Angiogenesis in NENs, with a focus on gastroenteropancreatic NENs: from biology to current and future therapeutic implications

Angiogenesis in NENs, with a focus on gastroenteropancreatic NENs: from biology to current and future therapeutic implications

Neuroendocrine neoplasms (NENs) are highly vascularized malignancies arising from cells of the diffuse neuroendocrine system. An intricated cross-talk exists between NEN cells and the tumor microenvironment, and three main molecular circuits (VEGF/VEGFR pathway, FGF-dependent signaling and PDGF/PDGF...

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Bibliographic Details
Main Authors: Eleonora Lauricella, Barbara Mandriani, Federica Cavallo, Gaetano Pezzicoli, Nada Chaoul, Camillo Porta, Mauro Cives
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Oncology
Subjects:
cabozantinib
lenvatinib
pazopanib
carcinoid tumor
TKIs (tyrosine kinase inhibitors)
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.957068/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.957068/full

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