TERT-Promoter Mutational Status in Glioblastoma – Is There an Association With Amino Acid Uptake on Dynamic 18F-FET PET?
ObjectiveThe mutation of the ‘telomerase reverse transcriptase gene promoter’ (TERTp) has been identified as an important factor for individual prognostication and tumorigenesis and will be implemented in upcoming glioma classifications. Uptake characteristics on dynamic 18F-FET PET have been shown...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-04-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.645316/full |
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| author | Marcus Unterrainer Marcus Unterrainer Marcus Unterrainer Viktoria Ruf Katharina von Rohr Bogdana Suchorska Bogdana Suchorska Lena Maria Mittlmeier Leonie Beyer Matthias Brendel Vera Wenter Wolfgang G. Kunz Peter Bartenstein Peter Bartenstein Jochen Herms Maximilian Niyazi Maximilian Niyazi Jörg C. Tonn Jörg C. Tonn Nathalie Lisa Albert Nathalie Lisa Albert |
| author_facet | Marcus Unterrainer Marcus Unterrainer Marcus Unterrainer Viktoria Ruf Katharina von Rohr Bogdana Suchorska Bogdana Suchorska Lena Maria Mittlmeier Leonie Beyer Matthias Brendel Vera Wenter Wolfgang G. Kunz Peter Bartenstein Peter Bartenstein Jochen Herms Maximilian Niyazi Maximilian Niyazi Jörg C. Tonn Jörg C. Tonn Nathalie Lisa Albert Nathalie Lisa Albert |
| author_sort | Marcus Unterrainer |
| collection | DOAJ |
| description | ObjectiveThe mutation of the ‘telomerase reverse transcriptase gene promoter’ (TERTp) has been identified as an important factor for individual prognostication and tumorigenesis and will be implemented in upcoming glioma classifications. Uptake characteristics on dynamic 18F-FET PET have been shown to serve as additional imaging biomarker for prognosis. However, data on the correlation of TERTp-mutational status and amino acid uptake on dynamic 18F-FET PET are missing. Therefore, we aimed to analyze whether static and dynamic 18F-FET PET parameters are associated with the TERTp-mutational status in de-novo IDH-wildtype glioblastoma and whether a TERTp-mutation can be predicted by dynamic 18F-FET PET.MethodsPatients with de-novo IDH-wildtype glioblastoma, WHO grade IV, available TERTp-mutational status and dynamic 18F-FET PET scan prior to any therapy were included. Here, established clinical parameters maximal and mean tumor-to-background-ratios (TBRmax/TBRmean), the biological-tumor-volume (BTV) and minimal-time-to-peak (TTPmin) on dynamic PET were analyzed and correlated with the TERTp-mutational status.ResultsOne hundred IDH-wildtype glioblastoma patients were evaluated; 85/100 of the analyzed tumors showed a TERTp-mutation (C228T or C250T), 15/100 were classified as TERTp-wildtype. None of the static PET parameters was associated with the TERTp-mutational status (median TBRmax 3.41 vs. 3.32 (p=0.362), TBRmean 2.09 vs. 2.02 (p=0.349) and BTV 26.1 vs. 22.4 ml (p=0.377)). Also, the dynamic PET parameter TTPmin did not differ in both groups (12.5 vs. 12.5 min, p=0.411). Within the TERTp-mutant subgroups (i.e., C228T (n=23) & C250T (n=62)), the median TBRmax (3.33 vs. 3.69, p=0.095), TBRmean (2.08 vs. 2.09, p=0.352), BTV (25.4 vs. 30.0 ml, p=0.130) and TTPmin (12.5 vs. 12.5 min, p=0.190) were comparable, too.ConclusionUptake characteristics on dynamic 18F-FET PET are not associated with the TERTp-mutational status in glioblastoma However, as both, dynamic 18F-FET PET parameters as well as the TERTp-mutation status are well-known prognostic biomarkers, future studies should investigate the complementary and independent prognostic value of both factors in order to further stratify patients into risk groups. |
| first_indexed | 2024-12-20T08:53:41Z |
| format | Article |
| id | doaj.art-e14ce199347c4824be1992ab5489c475 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-20T08:53:41Z |
| publishDate | 2021-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-e14ce199347c4824be1992ab5489c4752022-12-21T19:46:05ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-04-011110.3389/fonc.2021.645316645316TERT-Promoter Mutational Status in Glioblastoma – Is There an Association With Amino Acid Uptake on Dynamic 18F-FET PET?Marcus Unterrainer0Marcus Unterrainer1Marcus Unterrainer2Viktoria Ruf3Katharina von Rohr4Bogdana Suchorska5Bogdana Suchorska6Lena Maria Mittlmeier7Leonie Beyer8Matthias Brendel9Vera Wenter10Wolfgang G. Kunz11Peter Bartenstein12Peter Bartenstein13Jochen Herms14Maximilian Niyazi15Maximilian Niyazi16Jörg C. Tonn17Jörg C. Tonn18Nathalie Lisa Albert19Nathalie Lisa Albert20Department of Radiology, University Hospital, LMU Munich, Munich, GermanyDepartment of Nuclear Medicine, University Hospital, LMU Munich, Munich, GermanyGerman Cancer Consortium (DKTK), Partner Site Munich and German Cancer Research Center (DKFZ), Heidelberg, GermanyDepartment of Neuropathology and Prion Research, LMU Munich, Munich, GermanyDepartment of Nuclear Medicine, University Hospital, LMU Munich, Munich, GermanyGerman Cancer Consortium (DKTK), Partner Site Munich and German Cancer Research Center (DKFZ), Heidelberg, GermanyDepartment of Neurosurgery, University Hospital, LMU Munich, Munich, GermanyDepartment of Nuclear Medicine, University Hospital, LMU Munich, Munich, GermanyDepartment