Aspirin, platelet inhibition and cancer prevention
Several lines of evidence are consistent with the hypothesis that activated platelets contribute to colorectal tumorigenesis and metastatization through direct cell–cell interactions and the release of different lipid and protein mediators, and microvesicles. This review examines the clinical pharma...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2018-11-01
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| Series: | Platelets |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09537104.2018.1492105 |
| _version_ | 1827816953991921664 |
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| author | Paola Patrignani Carlo Patrono |
| author_facet | Paola Patrignani Carlo Patrono |
| author_sort | Paola Patrignani |
| collection | DOAJ |
| description | Several lines of evidence are consistent with the hypothesis that activated platelets contribute to colorectal tumorigenesis and metastatization through direct cell–cell interactions and the release of different lipid and protein mediators, and microvesicles. This review examines the clinical pharmacology of low-dose aspirin as a basis for discussing the mechanisms underlying the contribution of platelets to neoplastic transformation and progression of cancer via the development of metastases. |
| first_indexed | 2024-03-12T00:27:36Z |
| format | Article |
| id | doaj.art-e148ea2e3af84ba5a4d8344896894141 |
| institution | Directory Open Access Journal |
| issn | 0953-7104 1369-1635 |
| language | English |
| last_indexed | 2024-03-12T00:27:36Z |
| publishDate | 2018-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Platelets |
| spelling | doaj.art-e148ea2e3af84ba5a4d83448968941412023-09-15T10:32:00ZengTaylor & Francis GroupPlatelets0953-71041369-16352018-11-0129877978510.1080/09537104.2018.14921051492105Aspirin, platelet inhibition and cancer preventionPaola Patrignani0Carlo Patrono1“G. d’Annunzio” UniversityCatholic University School of MedicineSeveral lines of evidence are consistent with the hypothesis that activated platelets contribute to colorectal tumorigenesis and metastatization through direct cell–cell interactions and the release of different lipid and protein mediators, and microvesicles. This review examines the clinical pharmacology of low-dose aspirin as a basis for discussing the mechanisms underlying the contribution of platelets to neoplastic transformation and progression of cancer via the development of metastases.http://dx.doi.org/10.1080/09537104.2018.1492105aspirincolorectal cancercyclooxygenasesplatelet activationprostaglandin e2thromboxane a2 |
| spellingShingle | Paola Patrignani Carlo Patrono Aspirin, platelet inhibition and cancer prevention Platelets aspirin colorectal cancer cyclooxygenases platelet activation prostaglandin e2 thromboxane a2 |
| title | Aspirin, platelet inhibition and cancer prevention |
| title_full | Aspirin, platelet inhibition and cancer prevention |
| title_fullStr | Aspirin, platelet inhibition and cancer prevention |
| title_full_unstemmed | Aspirin, platelet inhibition and cancer prevention |
| title_short | Aspirin, platelet inhibition and cancer prevention |
| title_sort | aspirin platelet inhibition and cancer prevention |
| topic | aspirin colorectal cancer cyclooxygenases platelet activation prostaglandin e2 thromboxane a2 |
| url | http://dx.doi.org/10.1080/09537104.2018.1492105 |
| work_keys_str_mv | AT paolapatrignani aspirinplateletinhibitionandcancerprevention AT carlopatrono aspirinplateletinhibitionandcancerprevention |