A study of elevated red cell distribution width (RDW) in early-onset neonatal sepsis
Abstract Background Neonatal sepsis is a serious infection occurring within the first 28 days of life. It is a significant cause of mortality and morbidity. Red cell distribution width (RDW) is estimated within the standard CBC profile and considered a simple tool for the diagnosis of neonatal sepsi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-08-01
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| Series: | Egyptian Pediatric Association Gazette |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43054-022-00112-3 |
| _version_ | 1811340123194785792 |
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| author | Mahmoud Hodeib Dalia Morgan Aya Hedaya Nevien Waked |
| author_facet | Mahmoud Hodeib Dalia Morgan Aya Hedaya Nevien Waked |
| author_sort | Mahmoud Hodeib |
| collection | DOAJ |
| description | Abstract Background Neonatal sepsis is a serious infection occurring within the first 28 days of life. It is a significant cause of mortality and morbidity. Red cell distribution width (RDW) is estimated within the standard CBC profile and considered a simple tool for the diagnosis of neonatal sepsis without additional cost. Our aim in this study is to investigate the potential role of red cell distribution width (RDW) in the diagnosis of early-onset neonatal sepsis (EONS). The aim of our study is to detect the role of red cell distribution width (RDW) in the diagnosis and prognosis of early-onset neonatal sepsis (EONS). Results This case-control study was conducted at the NICU of Beni-Suef University Hospital and revealed that RDW% was highly significantly higher among cases than among controls (16.65 ± 4.28, 11.13 ± 0.62, respectively); regarding the severity of neonatal sepsis, we divided our cases into three groups (sepsis group includes 21 neonates, severe sepsis group includes 31 neonates, and septic shock group includes 48 neonates), there were statistically significant differences between the three groups (sepsis, severe sepsis, and septic shock) regarding RDW (15.15 ± 1.65, 16.78 ± 2.01, 17.02 ± 2.02, respectively) as P value (0.027). Conclusion This study revealed that RDW is associated with the diagnosis and prognosis of early-onset neonatal sepsis, so further study is needed to prove causation as it is being simple, less expensive, available, and easily repeated as it is routinely done with CBC, so it will be a good indicator for prognosis of neonatal sepsis. |
| first_indexed | 2024-04-13T18:37:32Z |
| format | Article |
| id | doaj.art-e1493d9c7dd24f80a3d2c32d1e7afb2c |
| institution | Directory Open Access Journal |
| issn | 2090-9942 |
| language | English |
| last_indexed | 2024-04-13T18:37:32Z |
| publishDate | 2022-08-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Egyptian Pediatric Association Gazette |
| spelling | doaj.art-e1493d9c7dd24f80a3d2c32d1e7afb2c2022-12-22T02:34:51ZengSpringerOpenEgyptian Pediatric Association Gazette2090-99422022-08-017011610.1186/s43054-022-00112-3A study of elevated red cell distribution width (RDW) in early-onset neonatal sepsisMahmoud Hodeib0Dalia Morgan1Aya Hedaya2Nevien Waked3Pediatric Department, Faculty of Medicine, Beni-Suef UniversityPediatric Department, Faculty of Medicine, Beni-Suef UniversityOctober 6 University HospitalPediatric Department, Faculty of Medicine, October 6 UniversityAbstract Background Neonatal sepsis is a serious infection occurring within the first 28 days of life. It is a significant cause of mortality and morbidity. Red cell distribution width (RDW) is estimated within the standard CBC profile and considered a simple tool for the diagnosis of neonatal sepsis without additional cost. Our aim in this study is to investigate the potential role of red cell distribution width (RDW) in the diagnosis of early-onset neonatal sepsis (EONS). The aim of our study is to detect the role of red cell distribution width (RDW) in the diagnosis and prognosis of early-onset neonatal sepsis (EONS). Results This case-control study was conducted at the NICU of Beni-Suef University Hospital and revealed that RDW% was highly significantly higher among cases than among controls (16.65 ± 4.28, 11.13 ± 0.62, respectively); regarding the severity of neonatal sepsis, we divided our cases into three groups (sepsis group includes 21 neonates, severe sepsis group includes 31 neonates, and septic shock group includes 48 neonates), there were statistically significant differences between the three groups (sepsis, severe sepsis, and septic shock) regarding RDW (15.15 ± 1.65, 16.78 ± 2.01, 17.02 ± 2.02, respectively) as P value (0.027). Conclusion This study revealed that RDW is associated with the diagnosis and prognosis of early-onset neonatal sepsis, so further study is needed to prove causation as it is being simple, less expensive, available, and easily repeated as it is routinely done with CBC, so it will be a good indicator for prognosis of neonatal sepsis.https://doi.org/10.1186/s43054-022-00112-3Red cell distribution widthNeonatal sepsisEarly-onset neonatal sepsis |
| spellingShingle | Mahmoud Hodeib Dalia Morgan Aya Hedaya Nevien Waked A study of elevated red cell distribution width (RDW) in early-onset neonatal sepsis Egyptian Pediatric Association Gazette Red cell distribution width Neonatal sepsis Early-onset neonatal sepsis |
| title | A study of elevated red cell distribution width (RDW) in early-onset neonatal sepsis |
| title_full | A study of elevated red cell distribution width (RDW) in early-onset neonatal sepsis |
| title_fullStr | A study of elevated red cell distribution width (RDW) in early-onset neonatal sepsis |
| title_full_unstemmed | A study of elevated red cell distribution width (RDW) in early-onset neonatal sepsis |
| title_short | A study of elevated red cell distribution width (RDW) in early-onset neonatal sepsis |
| title_sort | study of elevated red cell distribution width rdw in early onset neonatal sepsis |
| topic | Red cell distribution width Neonatal sepsis Early-onset neonatal sepsis |
| url | https://doi.org/10.1186/s43054-022-00112-3 |
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