcb94e2387d0d497fbfcc3ee2022-12-21T17:45:15ZengElsevierJournal of Infection and Public Health1876-03412015-03-0182127135Incidence and attributable costs of ventilator-associated pneumonia (VAP) in a tertiary-level intensive care unit (ICU) in northern IndiaAshu Sara Mathai0Atul Phillips1Paramdeep Kaur2Rajesh Isaac3Department of Anaesthesiology and Critical Care, Christian Medical College, Ludhiana 141008, Punjab, India; Corresponding author. Tel.: +91 9888500240/161 2226506; fax: +91 161 5050599.Department of Anaesthesiology and Critical Care, Christian Medical College, Ludhiana 141008, Punjab, IndiaDepartment of Community Medicine, Christian Medical College, Ludhiana 141008, Punjab, IndiaDepartment of Community Medicine, Christian Medical College, Ludhiana 141008, Punjab, IndiaBackground: Ventilator-associated pneumonia (VAP) is the most common nosocomial infection acquired by patients in the intensive care unit (ICU). However, the economic effects of such infections remain unclear particularly in developing countries. Methods: Patients who were mechanically ventilated for more than 48 h in the ICU were studied for the occurrence of VAP. Total drug costs and hospital costs were noted, and attributable costs were calculated after adjusting for potential confounders. Results: Ninety-five (38%) patients who were ventilated for more than 48 h developed VAP, which resulted in an incidence of 40.1 VAP infections/1000 mechanical ventilation days. The patients with VAP experienced significantly longer hospital stay [21 (IQ = 14–33) days versus 11 (IQ = 6–18) days, P < 0.0001)] and incurred greater hospital costs [USD $6250.92 (IQ = 3525.39–9667.57) versus $2598.84 (IQ = 1644.33–4477.65), P < 0.0001]. Multiple regression analysis revealed that the cost-driving factors in our study population were the occurrence of VAP infections (P < 0.0001) and the duration of hospital stay (P < 0.0001). The attributable cost of VAP infection was calculated to be USD $5200 (95% CI = 3245–7152). Conclusion: We conclude that VAP significantly increases the costs of treatment in low-income developing countries. This study highlights the need to implement urgent measures to reduce the incidence of this disease in ICUs. Keywords: Ventilator-associated pneumonia, Attributable costs, Intensive care unithttp://www.sciencedirect.com/science/article/pii/S1876034114001051 |
| spellingShingle | Ashu Sara Mathai Atul Phillips Paramdeep Kaur Rajesh Isaac Incidence and attributable costs of ventilator-associated pneumonia (VAP) in a tertiary-level intensive care unit (ICU) in northern India Journal of Infection and Public Health |
| title | Incidence and attributable costs of ventilator-associated pneumonia (VAP) in a tertiary-level intensive care unit (ICU) in northern India |
| title_full | Incidence and attributable costs of ventilator-associated pneumonia (VAP) in a tertiary-level intensive care unit (ICU) in northern India |
| title_fullStr | Incidence and attributable costs of ventilator-associated pneumonia (VAP) in a tertiary-level intensive care unit (ICU) in northern India |
| title_full_unstemmed | Incidence and attributable costs of ventilator-associated pneumonia (VAP) in a tertiary-level intensive care unit (ICU) in northern India |
| title_short | Incidence and attributable costs of ventilator-associated pneumonia (VAP) in a tertiary-level intensive care unit (ICU) in northern India |
| title_sort | incidence and attributable costs of ventilator associated pneumonia vap in a tertiary level intensive care unit icu in northern india |
| url | http://www.sciencedirect.com/science/article/pii/S1876034114001051 |
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