Efficacy of Mid-Second-Trimester Serum b-HCG Levels as a Predictor of Hypertensive Disorders of Pregnancy: A Longitudinal Cohort Study
Introduction: Hypertensive Disorders of Pregnancy (HDP) affect up to 10% of pregnancies worldwide, despite improvements in maternal and neonatal care. HDP and its sequelae are a dreaded complication of pregnancy. If prediction becomes possible, prevention will follow naturally. Aim: To study th...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2023-07-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://www.jcdr.net/articles/PDF/18140/63954_CE[Ra1]_F(IS)_PF1(HJ_IS_OM)_PF2(AVG_HJ_OM)_PFA(HJ_KM)_PN(KM).pdf |
| Summary: | Introduction: Hypertensive Disorders of Pregnancy (HDP) affect
up to 10% of pregnancies worldwide, despite improvements in
maternal and neonatal care. HDP and its sequelae are a dreaded
complication of pregnancy. If prediction becomes possible,
prevention will follow naturally.
Aim: To study the efficacy of mid-second trimester serum
b-hCG levels in the prediction of HDP.
Materials and Methods: This was a longitudinal cohort study
conducted in the Department of Obstetrics and Gynaecology at
Shri BM Patil Medical College Hospital and Research Centre ,
Vijayapura, Karnataka, India, between December 2020 and June
2022. All women with gestational age between 16-20 weeks
were screened, and 163 pregnant women were enrolled in the
study. Serum β-hCG levels were measured at enrollment, and
values were followed-up until delivery. The development of HDP
was evaluated using statistical analysis, including Chi-square,
Independent t-test, Receiver Operating Curve/Area under the
ROC Curve (ROC/AUC), sensitivity, and specificity. A p-value of
<0.05 was considered significant.
Results: Of the 163 pregnant women enrolled, 49 (30.1%)
developed HDP, while 114 (69.9%) remained normotensive.
The mean age of the study population was 24±4 years. The
mean serum β-hCG level in the normotensive group was 55666
mIU/mL, while in the HDP group, it was 100124 mIU/mL, with a
statistically significant p-value of 0.001. A cut-off value of 77817
mIU/mL showed 83.7% sensitivity and 92.1% specificity.
Conclusion: This study suggests that serum b-hCG levels
between 16-20 weeks can be used as a non-invasive predictor
of HDP. It is a good predictor of HDP and could potentially
improve prevention strategies. |
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| ISSN: | 2249-782X 0973-709X |