TRP Channels Regulation of Rho GTPases in Brain Context and Diseases
Neurological and neuropsychiatric disorders are mediated by several pathophysiological mechanisms, including developmental and degenerative abnormalities caused primarily by disturbances in cell migration, structural plasticity of the synapse, and blood-vessel barrier function. In this context, crit...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-11-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2020.582975/full |
| _version_ | 1818219337905864704 |
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| author | Boris Lavanderos Boris Lavanderos Ian Silva Ian Silva Pablo Cruz Pablo Cruz Octavio Orellana-Serradell Octavio Orellana-Serradell María Paz Saldías María Paz Saldías Oscar Cerda Oscar Cerda Oscar Cerda |
| author_facet | Boris Lavanderos Boris Lavanderos Ian Silva Ian Silva Pablo Cruz Pablo Cruz Octavio Orellana-Serradell Octavio Orellana-Serradell María Paz Saldías María Paz Saldías Oscar Cerda Oscar Cerda Oscar Cerda |
| author_sort | Boris Lavanderos |
| collection | DOAJ |
| description | Neurological and neuropsychiatric disorders are mediated by several pathophysiological mechanisms, including developmental and degenerative abnormalities caused primarily by disturbances in cell migration, structural plasticity of the synapse, and blood-vessel barrier function. In this context, critical pathways involved in the pathogenesis of these diseases are related to structural, scaffolding, and enzymatic activity-bearing proteins, which participate in Ca2+- and Ras Homologs (Rho) GTPases-mediated signaling. Rho GTPases are GDP/GTP binding proteins that regulate the cytoskeletal structure, cellular protrusion, and migration. These proteins cycle between GTP-bound (active) and GDP-bound (inactive) states due to their intrinsic GTPase activity and their dynamic regulation by GEFs, GAPs, and GDIs. One of the most important upstream inputs that modulate Rho GTPases activity is Ca2+ signaling, positioning ion channels as pivotal molecular entities for Rho GTPases regulation. Multiple non-selective cationic channels belonging to the Transient Receptor Potential (TRP) family participate in cytoskeletal-dependent processes through Ca2+-mediated modulation of Rho GTPases. Moreover, these ion channels have a role in several neuropathological events such as neuronal cell death, brain tumor progression and strokes. Although Rho GTPases-dependent pathways have been extensively studied, how they converge with TRP channels in the development or progression of neuropathologies is poorly understood. Herein, we review recent evidence and insights that link TRP channels activity to downstream Rho GTPase signaling or modulation. Moreover, using the TRIP database, we establish associations between possible mediators of Rho GTPase signaling with TRP ion channels. As such, we propose mechanisms that might explain the TRP-dependent modulation of Rho GTPases as possible pathways participating in the emergence or maintenance of neuropathological conditions. |
| first_indexed | 2024-12-12T07:38:04Z |
| format | Article |
| id | doaj.art-e1464b2807ba4d49bf75d801a9e1560d |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-12T07:38:04Z |
| publishDate | 2020-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-e1464b2807ba4d49bf75d801a9e1560d2022-12-22T00:32:53ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2020-11-01810.3389/fcell.2020.582975582975TRP Channels Regulation of Rho GTPases in Brain Context and DiseasesBoris Lavanderos0Boris Lavanderos1Ian Silva2Ian Silva3Pablo Cruz4Pablo Cruz5Octavio Orellana-Serradell6Octavio Orellana-Serradell7María Paz Saldías8María Paz Saldías9Oscar Cerda10Oscar Cerda11Oscar Cerda12Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago, ChileMillennium Nucleus of Ion Channel-Associated Diseases (MiNICAD), Santiago, ChileProgram of Cellular and Molecular Biology, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago, ChileMillennium Nucleus of Ion Channel-Associated Diseases (MiNICAD), Santiago, ChileProgram of Cellular and Molecular Biology, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago, ChileMillennium Nucleus of Ion Channel-Associated Diseases (MiNICAD), Santiago, ChileProgram of Cellular and Molecular Biology, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago, ChileMillennium Nucleus of Ion Channel-Associated Diseases (MiNICAD), Santiago, ChileProgram of Cellular and Molecular Biology, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago, ChileMillennium Nucleus of Ion Channel-Associated Diseases (MiNICAD), Santiago, ChileProgram of Cellular and Molecular Biology, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago, ChileMillennium Nucleus of Ion Channel-Associated Diseases (MiNICAD), Santiago, ChileThe Wound Repair, Treatment and Health (WoRTH) Initiative, Santiago, ChileNeurological and neuropsychiatric disorders are mediated by several pathophysiological mechanisms, including developmental and degenerative abnormalities caused primarily by disturbances in cell migration, structural plasticity of the synapse, and blood-vessel barrier function. In this context, critical pathways involved in the pathogenesis of these diseases are related to structural, scaffolding, and enzymatic activity-bearing proteins, which participate in Ca2+- and Ras Homologs (Rho) GTPases-mediated signaling. Rho GTPases are GDP/GTP binding proteins that regulate the cytoskeletal structure, cellular protrusion, and migration. These proteins cycle between GTP-bound (active) and GDP-bound (inactive) states due to their intrinsic GTPase activity and their dynamic regulation by GEFs, GAPs, and GDIs. One of the most important upstream inputs that modulate Rho GTPases activity is Ca2+ signaling, positioning ion channels as pivotal molecular entities for Rho GTPases regulation. Multiple non-selective cationic channels belonging to the Transient Receptor Potential (TRP) family participate in cytoskeletal-dependent processes through Ca2+-mediated modulation of Rho GTPases. Moreover, these ion channels have a role in several neuropathological events such as neuronal cell death, brain tumor progression and strokes. Although Rho GTPases-dependent pathways have been extensively studied, how they converge with TRP channels in the development or progression of neuropathologies is poorly understood. Herein, we review recent evidence and insights that link TRP channels activity to downstream Rho GTPase signaling or modulation. Moreover, using the TRIP database, we establish associations between possible mediators of Rho GTPase signaling with TRP ion channels. As such, we propose mechanisms that might explain the TRP-dependent modulation of Rho GTPases as possible pathways participating in the emergence or maintenance of neuropathological conditions.https://www.frontiersin.org/articles/10.3389/fcell.2020.582975/fullTRP channelsRho GTPasesactin cytoskeletonTRP interactomeGEFsGAPs |
| spellingShingle | Boris Lavanderos Boris Lavanderos Ian Silva Ian Silva Pablo Cruz Pablo Cruz Octavio Orellana-Serradell Octavio Orellana-Serradell María Paz Saldías María Paz Saldías Oscar Cerda Oscar Cerda Oscar Cerda TRP Channels Regulation of Rho GTPases in Brain Context and Diseases Frontiers in Cell and Developmental Biology TRP channels Rho GTPases actin cytoskeleton TRP interactome GEFs GAPs |
| title | TRP Channels Regulation of Rho GTPases in Brain Context and Diseases |
| title_full | TRP Channels Regulation of Rho GTPases in Brain Context and Diseases |
| title_fullStr | TRP Channels Regulation of Rho GTPases in Brain Context and Diseases |
| title_full_unstemmed | TRP Channels Regulation of Rho GTPases in Brain Context and Diseases |
| title_short | TRP Channels Regulation of Rho GTPases in Brain Context and Diseases |
| title_sort | trp channels regulation of rho gtpases in brain context and diseases |
| topic | TRP channels Rho GTPases actin cytoskeleton TRP interactome GEFs GAPs |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2020.582975/full |
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