Development of a Treatment Protocol for Cobra (<i>Naja naja</i>) Bite Envenoming in Dogs
There is limited information on clinical profiles, treatment, and management aspects of Indian cobra (<i>Naja naja</i>) bite envenoming in dogs in Sri Lanka. Dogs with cobra bites presented to the Veterinary Teaching Hospital (VTH), University of Peradeniya, were prospectively studied ov...
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| Format: | Article |
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MDPI AG
2020-11-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/12/11/694 |
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| author | Ranjith Adhikari Lalith Suriyagoda Amal Premarathna Niranjala De Silva Ashoka Dangolla Chandima Mallawa Indira Silva Indika Gawarammana |
| author_facet | Ranjith Adhikari Lalith Suriyagoda Amal Premarathna Niranjala De Silva Ashoka Dangolla Chandima Mallawa Indira Silva Indika Gawarammana |
| author_sort | Ranjith Adhikari |
| collection | DOAJ |
| description | There is limited information on clinical profiles, treatment, and management aspects of Indian cobra (<i>Naja naja</i>) bite envenoming in dogs in Sri Lanka. Dogs with cobra bites presented to the Veterinary Teaching Hospital (VTH), University of Peradeniya, were prospectively studied over a period of 72 months; local and systemic clinical manifestations and hematological abnormalities were recorded. We studied 116 cobra bite envenomings in dogs. A grading system was established using a combination of anatomical site of fang marks, as well as local and systemic clinical manifestations. Accordingly, treatment strategies were established using Indian polyvalent antivenom (AVS). Pain and swelling at the bite site were major clinical signs observed, while neurotoxic manifestations (mydriasis, wheezing, and crackles) were detected in most dogs. Leukocytosis was observed in 78% of them. Statistical analysis revealed that the grading scores obtained were compatible to initiate AVS administration according to the severity. The minimum number required was 2 AVS vials (range 2–12). Almost 20% of the dogs developed wheezing, crackles, hypersalivation, restlessness, and dyspnea as adverse reactions to AVS treatment. Necrotic wounds on bitten anatomical sites developed in 19% of the dogs and 2.5% developed acute kidney injuries as a consequence of envenoming crisis. Despite treatment, 3% of dogs died. No dry bites were recorded. |
| first_indexed | 2024-03-10T15:09:29Z |
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| id | doaj.art-e14ec301dbaa48f3bf2711b1d1d33352 |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-03-10T15:09:29Z |
| publishDate | 2020-11-01 |
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| record_format | Article |
| series | Toxins |
| spelling | doaj.art-e14ec301dbaa48f3bf2711b1d1d333522023-11-20T19:31:27ZengMDPI AGToxins2072-66512020-11-01121169410.3390/toxins12110694Development of a Treatment Protocol for Cobra (<i>Naja naja</i>) Bite Envenoming in DogsRanjith Adhikari0Lalith Suriyagoda1Amal Premarathna2Niranjala De Silva3Ashoka Dangolla4Chandima Mallawa5Indira Silva6Indika Gawarammana7Department of Veterinary Clinical Sciences, Faculty of Veterinary Medicine and Animal Science, University of Peradeniya, Peradeniya 20400, Sri LankaDepartment of Crop Science, Faculty of Agriculture, University of Peradeniya, Peradeniya 20400, Sri LankaDepartment of Veterinary Pathobiology, Faculty of Veterinary Medicine and Animal Science, University of Peradeniya, Peradeniya 20400, Sri LankaDepartment of Veterinary Clinical Sciences, Faculty of Veterinary Medicine and Animal Science, University of Peradeniya, Peradeniya 20400, Sri LankaDepartment of Veterinary Clinical Sciences, Faculty of Veterinary Medicine and Animal Science, University of Peradeniya, Peradeniya 20400, Sri LankaDepartment of Veterinary Clinical Sciences, Faculty of Veterinary Medicine and Animal Science, University of Peradeniya, Peradeniya 20400, Sri LankaDepartment of Veterinary Clinical Sciences, Faculty of Veterinary Medicine and Animal Science, University of Peradeniya, Peradeniya 20400, Sri LankaDepartment of Medicine, Faculty of Medicine, University of Peradeniya, Peradeniya 20400, Sri LankaThere is limited information on clinical profiles, treatment, and management aspects of Indian cobra (<i>Naja naja</i>) bite envenoming in dogs in Sri Lanka. Dogs with cobra bites presented to the Veterinary Teaching Hospital (VTH), University of Peradeniya, were prospectively studied over a period of 72 months; local and systemic clinical manifestations and hematological abnormalities were recorded. We studied 116 cobra bite envenomings in dogs. A grading system was established using a combination of anatomical site of fang marks, as well as local and systemic clinical manifestations. Accordingly, treatment strategies were established using Indian polyvalent antivenom (AVS). Pain and swelling at the bite site were major clinical signs observed, while neurotoxic manifestations (mydriasis, wheezing, and crackles) were detected in most dogs. Leukocytosis was observed in 78% of them. Statistical analysis revealed that the grading scores obtained were compatible to initiate AVS administration according to the severity. The minimum number required was 2 AVS vials (range 2–12). Almost 20% of the dogs developed wheezing, crackles, hypersalivation, restlessness, and dyspnea as adverse reactions to AVS treatment. Necrotic wounds on bitten anatomical sites developed in 19% of the dogs and 2.5% developed acute kidney injuries as a consequence of envenoming crisis. Despite treatment, 3% of dogs died. No dry bites were recorded.https://www.mdpi.com/2072-6651/12/11/694cobra bite<i>Naja naja</i>dogsantivenom serumclinical manifestations |
| spellingShingle | Ranjith Adhikari Lalith Suriyagoda Amal Premarathna Niranjala De Silva Ashoka Dangolla Chandima Mallawa Indira Silva Indika Gawarammana Development of a Treatment Protocol for Cobra (<i>Naja naja</i>) Bite Envenoming in Dogs Toxins cobra bite <i>Naja naja</i> dogs antivenom serum clinical manifestations |
| title | Development of a Treatment Protocol for Cobra (<i>Naja naja</i>) Bite Envenoming in Dogs |
| title_full | Development of a Treatment Protocol for Cobra (<i>Naja naja</i>) Bite Envenoming in Dogs |
| title_fullStr | Development of a Treatment Protocol for Cobra (<i>Naja naja</i>) Bite Envenoming in Dogs |
| title_full_unstemmed | Development of a Treatment Protocol for Cobra (<i>Naja naja</i>) Bite Envenoming in Dogs |
| title_short | Development of a Treatment Protocol for Cobra (<i>Naja naja</i>) Bite Envenoming in Dogs |
| title_sort | development of a treatment protocol for cobra i naja naja i bite envenoming in dogs |
| topic | cobra bite <i>Naja naja</i> dogs antivenom serum clinical manifestations |
| url | https://www.mdpi.com/2072-6651/12/11/694 |
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