Leptin resistance in patients with nonalcoholic fatty liver disease associated with obesity and overweight
Aim: to study the association of the levels of leptin and its soluble receptor in blood serum with nonalcoholic fatty liver disease (NAFLD) in obese or overweight patients. Material and methods: the open study included 105 patients with obesity or excess body weight. Patients were examined for NAFLD...
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| Format: | Article |
| Language: | Russian |
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Remedium Group LLC
2015-12-01
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| Series: | Медицинский совет |
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| Online Access: | https://www.med-sovet.pro/jour/article/view/336 |
| _version_ | 1797841934594605056 |
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| author | M. A. Livzan I. V. Lapteva T. S. Krolevets N. A. Cherkaschenko |
| author_facet | M. A. Livzan I. V. Lapteva T. S. Krolevets N. A. Cherkaschenko |
| author_sort | M. A. Livzan |
| collection | DOAJ |
| description | Aim: to study the association of the levels of leptin and its soluble receptor in blood serum with nonalcoholic fatty liver disease (NAFLD) in obese or overweight patients. Material and methods: the open study included 105 patients with obesity or excess body weight. Patients were examined for NAFLD and divided into two groups: the treatment group included patients with NAFLD (n = 77) and the control group included patients without NAFLD (n = 28). Results: complaints of pain in the right upper quadrant, hypertension and diabetes type 2, as well as waist circumference, body mass index, glucose and triglyceride levels were reported significantly more frequently in the group of patients with NAFLD. Leptin was positively and the level of its receptors was negatively correlated with the degree of weight gain. Between these parameters in the group of patients with obesity and excess body weight, an overall moderate negative correlation was reported (rs = (-0.370), p |
| first_indexed | 2024-04-09T16:39:33Z |
| format | Article |
| id | doaj.art-e14c51d8ee1341deb2939f4f893f13f0 |
| institution | Directory Open Access Journal |
| issn | 2079-701X 2658-5790 |
| language | Russian |
| last_indexed | 2024-04-09T16:39:33Z |
| publishDate | 2015-12-01 |
| publisher | Remedium Group LLC |
| record_format | Article |
| series | Медицинский совет |
| spelling | doaj.art-e14c51d8ee1341deb2939f4f893f13f02023-04-23T06:56:47ZrusRemedium Group LLCМедицинский совет2079-701X2658-57902015-12-01013586310.21518/2079-701X-2015-13-58-63336Leptin resistance in patients with nonalcoholic fatty liver disease associated with obesity and overweightM. A. Livzan0I. V. Lapteva1T. S. Krolevets2N. A. Cherkaschenko3Omsk State Medical University, Russia's Ministry of HealthOmsk State Medical University, Russia's Ministry of HealthOmsk State Medical University, Russia's Ministry of HealthOmsk State Medical University, Russia's Ministry of HealthAim: to study the association of the levels of leptin and its soluble receptor in blood serum with nonalcoholic fatty liver disease (NAFLD) in obese or overweight patients. Material and methods: the open study included 105 patients with obesity or excess body weight. Patients were examined for NAFLD and divided into two groups: the treatment group included patients with NAFLD (n = 77) and the control group included patients without NAFLD (n = 28). Results: complaints of pain in the right upper quadrant, hypertension and diabetes type 2, as well as waist circumference, body mass index, glucose and triglyceride levels were reported significantly more frequently in the group of patients with NAFLD. Leptin was positively and the level of its receptors was negatively correlated with the degree of weight gain. Between these parameters in the group of patients with obesity and excess body weight, an overall moderate negative correlation was reported (rs = (-0.370), phttps://www.med-sovet.pro/jour/article/view/336ожирениеизбыток массы теланеалкогольная жировая болезнь печенилептинлептинорезистентностьobesityexcess body weightnon-alcoholic fatty liver diseaseleptinleptin resistance |
| spellingShingle | M. A. Livzan I. V. Lapteva T. S. Krolevets N. A. Cherkaschenko Leptin resistance in patients with nonalcoholic fatty liver disease associated with obesity and overweight Медицинский совет ожирение избыток массы тела неалкогольная жировая болезнь печени лептин лептинорезистентность obesity excess body weight non-alcoholic fatty liver disease leptin leptin resistance |
| title | Leptin resistance in patients with nonalcoholic fatty liver disease associated with obesity and overweight |
| title_full | Leptin resistance in patients with nonalcoholic fatty liver disease associated with obesity and overweight |
| title_fullStr | Leptin resistance in patients with nonalcoholic fatty liver disease associated with obesity and overweight |
| title_full_unstemmed | Leptin resistance in patients with nonalcoholic fatty liver disease associated with obesity and overweight |
| title_short | Leptin resistance in patients with nonalcoholic fatty liver disease associated with obesity and overweight |
| title_sort | leptin resistance in patients with nonalcoholic fatty liver disease associated with obesity and overweight |
| topic | ожирение избыток массы тела неалкогольная жировая болезнь печени лептин лептинорезистентность obesity excess body weight non-alcoholic fatty liver disease leptin leptin resistance |
| url | https://www.med-sovet.pro/jour/article/view/336 |
| work_keys_str_mv | AT malivzan leptinresistanceinpatientswithnonalcoholicfattyliverdiseaseassociatedwithobesityandoverweight AT ivlapteva leptinresistanceinpatientswithnonalcoholicfattyliverdiseaseassociatedwithobesityandoverweight AT tskrolevets leptinresistanceinpatientswithnonalcoholicfattyliverdiseaseassociatedwithobesityandoverweight AT nacherkaschenko leptinresistanceinpatientswithnonalcoholicfattyliverdiseaseassociatedwithobesityandoverweight |