In-host modeling
Understanding the mechanisms governing host-pathogen kinetics is important and can guide human interventions. In-host mathematical models, together with biological data, have been used in this endeavor. In this review, we present basic models used to describe acute and chronic pathogenic infections....
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2017-05-01
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| Series: | Infectious Disease Modelling |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468042717300039 |
| _version_ | 1797205324370804736 |
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| author | Stanca M. Ciupe Jane M. Heffernan |
| author_facet | Stanca M. Ciupe Jane M. Heffernan |
| author_sort | Stanca M. Ciupe |
| collection | DOAJ |
| description | Understanding the mechanisms governing host-pathogen kinetics is important and can guide human interventions. In-host mathematical models, together with biological data, have been used in this endeavor. In this review, we present basic models used to describe acute and chronic pathogenic infections. We highlight the power of model predictions, the role of drug therapy, and advantage of considering the dynamics of immune responses. We also present the limitations of these models due in part to the trade-off between the complexity of the model and their predictive power, and the challenges a modeler faces in determining the appropriate formulation for a given problem. |
| first_indexed | 2024-04-24T08:49:19Z |
| format | Article |
| id | doaj.art-e144c9ffe20741778c219edeabcbe0df |
| institution | Directory Open Access Journal |
| issn | 2468-0427 |
| language | English |
| last_indexed | 2024-04-24T08:49:19Z |
| publishDate | 2017-05-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Infectious Disease Modelling |
| spelling | doaj.art-e144c9ffe20741778c219edeabcbe0df2024-04-16T12:54:57ZengKeAi Communications Co., Ltd.Infectious Disease Modelling2468-04272017-05-0122188202In-host modelingStanca M. Ciupe0Jane M. Heffernan1Department of Mathematics, Virginia Tech, Blacksburg, VA, USACentre for Disease Modelling, Department of Mathematics & Statistics, York University, Toronto, ON, Canada; Corresponding author.Understanding the mechanisms governing host-pathogen kinetics is important and can guide human interventions. In-host mathematical models, together with biological data, have been used in this endeavor. In this review, we present basic models used to describe acute and chronic pathogenic infections. We highlight the power of model predictions, the role of drug therapy, and advantage of considering the dynamics of immune responses. We also present the limitations of these models due in part to the trade-off between the complexity of the model and their predictive power, and the challenges a modeler faces in determining the appropriate formulation for a given problem.http://www.sciencedirect.com/science/article/pii/S2468042717300039 |
| spellingShingle | Stanca M. Ciupe Jane M. Heffernan In-host modeling Infectious Disease Modelling |
| title | In-host modeling |
| title_full | In-host modeling |
| title_fullStr | In-host modeling |
| title_full_unstemmed | In-host modeling |
| title_short | In-host modeling |
| title_sort | in host modeling |
| url | http://www.sciencedirect.com/science/article/pii/S2468042717300039 |
| work_keys_str_mv | AT stancamciupe inhostmodeling AT janemheffernan inhostmodeling |