Efficacy and Safety of Tranexamic Acid in Melasma: A Meta-analysis and Systematic Review
Tranexamic acid is a novel treatment option for melasma; however, there is no consensus on its use. This systematic review searched major databases for relevant publications to March 2016. Eleven studies with 667 participants were included. Pooled data from tranexamic acid-only observational studies...
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| Format: | Article |
| Language: | English |
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Medical Journals Sweden
2017-04-01
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| Series: | Acta Dermato-Venereologica |
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https://www.medicaljournals.se/acta/content/html/10.2340/00015555-2668
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| _version_ | 1818322013486317568 |
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| author | Hyun Jung Kim Seok Hoon Moon Sang Hyun Cho Jeong Deuk Lee Hei Sung Kim |
| author_facet | Hyun Jung Kim Seok Hoon Moon Sang Hyun Cho Jeong Deuk Lee Hei Sung Kim |
| author_sort | Hyun Jung Kim |
| collection | DOAJ |
| description | Tranexamic acid is a novel treatment option for melasma; however, there is no consensus on its use. This systematic review searched major databases for relevant publications to March 2016. Eleven studies with 667 participants were included. Pooled data from tranexamic acid-only observational studies with pre- and post-treatment Melasma Area and Severity Index (MASI) showed a decrease of 1.60 in MASI (95% confidence interval (CI), 1.20–2.00; p < 0.001) after treatment with tranexamic acid. The addition of tranexamic acid to routine treatment modalities resulted in a further decrease in MASI of 0.94 (95% CI 0.10–1.79; p = 0.03). Side-effects were minor, with a few cases reporting hypomenorrhoea, mild abdominal discomfort, and transient skin irritation. These results support the efficacy and safety of tranexamic acid, either alone or as an adjuvant to routine treatment modalities for melasma. |
| first_indexed | 2024-12-13T10:50:03Z |
| format | Article |
| id | doaj.art-e14ec71b5a494cf6ab319dbe7bf2f63b |
| institution | Directory Open Access Journal |
| issn | 0001-5555 1651-2057 |
| language | English |
| last_indexed | 2024-12-13T10:50:03Z |
| publishDate | 2017-04-01 |
| publisher | Medical Journals Sweden |
| record_format | Article |
| series | Acta Dermato-Venereologica |
| spelling | doaj.art-e14ec71b5a494cf6ab319dbe7bf2f63b2022-12-21T23:49:53ZengMedical Journals SwedenActa Dermato-Venereologica0001-55551651-20572017-04-0197777678110.2340/00015555-26684948Efficacy and Safety of Tranexamic Acid in Melasma: A Meta-analysis and Systematic ReviewHyun Jung Kim0Seok Hoon MoonSang Hyun ChoJeong Deuk LeeHei Sung Kim Department of Preventive Medicine, Korea University College of Medicine, Seoul, Korea. Tranexamic acid is a novel treatment option for melasma; however, there is no consensus on its use. This systematic review searched major databases for relevant publications to March 2016. Eleven studies with 667 participants were included. Pooled data from tranexamic acid-only observational studies with pre- and post-treatment Melasma Area and Severity Index (MASI) showed a decrease of 1.60 in MASI (95% confidence interval (CI), 1.20–2.00; p < 0.001) after treatment with tranexamic acid. The addition of tranexamic acid to routine treatment modalities resulted in a further decrease in MASI of 0.94 (95% CI 0.10–1.79; p = 0.03). Side-effects were minor, with a few cases reporting hypomenorrhoea, mild abdominal discomfort, and transient skin irritation. These results support the efficacy and safety of tranexamic acid, either alone or as an adjuvant to routine treatment modalities for melasma. https://www.medicaljournals.se/acta/content/html/10.2340/00015555-2668 tranexamicacidmelasma:systematicreview meta-analysis |
| spellingShingle | Hyun Jung Kim Seok Hoon Moon Sang Hyun Cho Jeong Deuk Lee Hei Sung Kim Efficacy and Safety of Tranexamic Acid in Melasma: A Meta-analysis and Systematic Review Acta Dermato-Venereologica tranexamicacid melasma:systematicreview meta-analysis |
| title | Efficacy and Safety of Tranexamic Acid in Melasma: A Meta-analysis and Systematic Review |
| title_full | Efficacy and Safety of Tranexamic Acid in Melasma: A Meta-analysis and Systematic Review |
| title_fullStr | Efficacy and Safety of Tranexamic Acid in Melasma: A Meta-analysis and Systematic Review |
| title_full_unstemmed | Efficacy and Safety of Tranexamic Acid in Melasma: A Meta-analysis and Systematic Review |
| title_short | Efficacy and Safety of Tranexamic Acid in Melasma: A Meta-analysis and Systematic Review |
| title_sort | efficacy and safety of tranexamic acid in melasma a meta analysis and systematic review |
| topic | tranexamicacid melasma:systematicreview meta-analysis |
| url |
https://www.medicaljournals.se/acta/content/html/10.2340/00015555-2668
|
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