Efficacy of Mid-Second-Trimester Serum b-HCG Levels as a Predictor of Hypertensive Disorders of Pregnancy: A Longitudinal Cohort Study
Introduction: Hypertensive Disorders of Pregnancy (HDP) affect up to 10% of pregnancies worldwide, despite improvements in maternal and neonatal care. HDP and its sequelae are a dreaded complication of pregnancy. If prediction becomes possible, prevention will follow naturally. Aim: To study th...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2023-07-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://www.jcdr.net/articles/PDF/18140/63954_CE[Ra1]_F(IS)_PF1(HJ_IS_OM)_PF2(AVG_HJ_OM)_PFA(HJ_KM)_PN(KM).pdf |
| _version_ | 1797783267840098304 |
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| author | Kada Vishnu Priya Shilaja Rajendra Bidri Sangamesh Mathapati |
| author_facet | Kada Vishnu Priya Shilaja Rajendra Bidri Sangamesh Mathapati |
| author_sort | Kada Vishnu Priya |
| collection | DOAJ |
| description | Introduction: Hypertensive Disorders of Pregnancy (HDP) affect
up to 10% of pregnancies worldwide, despite improvements in
maternal and neonatal care. HDP and its sequelae are a dreaded
complication of pregnancy. If prediction becomes possible,
prevention will follow naturally.
Aim: To study the efficacy of mid-second trimester serum
b-hCG levels in the prediction of HDP.
Materials and Methods: This was a longitudinal cohort study
conducted in the Department of Obstetrics and Gynaecology at
Shri BM Patil Medical College Hospital and Research Centre ,
Vijayapura, Karnataka, India, between December 2020 and June
2022. All women with gestational age between 16-20 weeks
were screened, and 163 pregnant women were enrolled in the
study. Serum β-hCG levels were measured at enrollment, and
values were followed-up until delivery. The development of HDP
was evaluated using statistical analysis, including Chi-square,
Independent t-test, Receiver Operating Curve/Area under the
ROC Curve (ROC/AUC), sensitivity, and specificity. A p-value of
<0.05 was considered significant.
Results: Of the 163 pregnant women enrolled, 49 (30.1%)
developed HDP, while 114 (69.9%) remained normotensive.
The mean age of the study population was 24±4 years. The
mean serum β-hCG level in the normotensive group was 55666
mIU/mL, while in the HDP group, it was 100124 mIU/mL, with a
statistically significant p-value of 0.001. A cut-off value of 77817
mIU/mL showed 83.7% sensitivity and 92.1% specificity.
Conclusion: This study suggests that serum b-hCG levels
between 16-20 weeks can be used as a non-invasive predictor
of HDP. It is a good predictor of HDP and could potentially
improve prevention strategies. |
| first_indexed | 2024-03-13T00:23:38Z |
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| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-03-13T00:23:38Z |
| publishDate | 2023-07-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-e147e60da33a4dcf97675e88c222b5872023-07-11T09:17:59ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2023-07-01177010310.7860/JCDR/2023/63954.18140Efficacy of Mid-Second-Trimester Serum b-HCG Levels as a Predictor of Hypertensive Disorders of Pregnancy: A Longitudinal Cohort StudyKada Vishnu Priya0Shilaja Rajendra Bidri1Sangamesh Mathapati2Undergraduate, Department of Obstetrics and Gynaecology, Shri BM Patil Medical College, Hospital and Research Centre, Vijayapura, Karnataka, India.Postgraduate, Department of Obstetrics and Gynaecology, Shri BM Patil Medical College, Hospital and Research Centre, Vijayapura, Karnataka, India.Postgraduate, Department of Obstetrics and Gynaecology, Shri BM Patil Medical College, Hospital and Research Centre, Vijayapura, Karnataka, India.Introduction: Hypertensive Disorders of Pregnancy (HDP) affect up to 10% of pregnancies worldwide, despite improvements in maternal and neonatal care. HDP and its sequelae are a dreaded complication of pregnancy. If prediction becomes possible, prevention will follow naturally. Aim: To study the efficacy of mid-second trimester serum b-hCG levels in the prediction of HDP. Materials and Methods: This was a longitudinal cohort study conducted in the Department of Obstetrics and Gynaecology at Shri BM Patil Medical College Hospital and Research Centre , Vijayapura, Karnataka, India, between December 2020 and June 2022. All women with gestational age between 16-20 weeks were screened, and 163 pregnant women were enrolled in the study. Serum β-hCG levels were measured at enrollment, and values were followed-up until delivery. The development of HDP was evaluated using statistical analysis, including Chi-square, Independent t-test, Receiver Operating Curve/Area under the ROC Curve (ROC/AUC), sensitivity, and specificity. A p-value of <0.05 was considered significant. Results: Of the 163 pregnant women enrolled, 49 (30.1%) developed HDP, while 114 (69.9%) remained normotensive. The mean age of the study population was 24±4 years. The mean serum β-hCG level in the normotensive group was 55666 mIU/mL, while in the HDP group, it was 100124 mIU/mL, with a statistically significant p-value of 0.001. A cut-off value of 77817 mIU/mL showed 83.7% sensitivity and 92.1% specificity. Conclusion: This study suggests that serum b-hCG levels between 16-20 weeks can be used as a non-invasive predictor of HDP. It is a good predictor of HDP and could potentially improve prevention strategies.https://www.jcdr.net/articles/PDF/18140/63954_CE[Ra1]_F(IS)_PF1(HJ_IS_OM)_PF2(AVG_HJ_OM)_PFA(HJ_KM)_PN(KM).pdfhypertensivenormotensivepregnancysensitivity |
| spellingShingle | Kada Vishnu Priya Shilaja Rajendra Bidri Sangamesh Mathapati Efficacy of Mid-Second-Trimester Serum b-HCG Levels as a Predictor of Hypertensive Disorders of Pregnancy: A Longitudinal Cohort Study Journal of Clinical and Diagnostic Research hypertensive normotensive pregnancy sensitivity |
| title | Efficacy of Mid-Second-Trimester Serum b-HCG Levels as a Predictor of Hypertensive Disorders of Pregnancy: A Longitudinal Cohort Study |
| title_full | Efficacy of Mid-Second-Trimester Serum b-HCG Levels as a Predictor of Hypertensive Disorders of Pregnancy: A Longitudinal Cohort Study |
| title_fullStr | Efficacy of Mid-Second-Trimester Serum b-HCG Levels as a Predictor of Hypertensive Disorders of Pregnancy: A Longitudinal Cohort Study |
| title_full_unstemmed | Efficacy of Mid-Second-Trimester Serum b-HCG Levels as a Predictor of Hypertensive Disorders of Pregnancy: A Longitudinal Cohort Study |
| title_short | Efficacy of Mid-Second-Trimester Serum b-HCG Levels as a Predictor of Hypertensive Disorders of Pregnancy: A Longitudinal Cohort Study |
| title_sort | efficacy of mid second trimester serum b hcg levels as a predictor of hypertensive disorders of pregnancy a longitudinal cohort study |
| topic | hypertensive normotensive pregnancy sensitivity |
| url | https://www.jcdr.net/articles/PDF/18140/63954_CE[Ra1]_F(IS)_PF1(HJ_IS_OM)_PF2(AVG_HJ_OM)_PFA(HJ_KM)_PN(KM).pdf |
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