of Nuclear Medicine, University Hospital, LMU Munich, Munich, GermanyDepartment of Nuclear Medicine, University Hospital, LMU Munich, Munich, GermanyDepartment of Nuclear Medicine, University Hospital, LMU Munich, Munich, GermanyDepartment of Radiology, University Hospital, LMU Munich, Munich, GermanyDepartment of Nuclear Medicine, University Hospital, LMU Munich, Munich, GermanyGerman Cancer Consortium (DKTK), Partner Site Munich and German Cancer Research Center (DKFZ), Heidelberg, GermanyDepartment of Neuropathology and Prion Research, LMU Munich, Munich, GermanyGerman Cancer Consortium (DKTK), Partner Site Munich and German Cancer Research Center (DKFZ), Heidelberg, GermanyDepartment of Radiation Oncology, University Hospital, LMU Munich, Munich, GermanyGerman Cancer Consortium (DKTK), Partner Site Munich and German Cancer Research Center (DKFZ), Heidelberg, GermanyDepartment of Neurosurgery, University Hospital, LMU Munich, Munich, GermanyDepartment of Nuclear Medicine, University Hospital, LMU Munich, Munich, GermanyGerman Cancer Consortium (DKTK), Partner Site Munich and German Cancer Research Center (DKFZ), Heidelberg, GermanyObjectiveThe mutation of the ‘telomerase reverse transcriptase gene promoter’ (TERTp) has been identified as an important factor for individual prognostication and tumorigenesis and will be implemented in upcoming glioma classifications. Uptake characteristics on dynamic 18F-FET PET have been shown to serve as additional imaging biomarker for prognosis. However, data on the correlation of TERTp-mutational status and amino acid uptake on dynamic 18F-FET PET are missing. Therefore, we aimed to analyze whether static and dynamic 18F-FET PET parameters are associated with the TERTp-mutational status in de-novo IDH-wildtype glioblastoma and whether a TERTp-mutation can be predicted by dynamic 18F-FET PET.MethodsPatients with de-novo IDH-wildtype glioblastoma, WHO grade IV, available TERTp-mutational status and dynamic 18F-FET PET scan prior to any therapy were included. Here, established clinical parameters maximal and mean tumor-to-background-ratios (TBRmax/TBRmean), the biological-tumor-volume (BTV) and minimal-time-to-peak (TTPmin) on dynamic PET were analyzed and correlated with the TERTp-mutational status.ResultsOne hundred IDH-wildtype glioblastoma patients were evaluated; 85/100 of the analyzed tumors showed a TERTp-mutation (C228T or C250T), 15/100 were classified as TERTp-wildtype. None of the static PET parameters was associated with the TERTp-mutational status (median TBRmax 3.41 vs. 3.32 (p=0.362), TBRmean 2.09 vs. 2.02 (p=0.349) and BTV 26.1 vs. 22.4 ml (p=0.377)). Also, the dynamic PET parameter TTPmin did not differ in both groups (12.5 vs. 12.5 min, p=0.411). Within the TERTp-mutant subgroups (i.e., C228T (n=23) & C250T (n=62)), the median TBRmax (3.33 vs. 3.69, p=0.095), TBRmean (2.08 vs. 2.09, p=0.352), BTV (25.4 vs. 30.0 ml, p=0.130) and TTPmin (12.5 vs. 12.5 min, p=0.190) were comparable, too.ConclusionUptake characteristics on dynamic 18F-FET PET are not associated with the TERTp-mutational status in glioblastoma However, as both, dynamic 18F-FET PET parameters as well as the TERTp-mutation status are well-known prognostic biomarkers, future studies should investigate the complementary and independent prognostic value of both factors in order to further stratify patients into risk groups.https://www.frontiersin.org/articles/10.3389/fonc.2021.645316/fullamino acid PETmolecular geneticsglioblastomaTERT (telomerase reverse transcriptase)FET PET |
| spellingShingle | Marcus Unterrainer Marcus Unterrainer Marcus Unterrainer Viktoria Ruf Katharina von Rohr Bogdana Suchorska Bogdana Suchorska Lena Maria Mittlmeier Leonie Beyer Matthias Brendel Vera Wenter Wolfgang G. Kunz Peter Bartenstein Peter Bartenstein Jochen Herms Maximilian Niyazi Maximilian Niyazi Jörg C. Tonn Jörg C. Tonn Nathalie Lisa Albert Nathalie Lisa Albert TERT-Promoter Mutational Status in Glioblastoma – Is There an Association With Amino Acid Uptake on Dynamic 18F-FET PET? Frontiers in Oncology amino acid PET molecular genetics glioblastoma TERT (telomerase reverse transcriptase) FET PET |
| title | TERT-Promoter Mutational Status in Glioblastoma – Is There an Association With Amino Acid Uptake on Dynamic 18F-FET PET? |
| title_full | TERT-Promoter Mutational Status in Glioblastoma – Is There an Association With Amino Acid Uptake on Dynamic 18F-FET PET? |
| title_fullStr | TERT-Promoter Mutational Status in Glioblastoma – Is There an Association With Amino Acid Uptake on Dynamic 18F-FET PET? |
| title_full_unstemmed | TERT-Promoter Mutational Status in Glioblastoma – Is There an Association With Amino Acid Uptake on Dynamic 18F-FET PET? |
| title_short | TERT-Promoter Mutational Status in Glioblastoma – Is There an Association With Amino Acid Uptake on Dynamic 18F-FET PET? |
| title_sort | tert promoter mutational status in glioblastoma is there an association with amino acid uptake on dynamic 18f fet pet |
| topic | amino acid PET molecular genetics glioblastoma TERT (telomerase reverse transcriptase) FET PET |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.645316/full |
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