A Novel Blood‐Based Colorectal Cancer Diagnostic Technology Using Electrical Detection of Colon Cancer Secreted Protein‐2
Abstract Colorectal cancer (CRC) is the second‐leading cause of cancer‐related mortality worldwide, which may be effectively reduced by early screening. Colon cancer secreted protein‐2 (CCSP‐2) is a promising blood marker for CRC. An electric‐field effect colorectal sensor (E‐FECS), an ion‐sensitive...
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-06-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.201802115 |
| _version_ | 1818059807562661888 |
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| author | Minhong Jeun Hyo Jeong Lee Sungwook Park Eun‐ju Do Jaewon Choi You‐Na Sung Seung‐Mo Hong Sang‐Yeob Kim Dong‐Hee Kim Ja Young Kang Hye‐Nam Son Jinmyoung Joo Eun Mi Song Sung Wook Hwang Sang Hyoung Park Dong‐Hoon Yang Byong Duk Ye Jeong‐Sik Byeon Jaewon Choe Suk‐Kyun Yang Helen Moinova Sanford D. Markowitz Kwan Hyi Lee Seung‐Jae Myung |
| author_facet | Minhong Jeun Hyo Jeong Lee Sungwook Park Eun‐ju Do Jaewon Choi You‐Na Sung Seung‐Mo Hong Sang‐Yeob Kim Dong‐Hee Kim Ja Young Kang Hye‐Nam Son Jinmyoung Joo Eun Mi Song Sung Wook Hwang Sang Hyoung Park Dong‐Hoon Yang Byong Duk Ye Jeong‐Sik Byeon Jaewon Choe Suk‐Kyun Yang Helen Moinova Sanford D. Markowitz Kwan Hyi Lee Seung‐Jae Myung |
| author_sort | Minhong Jeun |
| collection | DOAJ |
| description | Abstract Colorectal cancer (CRC) is the second‐leading cause of cancer‐related mortality worldwide, which may be effectively reduced by early screening. Colon cancer secreted protein‐2 (CCSP‐2) is a promising blood marker for CRC. An electric‐field effect colorectal sensor (E‐FECS), an ion‐sensitive field‐effect transistor under dual gate operation with nanostructure is developed, to quantify CCSP‐2 directly from patient blood samples. The sensing performance of the E‐FECS is verified in 7 controls and 7 CRC samples, and it is clinically validated on 30 controls, 30 advanced adenomas, and 81 CRC cases. The concentration of CCSP‐2 is significantly higher in plasma samples from CRC and advanced adenoma compared with controls (both P < 0.001). Sensitivity and specificity for CRC versus controls are 44.4% and 86.7%, respectively (AUC of 0.67), and 43.3% and 86.7%, respectively, for advanced adenomas (AUC of 0.67). CCSP‐2 detects a greater number of CRC cases than carcinoembryonic antigen does (45.6% vs 24.1%), and the combination of the two markers detects an even greater number of cases (53.2%). The E‐FECS system successfully detects CCSP‐2 in a wide range of samples including early stage cancers and advanced adenoma. CCSP‐2 has potential for use as a blood‐based biomarker for CRC. |
| first_indexed | 2024-12-10T13:22:24Z |
| format | Article |
| id | doaj.art-e150f65f03bf4074ab12ca4c8a9e5ebf |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-12-10T13:22:24Z |
