CD40 Agonist Monoclonal Antibody-Mediated Hepatitis in TNF-Receptor 1 Gene Knockout Mice

CD40 Agonist Monoclonal Antibody-Mediated Hepatitis in TNF-Receptor 1 Gene Knockout Mice

Tumor necrosis factor-alpha (TNF-α) plays an important role in liver inflammation. CD40-CD40 ligand (CD40-CD40L) is a key receptor–ligand signaling pair involved in the adaptive immune response and pathogenesis of autoimmune diseases. In mice, CD40 activation leads to sickness behavior syndrome (SBS...

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Bibliographic Details
Main Authors: Oksana Raabe, Thomas Birchler, Hubert Rehrauer, Elisabeth Eppler
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Biomedicines
Subjects:
TNF-α
TNF receptor 1
CD40 activation
autoimmune hepatitis
mouse model
SBS
Online Access:https://www.mdpi.com/2227-9059/9/8/863

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