Changes in megakaryopoiesis over ontogeny and their implications in health and disease
A growing body of research has made it increasingly clear that there are substantial biological differences between fetal/neonatal and adult megakaryopoiesis. Over the last decade, studies revealed a developmentally unique uncoupling of proliferation, polyploidization, and cytoplasmic maturation in...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-08-01
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| Series: | Platelets |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09537104.2020.1742879 |
| _version_ | 1827816883252887552 |
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| author | Patricia Davenport Zhi-Jian Liu Martha Sola-Visner |
| author_facet | Patricia Davenport Zhi-Jian Liu Martha Sola-Visner |
| author_sort | Patricia Davenport |
| collection | DOAJ |
| description | A growing body of research has made it increasingly clear that there are substantial biological differences between fetal/neonatal and adult megakaryopoiesis. Over the last decade, studies revealed a developmentally unique uncoupling of proliferation, polyploidization, and cytoplasmic maturation in neonatal MKs that results in the production of large numbers of small, low ploidy, but mature MKs during this period of development, and identified substantial molecular differences between fetal/neonatal and adult MKs. This review will summarize our current knowledge on the developmental differences between fetal/neonatal and adult MKs, and recent advances in our understanding of the underlying molecular mechanisms, including newly described developmentally regulated pathways and miRNAs. We will also discuss the implications of these findings on the ways MKs interact with the environment, the response of neonates to thrombocytopenia, the pathogenesis of Down syndrome-transient myeloproliferative disorder (TMD), and the developmental stage specific-manifestations of congenital amegakaryocytic thrombocytopenia. |
| first_indexed | 2024-03-12T00:26:40Z |
| format | Article |
| id | doaj.art-e14cfd60cf5c423d8ca649aca53cc48c |
| institution | Directory Open Access Journal |
| issn | 0953-7104 1369-1635 |
| language | English |
| last_indexed | 2024-03-12T00:26:40Z |
| publishDate | 2020-08-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Platelets |
| spelling | doaj.art-e14cfd60cf5c423d8ca649aca53cc48c2023-09-15T10:38:07ZengTaylor & Francis GroupPlatelets0953-71041369-16352020-08-0131669269910.1080/09537104.2020.17428791742879Changes in megakaryopoiesis over ontogeny and their implications in health and diseasePatricia Davenport0Zhi-Jian Liu1Martha Sola-Visner2Boston Children’s Hospital and Harvard Medical SchoolBoston Children’s Hospital and Harvard Medical SchoolBoston Children’s Hospital and Harvard Medical SchoolA growing body of research has made it increasingly clear that there are substantial biological differences between fetal/neonatal and adult megakaryopoiesis. Over the last decade, studies revealed a developmentally unique uncoupling of proliferation, polyploidization, and cytoplasmic maturation in neonatal MKs that results in the production of large numbers of small, low ploidy, but mature MKs during this period of development, and identified substantial molecular differences between fetal/neonatal and adult MKs. This review will summarize our current knowledge on the developmental differences between fetal/neonatal and adult MKs, and recent advances in our understanding of the underlying molecular mechanisms, including newly described developmentally regulated pathways and miRNAs. We will also discuss the implications of these findings on the ways MKs interact with the environment, the response of neonates to thrombocytopenia, the pathogenesis of Down syndrome-transient myeloproliferative disorder (TMD), and the developmental stage specific-manifestations of congenital amegakaryocytic thrombocytopenia.http://dx.doi.org/10.1080/09537104.2020.1742879fetusmegakaryocyteneonatethrombopoietin |
| spellingShingle | Patricia Davenport Zhi-Jian Liu Martha Sola-Visner Changes in megakaryopoiesis over ontogeny and their implications in health and disease Platelets fetus megakaryocyte neonate thrombopoietin |
| title | Changes in megakaryopoiesis over ontogeny and their implications in health and disease |
| title_full | Changes in megakaryopoiesis over ontogeny and their implications in health and disease |
| title_fullStr | Changes in megakaryopoiesis over ontogeny and their implications in health and disease |
| title_full_unstemmed | Changes in megakaryopoiesis over ontogeny and their implications in health and disease |
| title_short | Changes in megakaryopoiesis over ontogeny and their implications in health and disease |
| title_sort | changes in megakaryopoiesis over ontogeny and their implications in health and disease |
| topic | fetus megakaryocyte neonate thrombopoietin |
| url | http://dx.doi.org/10.1080/09537104.2020.1742879 |
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