| publishDate | 2019-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-e150f65f03bf4074ab12ca4c8a9e5ebf2022-12-22T01:47:17ZengWileyAdvanced Science2198-38442019-06-01611n/an/a10.1002/advs.201802115A Novel Blood‐Based Colorectal Cancer Diagnostic Technology Using Electrical Detection of Colon Cancer Secreted Protein‐2Minhong Jeun0Hyo Jeong Lee1Sungwook Park2Eun‐ju Do3Jaewon Choi4You‐Na Sung5Seung‐Mo Hong6Sang‐Yeob Kim7Dong‐Hee Kim8Ja Young Kang9Hye‐Nam Son10Jinmyoung Joo11Eun Mi Song12Sung Wook Hwang13Sang Hyoung Park14Dong‐Hoon Yang15Byong Duk Ye16Jeong‐Sik Byeon17Jaewon Choe18Suk‐Kyun Yang19Helen Moinova20Sanford D. Markowitz21Kwan Hyi Lee22Seung‐Jae Myung23Center for Biomaterials Biomedical Research Institute Korea Institute of Science and Technology (KIST) 5 Hwarangno 14‐gil Seongbuk‐gu Seoul 02792 Republic of KoreaHealth Screening & Promotion Center Asan Medical Center 88 Olympic‐ro 43‐gil Songpa‐gu Seoul 05505 Republic of KoreaCenter for Biomaterials Biomedical Research Institute Korea Institute of Science and Technology (KIST) 5 Hwarangno 14‐gil Seongbuk‐gu Seoul 02792 Republic of KoreaAsan Institute for Life Sciences Asan Medical Center 88 Olympic‐ro 43‐gil Songpa‐gu Seoul 05505 Republic of KoreaCenter for Biomaterials Biomedical Research Institute Korea Institute of Science and Technology (KIST) 5 Hwarangno 14‐gil Seongbuk‐gu Seoul 02792 Republic of KoreaDepartment of Pathology Asan Medical Center University of Ulsan College of Medicine 88 Olympic‐ro 43‐gil Songpa‐gu Seoul 05505 Republic of KoreaDepartment of Pathology Asan Medical Center University of Ulsan College of Medicine 88 Olympic‐ro 43‐gil Songpa‐gu Seoul 05505 Republic of KoreaAsan Institute for Life Sciences Asan Medical Center 88 Olympic‐ro 43‐gil Songpa‐gu Seoul 05505 Republic of KoreaAsan Institute for Life Sciences Asan Medical Center 88 Olympic‐ro 43‐gil Songpa‐gu Seoul 05505 Republic of KoreaAsan Institute for Life Sciences Asan Medical Center 88 Olympic‐ro 43‐gil Songpa‐gu Seoul 05505 Republic of KoreaAsan Institute for Life Sciences Asan Medical Center 88 Olympic‐ro 43‐gil Songpa‐gu Seoul 05505 Republic of KoreaAsan Institute for Life Sciences Asan Medical Center 88 Olympic‐ro 43‐gil Songpa‐gu Seoul 05505 Republic of KoreaDepartment of Gastroenterology Asan Medical Center University of Ulsan College of Medicine 88 Olympic‐ro 43‐gil Songpa‐gu Seoul 05505 Republic of KoreaDepartment of Gastroenterology Asan Medical Center University of Ulsan College of Medicine 88 Olympic‐ro 43‐gil Songpa‐gu Seoul 05505 Republic of KoreaDepartment of Gastroenterology Asan Medical Center University of Ulsan College of Medicine 88 Olympic‐ro 43‐gil Songpa‐gu Seoul 05505 Republic of KoreaDepartment of Gastroenterology Asan Medical Center University of Ulsan College of Medicine 88 Olympic‐ro 43‐gil Songpa‐gu Seoul 05505 Republic of KoreaDepartment of Gastroenterology Asan Medical Center University of Ulsan College of Medicine 88 Olympic‐ro 43‐gil Songpa‐gu Seoul 05505 Republic of KoreaDepartment of Gastroenterology Asan Medical Center University of Ulsan College of Medicine 88 Olympic‐ro 43‐gil Songpa‐gu Seoul 05505 Republic of KoreaHealth Screening & Promotion Center Asan Medical Center 88 Olympic‐ro 43‐gil Songpa‐gu Seoul 05505 Republic of KoreaDepartment of Gastroenterology Asan Medical Center University of Ulsan College of Medicine 88 Olympic‐ro 43‐gil Songpa‐gu Seoul 05505 Republic of KoreaDepartment of Medicine and Case Comprehensive Cancer Center Case Western Reserve University 10900 Euclid Ave Cleveland OH USADepartment of Medicine and Case Comprehensive Cancer Center Case Western Reserve University 10900 Euclid Ave Cleveland OH USACenter for Biomaterials Biomedical Research Institute Korea Institute of Science and Technology (KIST) 5 Hwarangno 14‐gil Seongbuk‐gu Seoul 02792 Republic of KoreaAsan Institute for Life Sciences Asan Medical Center 88 Olympic‐ro 43‐gil Songpa‐gu Seoul 05505 Republic of KoreaAbstract Colorectal cancer (CRC) is the second‐leading cause of cancer‐related mortality worldwide, which may be effectively reduced by early screening. Colon cancer secreted protein‐2 (CCSP‐2) is a promising blood marker for CRC. An electric‐field effect colorectal sensor (E‐FECS), an ion‐sensitive field‐effect transistor under dual gate operation with nanostructure is developed, to quantify CCSP‐2 directly from patient blood samples. The sensing performance of the E‐FECS is verified in 7 controls and 7 CRC samples, and it is clinically validated on 30 controls, 30 advanced adenomas, and 81 CRC cases. The concentration of CCSP‐2 is significantly higher in plasma samples from CRC and advanced adenoma compared with controls (both P < 0.001). Sensitivity and specificity for CRC versus controls are 44.4% and 86.7%, respectively (AUC of 0.67), and 43.3% and 86.7%, respectively, for advanced adenomas (AUC of 0.67). CCSP‐2 detects a greater number of CRC cases than carcinoembryonic antigen does (45.6% vs 24.1%), and the combination of the two markers detects an even greater number of cases (53.2%). The E‐FECS system successfully detects CCSP‐2 in a wide range of samples including early stage cancers and advanced adenoma. CCSP‐2 has potential for use as a blood‐based biomarker for CRC.https://doi.org/10.1002/advs.201802115colorectal adenomascolorectal cancercolorectal cancer screeningelectric‐field effect colorectal sensortumor markers |
| spellingShingle | Minhong Jeun Hyo Jeong Lee Sungwook Park Eun‐ju Do Jaewon Choi You‐Na Sung Seung‐Mo Hong Sang‐Yeob Kim Dong‐Hee Kim Ja Young Kang Hye‐Nam Son Jinmyoung Joo Eun Mi Song Sung Wook Hwang Sang Hyoung Park Dong‐Hoon Yang Byong Duk Ye Jeong‐Sik Byeon Jaewon Choe Suk‐Kyun Yang Helen Moinova Sanford D. Markowitz Kwan Hyi Lee Seung‐Jae Myung A Novel Blood‐Based Colorectal Cancer Diagnostic Technology Using Electrical Detection of Colon Cancer Secreted Protein‐2 Advanced Science colorectal adenomas colorectal cancer colorectal cancer screening electric‐field effect colorectal sensor tumor markers |
| title | A Novel Blood‐Based Colorectal Cancer Diagnostic Technology Using Electrical Detection of Colon Cancer Secreted Protein‐2 |
| title_full | A Novel Blood‐Based Colorectal Cancer Diagnostic Technology Using Electrical Detection of Colon Cancer Secreted Protein‐2 |
| title_fullStr | A Novel Blood‐Based Colorectal Cancer Diagnostic Technology Using Electrical Detection of Colon Cancer Secreted Protein‐2 |
| title_full_unstemmed | A Novel Blood‐Based Colorectal Cancer Diagnostic Technology Using Electrical Detection of Colon Cancer Secreted Protein‐2 |
| title_short | A Novel Blood‐Based Colorectal Cancer Diagnostic Technology Using Electrical Detection of Colon Cancer Secreted Protein‐2 |
| title_sort | novel blood based colorectal cancer diagnostic technology using electrical detection of colon cancer secreted protein 2 |
| topic | colorectal adenomas colorectal cancer colorectal cancer screening electric‐field effect colorectal sensor tumor markers |
| url | https://doi.org/10.1002/advs.201802115 |
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