The relationship between processed meat, red meat, and risk of types of cancer: A Mendelian randomization study
BackgroundObservational studies have suggested processed and red meat may increase the risk of cancer. However, the causal effects and direction between them were still unclear. We conducted two-sample Mendelian randomization (MR) analysis to evaluate the causal effect of processed meat and red meat...
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.942155/full |
| _version_ | 1797995337478045696 |
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| author | Kaiwen Wu Lei Liu Tao Shu Aoshuang Li Demeng Xia Xiaobin Sun |
| author_facet | Kaiwen Wu Lei Liu Tao Shu Aoshuang Li Demeng Xia Xiaobin Sun |
| author_sort | Kaiwen Wu |
| collection | DOAJ |
| description | BackgroundObservational studies have suggested processed and red meat may increase the risk of cancer. However, the causal effects and direction between them were still unclear. We conducted two-sample Mendelian randomization (MR) analysis to evaluate the causal effect of processed meat and red meat on the risk of nine common types of cancer, namely, lung, ovarian, endometrial, breast, kidney, gastric, prostate, skin, and oropharyngeal cancer.MethodsGenome-wide association studies (GWAS) for processed meat and red meat (pork, beef, and mutton) were obtained from the UK Biobank. GWAS of types of cancer in this study were extracted from the genetic consortia and the FinnGen consortium. The inverse variance weighted (IVW) was carried out as the main method for two-sample MR analysis. Sensitivity analyses were used to assess the robustness of the results.ResultsGenetically predicted processed meat intake was causally associated with increased risk of lung cancer (OR [odds ratio] = 1.923, 95% CI = 1.084–3.409, P = 0.025). There is no convincing evidence for the associations between genetically determined processed meat, red meat, and the risk of other cancers we studied.ConclusionOur results suggested that intake of processed meat may increase the risk of lung cancer. These findings provided no evidence to support that consumption of processed and red meat has a large effect on the risk of other cancers we studied. Further research is needed to clarify the results. |
| first_indexed | 2024-04-11T10:00:02Z |
| format | Article |
| id | doaj.art-e14d21f974644a3d8ece7a1940c19f3e |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-11T10:00:02Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-e14d21f974644a3d8ece7a1940c19f3e2022-12-22T04:30:27ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-09-01910.3389/fnut.2022.942155942155The relationship between processed meat, red meat, and risk of types of cancer: A Mendelian randomization studyKaiwen Wu0Lei Liu1Tao Shu2Aoshuang Li3Demeng Xia4Xiaobin Sun5School of Medicine, Southwest Jiaotong University, Department of Gastroenterology, The Third People's Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, Chengdu, ChinaMedical Research Center, Third People's Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University, Chengdu, ChinaSchool of Medicine, Southwest Jiaotong University, Department of Gastroenterology, The Third People's Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, Chengdu, ChinaSchool of Medicine, Southwest Jiaotong University, Department of Gastroenterology, The Third People's Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, Chengdu, ChinaLuodian Clinical Drug Research Center, Shanghai Baoshan Luodian Hospital, Shanghai University, Shanghai, ChinaSchool of Medicine, Southwest Jiaotong University, Department of Gastroenterology, The Third People's Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, Chengdu, ChinaBackgroundObservational studies have suggested processed and red meat may increase the risk of cancer. However, the causal effects and direction between them were still unclear. We conducted two-sample Mendelian randomization (MR) analysis to evaluate the causal effect of processed meat and red meat on the risk of nine common types of cancer, namely, lung, ovarian, endometrial, breast, kidney, gastric, prostate, skin, and oropharyngeal cancer.MethodsGenome-wide association studies (GWAS) for processed meat and red meat (pork, beef, and mutton) were obtained from the UK Biobank. GWAS of types of cancer in this study were extracted from the genetic consortia and the FinnGen consortium. The inverse variance weighted (IVW) was carried out as the main method for two-sample MR analysis. Sensitivity analyses were used to assess the robustness of the results.ResultsGenetically predicted processed meat intake was causally associated with increased risk of lung cancer (OR [odds ratio] = 1.923, 95% CI = 1.084–3.409, P = 0.025). There is no convincing evidence for the associations between genetically determined processed meat, red meat, and the risk of other cancers we studied.ConclusionOur results suggested that intake of processed meat may increase the risk of lung cancer. These findings provided no evidence to support that consumption of processed and red meat has a large effect on the risk of other cancers we studied. Further research is needed to clarify the results.https://www.frontiersin.org/articles/10.3389/fnut.2022.942155/fullprocessed meatred meatcancerMendelian randomizationgenome-wide association studies |
| spellingShingle | Kaiwen Wu Lei Liu Tao Shu Aoshuang Li Demeng Xia Xiaobin Sun The relationship between processed meat, red meat, and risk of types of cancer: A Mendelian randomization study Frontiers in Nutrition processed meat red meat cancer Mendelian randomization genome-wide association studies |
| title | The relationship between processed meat, red meat, and risk of types of cancer: A Mendelian randomization study |
| title_full | The relationship between processed meat, red meat, and risk of types of cancer: A Mendelian randomization study |
| title_fullStr | The relationship between processed meat, red meat, and risk of types of cancer: A Mendelian randomization study |
| title_full_unstemmed | The relationship between processed meat, red meat, and risk of types of cancer: A Mendelian randomization study |
| title_short | The relationship between processed meat, red meat, and risk of types of cancer: A Mendelian randomization study |
| title_sort | relationship between processed meat red meat and risk of types of cancer a mendelian randomization study |
| topic | processed meat red meat cancer Mendelian randomization genome-wide association studies |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.942155/full |
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