Nanopore-CMOS Interfaces for DNA Sequencing
DNA sequencers based on nanopore sensors present an opportunity for a significant break from the template-based incumbents of the last forty years. Key advantages ushered by nanopore technology include a simplified chemistry and the ability to interface to CMOS technology. The latter opportunity off...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-08-01
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| Series: | Biosensors |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2079-6374/6/3/42 |
| _version_ | 1828931118866366464 |
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| author | Sebastian Magierowski Yiyun Huang Chengjie Wang Ebrahim Ghafar-Zadeh |
| author_facet | Sebastian Magierowski Yiyun Huang Chengjie Wang Ebrahim Ghafar-Zadeh |
| author_sort | Sebastian Magierowski |
| collection | DOAJ |
| description | DNA sequencers based on nanopore sensors present an opportunity for a significant break from the template-based incumbents of the last forty years. Key advantages ushered by nanopore technology include a simplified chemistry and the ability to interface to CMOS technology. The latter opportunity offers substantial promise for improvement in sequencing speed, size and cost. This paper reviews existing and emerging means of interfacing nanopores to CMOS technology with an emphasis on massively-arrayed structures. It presents this in the context of incumbent DNA sequencing techniques, reviews and quantifies nanopore characteristics and models and presents CMOS circuit methods for the amplification of low-current nanopore signals in such interfaces. |
| first_indexed | 2024-12-14T00:42:08Z |
| format | Article |
| id | doaj.art-e14906e8ace042d99b4a227d5a78dd56 |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-12-14T00:42:08Z |
| publishDate | 2016-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-e14906e8ace042d99b4a227d5a78dd562022-12-21T23:24:19ZengMDPI AGBiosensors2079-63742016-08-01634210.3390/bios6030042bios6030042Nanopore-CMOS Interfaces for DNA SequencingSebastian Magierowski0Yiyun Huang1Chengjie Wang2Ebrahim Ghafar-Zadeh3Department of Electrical Engineering and Computer Science, York University, 6400 Keele St, Toronto, ON M3J-1P3, CanadaDepartment of Electrical Engineering and Computer Science, York University, 6400 Keele St, Toronto, ON M3J-1P3, CanadaDepartment of Electrical Engineering and Computer Science, York University, 6400 Keele St, Toronto, ON M3J-1P3, CanadaDepartment of Electrical Engineering and Computer Science, York University, 6400 Keele St, Toronto, ON M3J-1P3, CanadaDNA sequencers based on nanopore sensors present an opportunity for a significant break from the template-based incumbents of the last forty years. Key advantages ushered by nanopore technology include a simplified chemistry and the ability to interface to CMOS technology. The latter opportunity offers substantial promise for improvement in sequencing speed, size and cost. This paper reviews existing and emerging means of interfacing nanopores to CMOS technology with an emphasis on massively-arrayed structures. It presents this in the context of incumbent DNA sequencing techniques, reviews and quantifies nanopore characteristics and models and presents CMOS circuit methods for the amplification of low-current nanopore signals in such interfaces.http://www.mdpi.com/2079-6374/6/3/42nanopore sensorsmicroelectronicssequencingCMOSnanopore arraystransimpedance amplification |
| spellingShingle | Sebastian Magierowski Yiyun Huang Chengjie Wang Ebrahim Ghafar-Zadeh Nanopore-CMOS Interfaces for DNA Sequencing Biosensors nanopore sensors microelectronics sequencing CMOS nanopore arrays transimpedance amplification |
| title | Nanopore-CMOS Interfaces for DNA Sequencing |
| title_full | Nanopore-CMOS Interfaces for DNA Sequencing |
| title_fullStr | Nanopore-CMOS Interfaces for DNA Sequencing |
| title_full_unstemmed | Nanopore-CMOS Interfaces for DNA Sequencing |
| title_short | Nanopore-CMOS Interfaces for DNA Sequencing |
| title_sort | nanopore cmos interfaces for dna sequencing |
| topic | nanopore sensors microelectronics sequencing CMOS nanopore arrays transimpedance amplification |
| url | http://www.mdpi.com/2079-6374/6/3/42 |
| work_keys_str_mv | AT sebastianmagierowski nanoporecmosinterfacesfordnasequencing AT yiyunhuang nanoporecmosinterfacesfordnasequencing AT chengjiewang nanoporecmosinterfacesfordnasequencing AT ebrahimghafarzadeh nanoporecmosinterfacesfordnasequencing |