Transporters for Bile Formation in Physiology and Pathophysiology
The liver fulfills many vital functions for the body, among them bile formation and detoxification. Bile salts are organic anions, are the major constituents of bile and are at high concentrations cytotoxic. Detoxification exposes the liver to many harmful compounds. This function is therefore pote...
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| Format: | Article |
| Language: | deu |
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Swiss Chemical Society
2022-12-01
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| Series: | CHIMIA |
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| Online Access: | https://chimia.ch/chimia/article/view/6107 |
| _version_ | 1811166369542045696 |
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| author | Bruno Stieger |
| author_facet | Bruno Stieger |
| author_sort | Bruno Stieger |
| collection | DOAJ |
| description |
The liver fulfills many vital functions for the body, among them bile formation and detoxification. Bile salts are organic anions, are the major constituents of bile and are at high concentrations cytotoxic. Detoxification exposes the liver to many harmful compounds. This function is therefore potentially damaging to the liver. Impaired bile formation may lead to hepatic accumulation of bile salts and subsequently to liver disease. Diagnosis of liver diseases involves the measurement of so-called liver function parameters. This overview aims to characterize and summarize the role of organic anion transporters in bile formation at the protein level under normal physiologic conditions and in liver function tests used for diagnosing liver diseases in pathophysiologic situations.
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| first_indexed | 2024-04-10T15:51:09Z |
| format | Article |
| id | doaj.art-e14cc26d41c14406a59674cdda2a2868 |
| institution | Directory Open Access Journal |
| issn | 0009-4293 2673-2424 |
| language | deu |
| last_indexed | 2024-04-10T15:51:09Z |
| publishDate | 2022-12-01 |
| publisher | Swiss Chemical Society |
| record_format | Article |
| series | CHIMIA |
| spelling | doaj.art-e14cc26d41c14406a59674cdda2a28682023-02-12T01:02:21ZdeuSwiss Chemical SocietyCHIMIA0009-42932673-24242022-12-01761210.2533/chimia.2022.1025Transporters for Bile Formation in Physiology and PathophysiologyBruno Stieger0Institute of Molecular Biology and Biophysics, ETH Zürich, 8093 Zürich The liver fulfills many vital functions for the body, among them bile formation and detoxification. Bile salts are organic anions, are the major constituents of bile and are at high concentrations cytotoxic. Detoxification exposes the liver to many harmful compounds. This function is therefore potentially damaging to the liver. Impaired bile formation may lead to hepatic accumulation of bile salts and subsequently to liver disease. Diagnosis of liver diseases involves the measurement of so-called liver function parameters. This overview aims to characterize and summarize the role of organic anion transporters in bile formation at the protein level under normal physiologic conditions and in liver function tests used for diagnosing liver diseases in pathophysiologic situations. https://chimia.ch/chimia/article/view/6107Function testLiverPathophysiologyPhysiologyTransporter |
| spellingShingle | Bruno Stieger Transporters for Bile Formation in Physiology and Pathophysiology CHIMIA Function test Liver Pathophysiology Physiology Transporter |
| title | Transporters for Bile Formation in Physiology and Pathophysiology |
| title_full | Transporters for Bile Formation in Physiology and Pathophysiology |
| title_fullStr | Transporters for Bile Formation in Physiology and Pathophysiology |
| title_full_unstemmed | Transporters for Bile Formation in Physiology and Pathophysiology |
| title_short | Transporters for Bile Formation in Physiology and Pathophysiology |
| title_sort | transporters for bile formation in physiology and pathophysiology |
| topic | Function test Liver Pathophysiology Physiology Transporter |
| url | https://chimia.ch/chimia/article/view/6107 |
| work_keys_str_mv | AT brunostieger transportersforbileformationinphysiologyandpathophysiology |