Gata3 Silencing Is Involved in Neuronal Differentiation and Its Abnormal Expression Impedes Neural Activity in Adult Retinal Neurocytes

Gata3 Silencing Is Involved in Neuronal Differentiation and Its Abnormal Expression Impedes Neural Activity in Adult Retinal Neurocytes

GATA binding protein 3 (Gata3), a zinc-finger transcription factor, plays an important role in neural development. However, its expression and bioactivity in the retina remain unclear. In the present study, our data indicated that Gata3 maintains the precursor state of 661W cells, and Gata3 silencin...

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Bibliographic Details
Main Authors: Pei Chen, Yihui Wu, Jiejie Zhuang, Xuan Liu, Qian Luo, Qiyun Wang, Zihua Jiang, Anqi He, Shuilian Chen, Xi Chen, Jin Qiu, Yan Li, Ying Yang, Keming Yu, Jing Zhuang
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:International Journal of Molecular Sciences
Subjects:
GATA binding protein 3
neuronal differentiation
retinal neurocytes
retina development
precursor cell
Online Access:https://www.mdpi.com/1422-0067/23/5/2495

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