Iron status is inversely associated with dietary iron intakes in patients with inactive or mildly active inflammatory bowel disease
<p>Abstract</p> <p>Background</p> <p>Patients with inflammatory bowel disease (IBD) frequently appear iron deplete but whether this is a reflection of dietary iron intakes is not known.</p> <p>Methods</p> <p>Dietary data were collected from 29 pa...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2013-02-01
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| Series: | Nutrition & Metabolism |
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| Online Access: | http://www.nutritionandmetabolism.com/content/10/1/18 |
| _version_ | 1811266435202154496 |
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| author | Powell Jonathan J Cook William B Chatfield Mark Hutchinson Carol Pereira Dora IA Lomer Miranda CE |
| author_facet | Powell Jonathan J Cook William B Chatfield Mark Hutchinson Carol Pereira Dora IA Lomer Miranda CE |
| author_sort | Powell Jonathan J |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Patients with inflammatory bowel disease (IBD) frequently appear iron deplete but whether this is a reflection of dietary iron intakes is not known.</p> <p>Methods</p> <p>Dietary data were collected from 29 patients with inactive or mildly-active IBD and 28 healthy controls using a validated food frequency questionnaire that measured intakes of iron and its absorption modifiers. Non-haem iron availability was estimated using a recently developed algorithm. Subjects were classified for iron status based upon data from a concomitant and separately published study of iron absorption. Absorption was used to define iron status because haematological parameters are flawed in assessing iron status in inflammatory conditions such as IBD.</p> <p>Results</p> <p>Dietary intakes of total iron, non-haem iron and vitamin C were significantly greater in IBD patients who were iron replete compared to those who were iron deplete (by 48%, 48% and 94% respectively; <it>p</it>≤0.05). The predicted percentage of available non-haem iron did not differ between these groups (19.7 ± 2.0% <it>vs</it> 19.3 ± 2.0% respectively; <it>p</it>=0.25). However, because of the difference in iron intake, the overall amount of absorbed iron did (2.4 ± 0.8 mg/d <it>vs</it> 1.7 ± 0.5 mg/d; <it>p</it>=0.013). No such differences were observed in the healthy control subjects.</p> <p>Conclusions</p> <p>In IBD, iron status is more closely related to the quality and quantity of dietary iron intake than in the general healthy population.</p> |
| first_indexed | 2024-04-12T20:43:07Z |
| format | Article |
| id | doaj.art-e1488ed5e2614db2a0daaaa4017798ec |
| institution | Directory Open Access Journal |
| issn | 1743-7075 |
| language | English |
| last_indexed | 2024-04-12T20:43:07Z |
| publishDate | 2013-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Nutrition & Metabolism |
| spelling | doaj.art-e1488ed5e2614db2a0daaaa4017798ec2022-12-22T03:17:22ZengBMCNutrition & Metabolism1743-70752013-02-011011810.1186/1743-7075-10-18Iron status is inversely associated with dietary iron intakes in patients with inactive or mildly active inflammatory bowel diseasePowell Jonathan JCook William BChatfield MarkHutchinson CarolPereira Dora IALomer Miranda CE<p>Abstract</p> <p>Background</p> <p>Patients with inflammatory bowel disease (IBD) frequently appear iron deplete but whether this is a reflection of dietary iron intakes is not known.</p> <p>Methods</p> <p>Dietary data were collected from 29 patients with inactive or mildly-active IBD and 28 healthy controls using a validated food frequency questionnaire that measured intakes of iron and its absorption modifiers. Non-haem iron availability was estimated using a recently developed algorithm. Subjects were classified for iron status based upon data from a concomitant and separately published study of iron absorption. Absorption was used to define iron status because haematological parameters are flawed in assessing iron status in inflammatory conditions such as IBD.</p> <p>Results</p> <p>Dietary intakes of total iron, non-haem iron and vitamin C were significantly greater in IBD patients who were iron replete compared to those who were iron deplete (by 48%, 48% and 94% respectively; <it>p</it>≤0.05). The predicted percentage of available non-haem iron did not differ between these groups (19.7 ± 2.0% <it>vs</it> 19.3 ± 2.0% respectively; <it>p</it>=0.25). However, because of the difference in iron intake, the overall amount of absorbed iron did (2.4 ± 0.8 mg/d <it>vs</it> 1.7 ± 0.5 mg/d; <it>p</it>=0.013). No such differences were observed in the healthy control subjects.</p> <p>Conclusions</p> <p>In IBD, iron status is more closely related to the quality and quantity of dietary iron intake than in the general healthy population.</p>http://www.nutritionandmetabolism.com/content/10/1/18IBDIron deficiency anaemiaIron intakeDietFood frequency questionnaire |
| spellingShingle | Powell Jonathan J Cook William B Chatfield Mark Hutchinson Carol Pereira Dora IA Lomer Miranda CE Iron status is inversely associated with dietary iron intakes in patients with inactive or mildly active inflammatory bowel disease Nutrition & Metabolism IBD Iron deficiency anaemia Iron intake Diet Food frequency questionnaire |
| title | Iron status is inversely associated with dietary iron intakes in patients with inactive or mildly active inflammatory bowel disease |
| title_full | Iron status is inversely associated with dietary iron intakes in patients with inactive or mildly active inflammatory bowel disease |
| title_fullStr | Iron status is inversely associated with dietary iron intakes in patients with inactive or mildly active inflammatory bowel disease |
| title_full_unstemmed | Iron status is inversely associated with dietary iron intakes in patients with inactive or mildly active inflammatory bowel disease |
| title_short | Iron status is inversely associated with dietary iron intakes in patients with inactive or mildly active inflammatory bowel disease |
| title_sort | iron status is inversely associated with dietary iron intakes in patients with inactive or mildly active inflammatory bowel disease |
| topic | IBD Iron deficiency anaemia Iron intake Diet Food frequency questionnaire |
| url | http://www.nutritionandmetabolism.com/content/10/1/18 |
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